Tomoko Takamiya - My portal - researchmap

Profile Information

Affiliation: Assistant Professor, School of Pharmacy Department of Pharmacy, Nihon University

Researcher number: 50513917
J-GLOBAL ID: 200901026921290907
researchmap Member ID: 6000011253

Research Interests

4

Research Areas

1

Life sciences / Molecular biology / Molecular Biology

Research History

2

Apr, 2008 - Present

Nihon University School of Pharmacy, Assistant professor
Apr, 2017

Nihon University School of Pharmacy, Assistant professor

Education

1

- 2008

Department of Biological Science and Technology, Graduate School, Division of Engineering Science, Science University of Tokyo

Awards

1

Nov, 2010

日本DNA多型学会優秀研究賞, ラン科Dendrobium属のrDNA-ITSデータベースを用いた生薬「石斛」の基原植物の同定

Papers

18

Structural and Computational Analyses of the Unique Interactions of Opicapone in the Binding Pocket of Catechol O-Methyltransferase: A Crystallographic Study and Fragment Molecular Orbital Analyses

Katsuki Takebe, Mamoru Suzuki, Takao Kuwada-Kusunose, Satoko Shirai, Kaori Fukuzawa, Tomoko Takamiya, Narikazu Uzawa, Hiroshi Iijima

Journal of Chemical Information and Modeling, Jul 12, 2023 Peer-reviewed
Dendrobium popaense (Orchidaceae)—A New Species from Myanmar.

Tomohisa Yukawa, Tomoko Takamiya, Mu Mu Aung, Khin Myo Htwe, Nobuyuki Tanaka

Bull. Natl. Mus. Nat. Sci., Ser. B, 48(3) 71-77, Aug 22, 2022 Peer-reviewed
Crystal Structure of Catechol O-Methyltransferase Complexed with Nitecapone.

Iijima H, Takebe K, Suzuki M, Kobayashi H, Takamiya T, Saito H, Niwa N, Kuwada-Kusunose T.

Chem. Pharm. Bull., 68(5) 447-451, Mar 1, 2020 Peer-reviewed
Identification of two phenanthrene derivatives from australasian allied species in genus dendrobium

Tomoko Takamiya, Saki Kitamura, Shunichiro Suzuki, Nao Shioda, Yoshifumi Matsuo, Kento Murase, Yuka Kaiho, Yurika Tsurumaki, Yukiko Fujiwara, Mayumi Sone …

Chemical and Pharmaceutical Bulletin, 66(6) 642-650, 2018 Peer-reviewed
A Sequence-tagged Site Marker for Identifying the Japanese Mat Rush (Juncus effusus) Cultivar 'Hinomidori'

Tomotsugu Noguchi, Saeko Hosobuchi, Tomoko Takamiya, Kazuhiko Iimure, Akira Saito, Yuhko Ohtake, Hideji Yamashita, Yasufumi Murakami, Hisato Okuizumi

JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY, 51(1) 45-49, Jan, 2017 Peer-reviewed
Structure-activity relationship of the inhibitory effects of flavonoids on nitric oxide production in RAW264.7 cells

Wen-Jun Jiang, Akihiro Daikonya, Mitsuyoshi Ohkawara, Takashi Nemoto, Ryusuke Noritake, Tomoko Takamiya, Susumu Kitanaka, Hiroshi Iijima

BIOORGANIC & MEDICINAL CHEMISTRY, 25(2) 779-788, Jan, 2017 Peer-reviewed
Stereospecific inhibition of nitric oxide production in macrophage cells by flavanonols: Synthesis and the structure-activity relationship. Part 2

Wen-Jun Jiang, Susumu Kitanaka, Tomoko Takamiya, Hiroshi Iijima

Bioorganic and Medicinal Chemistry, 25(16) 4277-4284, 2017 Peer-reviewed
Saikokaryukotsuboreito during pregnancy protects rat neonates from maternal cannibalism and death in a neurolathyrism experimental model.

Kuniko Kusama-Eguchi, Kimino Kawaguchi, Syuji Yakubo, Susum Kitanaka, Keiichi Matsuzaki, Tomoko Takamiya, Noboru Fukuda, Takashi Masuko, Dai Hirose, Mitsuko Makino …

Traditional & Kampo Medicine, DOI: 10.1002/tkm2.1047, Apr 8, 2016 Peer-reviewed
Stereospecific inhibition of nitric oxide production in macrophage cells by flavanonols: Synthesis and the structure–activity relationship.

