論文

査読有り
2015年10月

MicroRNA-145 regulates osteoblastic differentiation by targeting the transcription factor Cbfb

FEBS LETTERS
  • Toru Fukuda
  • ,
  • Hiroki Ochi
  • ,
  • Satoko Sunamura
  • ,
  • Akina Haiden
  • ,
  • Waka Bando
  • ,
  • Hiroyuki Inose
  • ,
  • Atsushi Okawa
  • ,
  • Yoshinori Asou
  • ,
  • Shu Takeda

589
21
開始ページ
3302
終了ページ
3308
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.febslet.2015.09.024
出版者・発行元
ELSEVIER SCIENCE BV

Osteoblastic differentiation is regulated by various factors, including hormones and transcription factors. Runt-related transcription factor 2 (Runx2) is an essential player in osteoblastogenesis and transactivates its molecular target by creating a protein complex with its hetero-dimeric partner core binding factor beta (Cbfb). However, the molecular regulation of Cbfb expression remains unknown. Here, we identified miR-145 as a crucial regulator of Cbfb expression. The expression of miR-145 increased during osteoblastogenesis, indicating that miR-145 works as an inhibitor of osteoblastogenesis. Stable expression of miR-145 decreased endogenous Cbfb expression and inhibited osteoblastogenesis, in cooperation with miR-34c. Furthermore, miR-145 decreased bone regeneration in vivo. Our results indicate that miR-145 physiologically regulates osteoblast differentiation and bone formation via Cbfb expression by forming a regulatory microRNA network. (C) 2015 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.febslet.2015.09.024
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/26450370
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000364604900013&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.febslet.2015.09.024
  • ISSN : 0014-5793
  • eISSN : 1873-3468
  • PubMed ID : 26450370
  • Web of Science ID : WOS:000364604900013

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