Masaatsu Adachi

Profile Information

Affiliation: -

Degree: 工学博士(東京工業大学)

J-GLOBAL ID: 200901005651330203
researchmap Member ID: 6000010147

External link: http://www.agr.nagoya-u.ac.jp/~organic/

Research Interests

有機合成化学生物有機化学天然物有機化学

Research Areas

Life sciences / Pharmaceuticals - chemistry and drug development /

Research History

Apr, 2018 - Present

Lecturer, Graduate School of Bioagricultural Sciences, Nagoya University
May, 2017 - Mar, 2018

Lecturer, Graduate School of Bioagricultural Sciences Department of Applied Molecular Biosciences Division of Biofunctional Chemistry, Nagoya University
Apr, 2007 - Apr, 2017

Assistant Professor, Graduate School of Bioagricultural Sciences Department of Applied Molecular Biosciences, Nagoya University
Apr, 2007

Graduate School of Bioagricultural Sciences, Nagoya University
Apr, 2006 - Mar, 2007

Assistant, Graduate School of Bioagricultural Sciences Department of Applied Molecular Biosciences, Nagoya University
Apr, 2006 - Mar, 2007

Graduate School of Bioagricultural Sciences, Nagoya University
Oct, 2004 - Mar, 2006

米国Harvard大学博士研究員
Apr, 2004 - Sep, 2004

財団法人理工学振興会博士研究員
Lecturer, Nagoya University Graduate School of Bioagricultural Sciences

Awards

Papers

The odor of a nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, is detected by specific olfactory sensory neurons of the green spotted puffers but is processed in overlapping olfactory bulbar area with food odors

Takehisa Suzuki, Ryota Nakahigashi, Masaatsu Adachi, Toshio Nishikawa, Hideki Abe

bioRxiv, Aug 22, 2023
An almost nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an odorant for the grass puffer.

Yoshihisa Noguchi, Takehisa Suzuki, Keigo Matsutani, Ryo Sakakibara, Ryota Nakahigashi, Masaatsu Adachi, Toshio Nishikawa, Hideki Abe

Scientific reports, 12(1) 15087-15087, Sep 5, 2022 Peer-reviewed
Total Syntheses of the Proposed Biosynthetic Intermediates of Tetrodotoxin Tb-210B, Tb-226, Tb-242C, and Tb-258.

Masafumi Nishiumi, Tadachika Miyasaka, Masaatsu Adachi, Toshio Nishikawa

The Journal of organic chemistry, 87(14) 9023-9033, Jul 15, 2022
Domestic cat damage to plant leaves containing iridoids enhances chemical repellency to pests

Reiko Uenoyama, Tamako Miyazaki, Masaatsu Adachi, Toshio Nishikawa, Jane L. Hurst, Masao Miyazaki

iScience, 25(7), Jul 15, 2022
Domestic cat damage to plant leaves containing iridoids enhances chemical repellency to pests.

Reiko Uenoyama, Tamako Miyazaki, Masaatsu Adachi, Toshio Nishikawa, Jane L Hurst, Masao Miyazaki

iScience, 25(7) 104455-104455, Jul 15, 2022
Synthesis of the 8-Deoxy Analogue of 4,9-Anhydro-10-hemiketal-5-deoxy-tetrodotoxin, a Proposed Biosynthetic Precursor of Tetrodotoxin.

Tadachika Miyasaka, Masaatsu Adachi, Toshio Nishikawa

Organic letters, 23(23) 9232-9236, Dec 3, 2021 Peer-reviewed
JBIR-155, a Specific Class D β-Lactamase Inhibitor of Microbial Origin.

Takehiro Nishimura, Teppei Kawahara, Noritaka Kagaya, Yusuke Ogura, Hirosato Takikawa, Hikaru Suenaga, Masaatsu Adachi, Takatsugu Hirokawa, Takayuki Doi, Kazuo Shin-Ya

Organic letters, 23(11) 4415-4419, Jun 4, 2021 Peer-reviewed
First Detection of Tetrodotoxins in the Cotylean Flatworm Prosthiostomum trilineatum.

