2021年5月1日
Miniaturized LED light source with an excitation filter for fluorescent imaging
Japanese Journal of Applied Physics
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- 巻
- 60
- 号
- SB
- 開始ページ
- SBBG07
- 終了ページ
- SBBG07
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.35848/1347-4065/abe5bf
- 出版者・発行元
- IOP Publishing
In this study, we developed a miniaturized InGaN blue mu LED-based excitation source intended for an implantable lens-less brain imaging system. To enhance its implantability, the mu LED was thinned further through the laser lift-off process. A filtering component comprising a short-pass interference filter and a low-NA fiber optic plate (FOP), was loaded onto the mu LED. The addition of an interference filter reduced normal incident green-end band emissions from the mu LED by two orders of magnitude. The application of FOP enables the resolution of the angle-dependent problem of the interference filter. Further, a fluorescent imaging experiment was carried out on the proposed excitation source. The proposed device produced bright fluorescence images that are sufficient for implantable in vivo application. The thickness of the proposed excitation device was 180 mu m, making it suitable for implantable brain fluorescent imaging applications.
- リンク情報
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- DOI
- https://doi.org/10.35848/1347-4065/abe5bf
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000624518600001&DestApp=WOS_CPL
- 共同研究・競争的資金等の研究課題
- ミクロからマクロまでシームレスに細胞と会話する光技術の開発
- 共同研究・競争的資金等の研究課題
- レーザー剥離加工による低侵襲かつ高感度な刺入型脳機能イメージングデバイス
- URL
- https://iopscience.iop.org/article/10.35848/1347-4065/abe5bf
- URL
- https://iopscience.iop.org/article/10.35848/1347-4065/abe5bf/pdf
- ID情報
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- DOI : 10.35848/1347-4065/abe5bf
- ISSN : 0021-4922
- eISSN : 1347-4065
- Web of Science ID : WOS:000624518600001