論文

査読有り 国際誌
2022年1月

Metabolic profiling of charged metabolites in association with menopausal status in Japanese community-dwelling midlife women: Tsuruoka Metabolomic Cohort Study

Maturitas
  • Keiko Watanabe
  • ,
  • Miho Iida
  • ,
  • Sei Harada
  • ,
  • Suzuka Kato
  • ,
  • Kazuyo Kuwabara
  • ,
  • Ayako Kurihara
  • ,
  • Ayano Takeuchi
  • ,
  • Daisuke Sugiyama
  • ,
  • Tomonori Okamura
  • ,
  • Asako Suzuki
  • ,
  • Kaori Amano
  • ,
  • Akiyoshi Hirayama
  • ,
  • Masahiro Sugimoto
  • ,
  • Tomoyoshi Soga
  • ,
  • Masaru Tomita
  • ,
  • Yusuke Kobayashi
  • ,
  • Kouji Banno
  • ,
  • Daisuke Aoki
  • ,
  • Toru Takebayashi

155
開始ページ
54
終了ページ
62
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.maturitas.2021.10.004
出版者・発行元
Elsevier BV

BACKGROUND: Emerging evidence has shown that charged metabolites, such as amino acids, may play an important role in the pathogenesis of various metabolic disorders, many of which women in the postmenopausal period are at high risk of developing. This study examined the metabolic profile of middle-aged Japanese women to investigate alterations in charged metabolites induced by menopausal transition. METHODS: The participants were 1193 female residents aged 40-60 at the baseline survey of the Tsuruoka Metabolomics Cohort Study. We investigated the cross-sectional association of menopausal status with 94 metabolomic biomarkers assayed in fasting plasma samples via capillary electrophoresis time-of-flight mass spectrometry using linear regression analysis. RESULTS: Among the participants, 529 were premenopausal, 132 were in menopausal transition (MT), and 532 were postmenopausal. Significant differences were found in age, blood pressure, glucose and lipid levels, and smoking and drinking habits among the three groups. The concentrations of 5 metabolites in the MT group and 15 metabolites in the postmenopausal group were significantly higher than those in the premenopausal group after adjusting for confounding factors. When classified into pathways, these metabolites were related to the tricarboxylic cycle, urea cycle, and homocysteine metabolism, some of which are linked to arteriosclerosis. CONCLUSION: Multiple charged metabolites were associated with women's menopausal status, showing a gradual increase as women shifted from pre-, to peri-, to postmenopause. These findings might reflect the early changes behind the increased risk of dyslipidemia, diabetes, cardiovascular disease, and osteoporosis in later life.

リンク情報
DOI
https://doi.org/10.1016/j.maturitas.2021.10.004
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34876249
ID情報
  • DOI : 10.1016/j.maturitas.2021.10.004
  • ISSN : 0378-5122
  • PubMed ID : 34876249

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