Rei Suo, Maho Kashitani, Hikaru Oyama, Masaatsu Adachi, Ryota Nakahigashi, Ryo Sakakibara, Toshio Nishikawa, Haruo Sugita, Shiro Itoi

Marine drugs, 19(1), Jan 18, 2021 Peer-reviewed
The characteristic response of domestic cats to plant iridoids allows them to gain chemical defense against mosquitoes.

Reiko Uenoyama, Tamako Miyazaki, Jane L Hurst, Robert J Beynon, Masaatsu Adachi, Takanobu Murooka, Ibuki Onoda, Yu Miyazawa, Rieko Katayama, Tetsuro Yamashita …

Science advances, 7(4), Jan, 2021 Peer-reviewed
Biosynthesis of Indole Diterpene Lolitrems: Radical-Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton.

Yulu Jiang, Taro Ozaki, Mei Harada, Tadachika Miyasaka, Hajime Sato, Kazunori Miyamoto, Junichiro Kanazawa, Chengwei Liu, Jun-Ichi Maruyama, Masaatsu Adachi …

Angewandte Chemie (International ed. in English), 59(41) 17996-18002, Oct 5, 2020 Peer-reviewed
Asymmetric Synthesis of the Aromatic Fragment of Sespendole.

Yoshiki Ono, Atsuo Nakazaki, kaori Ueki, Keiko Higuchi, Uraiwan Sriphana, Masaatsu Adachi, Toshio Nishikawa

J. Org. Chem., 84 9750-9757, Oct, 2019 Peer-reviewed
A Concise Stereocontrolled Synthesis of an α-Carbagalactose Segment of RCAI-56, a Candidate of Anticancer Agent.

Naoki Ushida, Nobukazu Nagai, Masaatsu Adachi, Toshio Nishikawa

Synlett, 977-981, Jun, 2019 Peer-reviewed
Total Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210, Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt.

Masaatsu Adachi, Tadachika Miyasaka, Yuta Kudo, keita Sugimoto, Mari Yotsu-Yamashita, Toshio Nishikawa

Org. Lett., 21(3) 780-784, May, 2019 Peer-reviewed
Facile Enzymatic Synthesis of Phosphatidylthreonine Using an Engineered Phospholipase D

Jasmina Damnjanović, Nozomi Matsunaga, Masaatsu Adachi, Hideo Nakano, Yugo Iwasaki

European Journal of Lipid Science and Technology, 120(6), Jun 1, 2018
Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na(v)1.1 to Na(v)1.7)

Tadaaki Tsukamoto, Yukie Chiba, Minoru Wakamori, Tomoshi Yamada, Shunsuke Tsunogae, Yuko Cho, Ryo Sakakibara, Takuya Imazu, Shouta Tokoro, Yoshiki Satake …

BRITISH JOURNAL OF PHARMACOLOGY, 174(21) 3881-3892, Nov, 2017
One-Step Transformation of Trichloroacetamide into Isonitrile

Masaatsu Adachi, Tadachika Miyasaka, Honoka Hashimoto, Toshio Nishikawa

ORGANIC LETTERS, 19(2) 380-383, Jan, 2017 Peer-reviewed
Direct Enzymatic Synthesis of 1-Phosphatidyl-β-D-glucose by Engineered Phospholipase D

Arisa Inoue, Masaatsu Adachi, Jasmina Damnjanović, Hideo Nakano, Yugo Iwasaki

ChemistrySelect, 1(13) 4121-4125, 2016 Peer-reviewed
Improved Syntheses of (+)-Iridomyrmecin and (-)-Isoiridomyrmecin, Major Components of Matatabilactone.

Masaatsu Adachi, Yu Miyazawa, Toshio Nishikawa

Natural Product Communications, 11 883-886, Jan, 2016 Peer-reviewed
Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin.