Wen-Jun Jiang, Kan’ichiro Ishiuchi, Megumi Furukawa, Tomoko Takamiya, Susumu Kitanaka, Hiroshi Iijima

Bioorganic & Medicinal Chemistry, 23 6922-6929, Oct 28, 2015 Peer-reviewed
Molecular phylogenetics and character evolution of morphologically diverse groups, Dendrobium section Dendrobium and allies

Tomoko Takamiya, Pheravut Wongsawad, Apirada Sathapattayanon, Natsuko Tajima, Shunichiro Suzuki, Saki Kitamura, Nao Shioda, Takashi Handa, Susumu Kitanaka, Hiroshi Iijima …

AOB PLANTS, 6(plu045), 2014 Peer-reviewed
Effects of the herbal medicine composition "Saiko-ka-ryukotsu-borei-To" on the function of endothelial progenitor cells in hypertensive rats

Hiroshi Iijima, Akihiro Daikonya, Satoshi Takamatsu, Ai Kanno, Kayoko Magariyama, Kazuki Yoshikawa, Tomoko Takamiya, Yukiko Ueda, Shuji Yakubo, Taro Matsumoto …

PHYTOMEDICINE, 20(3-4) 196-201, Feb, 2013 Peer-reviewed
Identification of Dendrobium Species Used for Herbal Medicines Based on Ribosomal DNA Internal Transcribed Spacer Sequence

Tomoko Takamiya, Pheravut Wongsawad, Natsuko Tajima, Nao Shoda, Jun Feng Lu, Chi Luan Wen, Jin Bin Wu, Takashi Handa, Hiroshi Iijima, Susumu Kitanaka …

BIOLOGICAL & PHARMACEUTICAL BULLETIN, 34(5) 779-782, May, 2011 Peer-reviewed
Quantification of Norepinephrine and Its Metabolites in the Plasma of Renal Failure Models

Hiroshi Iijima, Yuji Okada, Makoto Tsunoda, Tomoko Takamiya, Kazuhiro Imai

NEPHRON PHYSIOLOGY, 116(2) P9-P16, 2010 Peer-reviewed
The Application of Restriction Landmark Genome Scanning Method for Surveillance of Non-Mendelian Inheritance in F-1 Hybrids

Tomoko Takamiya, Saeko Hosobuchi, Tomotsugu Noguchi, Andrew H. Paterson, Hiroshi Iijima, Yasufumi Murakami, Hisato Okuizumi

COMPARATIVE AND FUNCTIONAL GENOMICS, DOI: 10.1155/2009/245927, 2009 Peer-reviewed
Inheritance and alteration of genome methylation in F1 hybrid rice

Tomoko Takamiya, Saeko Hosobuchi, Tomotsugu Noguchi, Kenji Asai, Eiji Nakamura, Yoshiki Habu, Andrew H. Paterson, Hiroshi Iijima, Yasufumi Murakami, Hisato Okuizumi

ELECTROPHORESIS, 29(19) 4088-4095, Oct, 2008 Peer-reviewed
Application of RLGS Method for Detection of Alteration in Tissue Cultured Plants

Tomoko Takamiya, Yuhko Ohtake, Saeko Hosobuchi, Tomotsugu Noguchi, Makoto Kawase, Yasufumi Murakami, Hisato Okuizumi

JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY, 42(3) 151-155, Jul, 2008 Peer-reviewed
Restriction landmark genome scanning method using isoschizomers (MspI/HpaII) for DNA methylation analysis

Tomoko Takamiya, Saeko Hosobuchi, Kenji Asai, Eiji Nakamura, Keisuke Tomioka, Makoto Kawase, Tetsuji Kakutani, Andrew H. Paterson, Yasufumi Murakami, Hisato Okuizumi

ELECTROPHORESIS, 27(14) 2846-2856, Jul, 2006 Peer-reviewed
Development of a new cultivar-discrimination method based on DNA polymorphism in a vegetatively propagated crop

H Okamoto, T Takamiya, A Saito, E Domon, K Iimure, K Tomioka, M Kawase, Y Ohtake, Murakami, V, H Okuizumi

JARQ-JAPAN AGRICULTURAL RESEARCH QUARTERLY, 40(1) 65-69, Jan, 2006 Peer-reviewed

Misc.

4

Search for potential medicinal resources in Dendrobium by analyses of genetic and chemical similarities.

