論文

査読有り 国際誌
2020年1月

Correlation between eosinophil count, its genetic background and body mass index: The Nagahama Study.

Allergology international : official journal of the Japanese Society of Allergology
  • Hironobu Sunadome
  • Hisako Matsumoto
  • Yumi Izuhara
  • Tadao Nagasaki
  • Yoshihiro Kanemitsu
  • Yumi Ishiyama
  • Chie Morimoto
  • Tsuyoshi Oguma
  • Isao Ito
  • Kimihiko Murase
  • Shigeo Muro
  • Takahisa Kawaguchi
  • Yasuharu Tabara
  • Kazuo Chin
  • Fumihiko Matsuda
  • Toyohiro Hirai
  • 全て表示

69
1
開始ページ
46
終了ページ
52
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.alit.2019.05.012

BACKGROUND: Obesity affects the pathogenesis of various chronic diseases, including asthma. Research on correlations between obesity/BMI and eosinophilic inflammation in asthma has yielded contradictory results, which could be partly ascribed to the absence of epidemiological data on the correlations. We aimed to elucidate the correlations between blood eosinophil count, its genetic backgrounds, and BMI in the general population. METHODS: This community-based Nagahama study in Japan enrolled 9789 inhabitants. We conducted self-reporting questionnaires, lung function tests, and blood tests in the baseline and 5-year follow-up studies. A genome-wide association study (GWAS) was performed in 4650 subjects at the baseline and in 4206 of these at the follow-up to determine single-nucleotide polymorphisms for elevated blood eosinophil counts. We assessed the correlations between BMI and eosinophil counts using a multifaceted approach, including the cluster analysis. RESULTS: Eosinophil counts positively correlated with BMI, observed upon the interchange of an explanatory variable, except for subjects with the highest quartile of eosinophils (≥200/μL), in whom BMI negatively correlated with eosinophil counts. GWAS and human leukocyte antigen (HLA) imputation identified rs4713354 variant (MDC1 on chromosome 6p21) for elevated eosinophil counts, independent of BMI and IgE. Rs4713354 was accumulated in a cluster characterized by elevated eosinophil counts (mean, 498 ± 178/μL) but normal BMI. CONCLUSIONS: Epidemiologically, there may be a positive association between blood eosinophil counts and BMI in general, but there was a negative correlation in the population with high eosinophil counts. Factors other than BMI, particularly genetic backgrounds, may contribute to elevated eosinophil counts in such populations.

リンク情報
DOI
https://doi.org/10.1016/j.alit.2019.05.012
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/31272903
ID情報
  • DOI : 10.1016/j.alit.2019.05.012
  • PubMed ID : 31272903

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