Nishikawa, T, Urabe, D, Adachi, M, Isobe, M

Synlett, 26 1930-1939, Jul 1, 2015 Peer-reviewedInvited
分子内C-グリコシル化反応を利用したPolygalolide Aの全合成

安立昌篤

有機合成化学協会誌, 73 607-615, May 1, 2015 Peer-reviewedInvited

Misc.

Synthetic studies on 4,9-anhydro-10-hemiketal-5-deoxytetrodotoxin

宮坂忠親, 安立昌篤, 西川俊夫

日本農芸化学会大会講演要旨集(Web), 2021, 2021
テトロドトキシン推定生合成中間体のテトロドトキシン含有生物への投与

杉本敬太, 工藤雄大, 宮坂忠親, 安立昌篤, 長由扶子, 此木敬一, 千葉親文, 西川俊夫, 山下まり

日本農芸化学会大会講演要旨集(Web), 2019, 2019
テトロドトキシンの推定生合成中間体の全合成と絶対立体配置の決定

宮坂忠親, 安立昌篤, 工藤雄大, 杉本敬太, 山下まり, 西川俊夫

日本農芸化学会大会講演要旨集(Web), 2019, 2019
多環テルペンインドールの新合成法

山口将司, 小野義貴, 樋口恵子, 杉野公美, 安立昌篤, 中崎敦夫, 西川俊夫

日本農芸化学会大会講演要旨集(Web), 2019, 2019
Facile Enzymatic Synthesis of Phosphatidylthreonine Using an Engineered Phospholipase D

Jasmina Damnjanović, Nozomi Matsunaga, Masaatsu Adachi, Hideo Nakano, Yugo Iwasaki

European Journal of Lipid Science and Technology, 120(6), Jun 1, 2018
テトロドトキシンの推定生合成中間体の合成研究

宮坂忠親, 安立昌篤, 杉本敬太, 山下まり, 西川俊夫

日本農芸化学会大会講演要旨集(Web), 2018, 2018
テトロドトキシンの推定生合成中間体の合成研究

宮坂忠親, 安立昌篤, 杉本敬太, 山下まり, 西川俊夫

有機合成シンポジウム講演予稿集, 113th, 2018
Differential binding of tetrodotoxin and its derivatives to voltage-sensitive sodium channel subtypes (Na(v)1.1 to Na(v)1.7)

Tadaaki Tsukamoto, Yukie Chiba, Minoru Wakamori, Tomoshi Yamada, Shunsuke Tsunogae, Yuko Cho, Ryo Sakakibara, Takuya Imazu, Shouta Tokoro, Yoshiki Satake …

BRITISH JOURNAL OF PHARMACOLOGY, 174(21) 3881-3892, Nov, 2017
Differential Binding of Tetrodotoxin and its Derivatives to Voltage-sensitive Sodium Channel Subtypes (Nav1.1 to Nav1.7)

Tsukamoto, T, Chiba, Y, Wakamori, M, Yamada, T, Tsunogae, S, Cho, Y, Sakakibara, R, Imazu, T, Tokoro, S, Satake, Y …

Br. J. Pharmacol., 174 3881-3892, Aug, 2017 Peer-reviewed
トリクロロアセトアミドからイソニトリルへの新規な一段階変換反応

宮坂忠親, 橋本穂果, 安立昌篤, 西川俊夫

日本農芸化学会大会講演要旨集(Web), 2017, 2017
One-Step Transformation of Trichloroacetamide into Isonitrile

Masaatsu Adachi, Tadachika Miyasaka, Honoka Hashimoto, Toshio Nishikawa

ORGANIC LETTERS, 19(2) 380-383, Jan, 2017 Peer-reviewed
トリクロロアセトアミドからイソニトリルへの新規な一段階変換反応

宮坂忠親, 橋本穂果, 安立昌篤, 西川俊夫

中部化学関係学協会支部連合秋季大会講演予稿集, 47th, 2016
Multifunctionality of the N-Trichloroacetyl Group Developed in the Synthesis of Tetrodotoxin, a Puffer Fish Toxin.