Takamiya T., Kitamura S., Suzuki S., Shioda N., Furukawa M., Makino M., Matsuzaki K., Kitanaka S., Yukawa T., Iijima H

Proceedings. The 11th Asia Pacific Orchid Conference in Okinawa & Okinawa International Orchid Show, 256-262, Jul 31, 2013 InvitedLead author
柴胡加竜骨牡蛎湯の血管内皮前駆細胞保護作用(2)

飯島洋, 永田悠, 廣松由衣, 高橋弘輝, 宮本知明, 吉田有佳里, 石村創祐, 大塚秀人, 多和有生, 高松智 …

日本薬学会年会要旨集(CD-ROM), 133rd(2) ROMBUNNO.28PMA-183-169, Mar, 2013
柴胡加竜骨牡蠣湯の抗酸化ストレス作用

大塚秀人, 多和有生, 宮本知明, 吉田有佳里, 石村創祐, 高橋弘樹, 永田悠, 廣松由衣, 高松智, 高宮知子 …

日本生薬学会年会講演要旨集, 59th 104-104, Aug 31, 2012
柴胡加竜骨牡蛎湯の血管内皮前駆細胞保護作用

飯島洋, 大根谷章浩, 菅野愛, 曲山佳代子, 芳川和輝, 高松智, 高宮知子, 矢久保修嗣, 福田昇, 北中進

日本薬学会年会要旨集, 131st(2) 225-225, Mar 5, 2011

Books and Other Publications

16

Research on potential medicinal resources in Dendrobium . −Bioactivities of extracts from several species of Dendrobium −

曽根麻友美, 藤原有紀子, 町田智美, 松本亮平, 菊地秦平, 清水玲子, 吉野圭一, 北中進, 遊川知久, 飯島洋, 高宮知子 (Original Author(s): 曽根麻友美, 藤原有紀子, 町田智美, 松本亮平, 菊地秦平, 清水玲子, 吉野圭一, 北中進, 遊川知久, 飯島洋, 高宮知子)

日本植物園協会, Nov 1, 2015
ラン科セッコク属（Dendrobium）の分子系統情報とHPLCプロファイル情報を統合した潜在薬用資源の探索I

高宮知子, 鈴木俊一郎, 北村早希, 北中進, 飯島洋, 遊川知久 (Original Author(s): 高宮知子, 鈴木俊一郎, 北村早希, 北中進, 飯島洋, 遊川知久)

May 30, 2013
DNA Methylation

Tomoko Takamiya, Saeko Hosobuchi, Kaliyamoorthy Seetharam, Yasufumi Murakami, Hisato Okuizumi (Role: Joint author, Chapter4, Inheritance of DNA methylation in plant genome.) (Original Author(s): Tomoko Takamiya, Saeko Hosobuchi, Kaliyamoorthy Seetharam, Yasufumi Murakami, Hisato Okuizumi)

InTech, Mar 16, 2012 (ISBN: 9789535103202)
Methods in Molecular Biology, Epigenetics protocols, Restriction Landmark Genome Scanning.

Hisato Okuizumi, Tomoko Takamiya, Yasushi Okazaki, Yoshihide Hayashizaki (Role: Joint author, Chapter8, 101-112) (Original Author(s): Hisato Okuizumi, Tomoko Takamiya, Yasushi Okazaki, Yoshihide Hayashizaki)

Springer Science+Business Media, Sep, 2011 (ISBN: 9781617793158)
ラン科Dendrobium属のrDNA-ITSデータベースを用いた生薬「石斛」の基原植物の同定

高宮知子, Pheravut Wongsawad, 田島奈津子, 塩田奈央, 半田高, 飯島洋, 北中進, 遊川知久 (Original Author(s): 高宮知子, Pheravut Wongsawad, 田島奈津子, 塩田奈央, 半田高, 飯島洋, 北中進, 遊川知久)

May 30, 2011
コンニャクの育成品種識別マーカーの開発.

野口友嗣, 細渕朗子, 飯塚弘明, 加藤晃, 高宮知子, 山下秀次, 村上康文, 奥泉久人 (Original Author(s): 野口友嗣, 細渕朗子, 飯塚弘明, 加藤晃, 高宮知子, 山下秀次, 村上康文, 奥泉久人)

May 30, 2011
イネの正逆交配F1を用いたDNAメチル化の非メンデル遺伝の検出

高宮知子, 細渕朗子, 野口友嗣, 飯島洋, 村上康文, 奥泉久人 (Original Author(s): 高宮知子, 細渕朗子, 野口友嗣, 飯島洋, 村上康文, 奥泉久人)

May 30, 2010
植物におけるDNAメチレーションのRLGS解析.

