MISC

2009年2月

The role of complement activation, detected by urinary C5b-9 and urinary factor H, in the excretion of urinary albumin in cisplatin nephropathy

CLINICAL NEPHROLOGY
  • Y. Fuke
  • ,
  • T. Fujita
  • ,
  • A. Satomura
  • ,
  • M. Endo
  • ,
  • K. Matsumoto

71
2
開始ページ
110
終了ページ
117
記述言語
英語
掲載種別
出版者・発行元
DUSTRI-VERLAG DR KARL FEISTLE

Aims: Cis-diaminedichloroplatium II (CDDP) is an antineoplastic agent with serious renal toxicity, although the cause is not fully understood. The aim of this study was to clarify the functional roles of complement activation in cisplatin-nephropathy by examining the urinary complement components, C5b-9 and factor H. Subjects: Five patients with advanced lung cancer were included in this study as they were due to receive CDDP or 1,1-cyclobutanedicarboxylatoplatinum II (CBDA). Methods: Urine samples were collected before and after the chemotherapy for 13 days for measurements of C5b-9 (U-C5b-9), factor H (U-fH), albumin (U-Alb), (beta(2)-microglobulin (U-beta(2)MG), and N-acetyl-beta-D-glucosamidase (NAG). Results: The mean level of U-Alb during the 5 - 8 day period after CDDP treatment was significantly higher than before treatment (p < 0.01). There was no significant correlation between U-Alb and NAG (r = -0.031, p = 0.994), or U-Alb and U-beta(2)MG (r=0.061, p =0.978) during the 5 - 8 day after CDDP treatment. U-Alb, U-C5b-9 and U-fH clearly increased on Days 4 - 10 after CDDP treatment. In our three patients treated with CDDP, mean estimated glomerular filtration rate (eGFR) was slightly decreased at 7 and 13 days after the treatment, compared to that of pretreatment, whereas there was no difference of eGFR between 7 and 13 days. Inpatients treated with CBDA, these parameters were clearly at lower levels compared to those patients treated with CDDP. Conclusion: This study demonstrates that cisplatin may activate the complement pathway in the glomerulus, with factor H regulating the activation, resulting in decreased urinary albumin excretion and renoprotection.

リンク情報
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000263907700002&DestApp=WOS_CPL
ID情報
  • ISSN : 0301-0430
  • Web of Science ID : WOS:000263907700002

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