Nishikawa, T, Urabe, D, Adachi, M, Isobe, M

Synlett, 26 1930-1939, Jul 1, 2015 Peer-reviewedInvited
Total Synthesis of Polygalolide A by Intramolecular C-Glycosylation

Masaatsu Adachi

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 73(6) 607-615, Jun, 2015
分子内C-グリコシル化反応を利用したPolygalolide Aの全合成

安立昌篤

有機合成化学協会誌, 73 607-615, May 1, 2015 Peer-reviewedInvited
Asymmetric synthesis of 3-azide-4-fluoro-l-phenylalanine

Masaatsu Adachi, Mado Nakajima, Minoru Isobe

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 79(5) 707-709, May, 2015 Peer-reviewed
Stereocontrolled Synthesis of ABC Tricycle of Solanoeclepin A

Masaatsu Adachi, Mai Torii, Toshio Nishikawa

SYNLETT, 26(7) 965-969, Apr, 2015 Peer-reviewed
A New Deprotection Procedure of MTM Ether

Adachi, M, Hashimoto, H, Sakakibara, R, Imazu, T, Nishikawa, T

Synlett, 2498-2502, Dec 1, 2014 Peer-reviewed
Synthesis of 5,6,11-Trideoxytetrodotoxin

Masaatsu Adachi, Ryo Sakakibara, Yoshiki Satake, Minoru Isobe, Toshio Nishikawa

CHEMISTRY LETTERS, 43(11) 1719-1721, Nov, 2014 Peer-reviewed
インドールアルカロイドセスペンドールの合成研究

樋口恵子, 杉野公美, 中崎敦夫, 安立昌篤, 西川俊夫

日本農芸化学会大会講演要旨集(Web), 2014, 2014

Books and Other Publications

*C-Glycosylation, Chemical Glycosylation Reactions, In Glycoscience, 2nd edition

Toshio Nishikawa, Masaatsu Adachi, Minoru Isobe (Role: Joint author)

Springer Verlag, 2008

Professional Memberships

日本化学会、日本農芸化学会、日本糖質学会、有機合成化学協会

Research Projects

植物寄生性農害虫孵化促進活性を有する歪んだ架橋型多環性天然物の合成研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

安立昌篤
Collective synthesis of natural products and elucidation of its biological functions

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

NISHIKAWA Toshio
特異な生態機構を制御する寄主植物由来超微量多環性天然有機化合物の合成研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2018 - Mar, 2021

安立昌篤
ラジカル反応を機軸としたジャガイモシスト線虫孵化促進物質の合成研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2015 - Mar, 2018
Control of ion-channel functions by analogues of natural toxins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area), Japan Society for the Promotion of Science, Apr, 2011 - Mar, 2016

Nishikawa Toshio, Konoki Kei-ichi, Adachi Masaatsu
高度に歪んだ架橋型多環性骨格構築法の開発と植物寄生性線虫孵化促進化合物の合成研究

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2012 - Mar, 2015

安立昌篤
Synthetic study on bioactive natural product, causing hatching phenomenon toward potato Cyst nematodes, by construction of highly-substituted cyclobutane skeleton

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2010 - 2011

ADACHI Masaatsu
Synthetic Studies on biologically active natural products containing novel heterocyclic structures

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2008 - 2011

NISHIKAWA Toshio, ADACHI Masaatsu, NAKAZAKI Atsuo
分子内C-グリコシル化反応を用いるオキサビシクロ骨格の効率的構築法の開発

科学研究費助成事業, 19880013, Apr, 2007 - Mar, 2009

安立昌篤
The Innovative Synthesis of Bioactive Molecules based on the Molecular Mechanism of Natural Products Activity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Specially Promoted Research, Japan Society for the Promotion of Science, 2004 - 2008

ISOBE Minoru, ICHIKAWA Yoshiyasu, NISHIKAWA Toshio, KUSE Masaki, KAI Hidenori, ADACHI Masaatsu
グリカール分子変換反応による官能基化環状骨格の構築と生理活性天然物の合成研究

科学研究費助成事業, 若手研究(B)，課題番号：20780082, 2008

安立昌篤

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