奥泉久人, 野中絵梨, 野口友嗣, 佐藤友則, 高宮知子, 飯島洋, 村上康文 (Original Author(s): 奥泉久人, 野中絵梨, 野口友嗣, 佐藤友則, 高宮知子, 飯島洋, 村上康文)

May 30, 2009
RLGS法を用いたコンニャク品種識別共優性マーカーの開発.

野口友嗣, 細渕朗子, 高宮知子, 飯塚弘明, 村上康文, 山下秀次, 奥泉久人 (Original Author(s): 野口友嗣,細渕朗子,高宮知子,飯塚弘明,村上康文,山下秀次,奥泉久人)

May 30, 2008
RLGS法を用いたソルガムDNA多型の検出.

奥泉久人, 山中慎介, Koffi Kombate, 野口友嗣, 細渕朗子, 高宮知子, Tariq Shehzad, 奥野員敏 (Original Author(s): 奥泉久人, 山中慎介, Koffi Kombate, 野口友嗣,細渕朗子,高宮知子,Tariq Shehzad, 奥野員敏)

May 30, 2008
コンニャク品種識別マーカーの開発.

野口友嗣, 細渕朗子, 高宮知子, 飯塚弘明, 山下秀次, 村上康文, 奥泉久人 (Original Author(s): 野口友嗣, 細渕朗子, 高宮知子,飯塚弘明, 山下秀次, 村上康文, 奥泉久人)

May 30, 2007
RLGS法によるシロイヌナズナのDNA多型の検出

高宮知子, 岡田有裕, 細渕朗子, 岡本裕行, 村上康文, 奥泉久人 (Original Author(s): 高宮知子, 岡田有裕, 細渕朗子, 岡本裕行, 村上康文, 奥泉久人)

May 30, 2006
コンニャクにおける品種識別RLGSマーカーの開発

飯塚弘明, 加藤晃, 内田秀司, 細渕朗子, 高宮知子, 村上康文, 山下秀次, 奥泉久人 (Original Author(s): 飯塚弘明, 加藤晃, 内田秀司, 細渕朗子, 高宮知子, 村上康文, 山下秀次, 奥泉久人)

May 30, 2006
植物クローンのRLGS多型検出技術の開発

大竹裕子, 高宮知子, 奥泉久人 (Original Author(s): 大竹裕子, 高宮知子, 奥泉久人)

May 30, 2005
ニワトリにおける多型検出法の開発

山川直美, 奥泉久人, 高宮知子, 盧尚建, 鏡味裕 (Original Author(s): 山川直美, 奥泉久人, 高宮知子, 盧尚建, 鏡味裕)

May 30, 2005
イグサ品種のDNA多型マーカーの開発

奥泉久人, 高宮知子, 大竹裕子, 山下秀次 (Original Author(s): 奥泉久人, 高宮知子, 大竹裕子, 山下秀次)

May 30, 2005

Major Presentations

61

Phylogenetic Information-Assisted Metabolomics of Dendrobium.

Tomoko Takamiya, Hiroshi Iijima, Tomohisa Yukawa

The 23rd World Orchid Conference, Apr 23, 2021

More

Professional Memberships

3

Apr, 2011 - Present

The Japanese Society of Pharmacognosy
Apr, 2010 - Present

The Pharmaceutical Society of Japan
Apr, 2006 - Present

Japanese Society for DNA Polymorphism

Research Projects

4

菌根菌を用いたラン科セッコク属植物の有用物質産生システムの構築

科学研究費助成事業, 基盤(C), 日本学術振興会, Apr, 2021 - Mar, 2024
カテコール-O-メチル転移酵素の賦活化物質の研究：COMT不全解消を目指して

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2015 - Mar, 2017

飯島洋
ラン科セッコク属植物の包括的情報構築と潜在的薬用資源の探索

科学研究費助成事業, Grant-in-Aid for Young scientists (B), 日本学術振興会, Apr, 2015 - Mar, 2017
化合物によるカテコールーＯーメチル転移酵素の生成物阻害解除機構の解明

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2012 - Mar, 2014

Industrial Property Rights

1

特願2018-186801 カテコールーOーメチルトランスフェラーゼ賦活化剤及び医薬組成物

飯島洋, 高宮知子