J-GLOBAL         Last updated: Sep 10, 2019 at 12:45
Oita University
Faculty of Medicine
Job title

Research Areas


Published Papers

Journal of Pharmacological Sciences      Jul 2019   [Refereed]
Mari Sasaki, Takeshi Terabayashi, Takeshi Terabayashi, Stefanie M. Weiss, Stefanie M. Weiss, Ingvar Ferby
Cell Reports   24(5) 1278-1289   Jul 2018   [Refereed]
© 2018 The Author(s) MIG6 is an important tumor suppressor that binds to and negatively regulates epidermal growth factor receptor (EGFR). Here, we report an EGFR-independent function for MIG6 as an integral component of the cell cycle machinery. ...
Takeshi Terabayashi, Katsuhiro Hanada, Kou Motani, Hidetaka Kosako, Mami Yamaoka, Toshihide Kimura, Toshimasa Ishizaki
Genes to Cells   23(6) 466-479   Jun 2018   [Refereed]
© 2018 Molecular Biology Society of Japan and John Wiley & Sons Australia, Ltd During tumor invasion, cancer cells change their morphology and mode of migration based on communication with the surrounding environment. Numerous studies have indic...
Takeshi Terabayashi, Katsuhiro Hanada
Cell Biology and Toxicology   1-14   Apr 2018   [Refereed]
© 2018 Springer Science+Business Media B.V., part of Springer Nature Maintenance of genome integrity is essential for all organisms because genome information regulates cell proliferation, growth arrest, and vital metabolic processes in cells, tis...
Mami Yamaoka, Tomomi Ando, Takeshi Terabayashi, Mitsuhiro Okamoto, Masahiro Takei, Tomoki Nishioka, Kozo Kaibuchi, Kozo Kaibuchi, Kohichi Matsunaga, Ray Ishizaki, Tetsuro Izumi, Ichiro Niki, Toshimasa Ishizaki, Toshihide Kimura
Journal of Cell Science   129(3) 637-649   Jan 2016   [Refereed]
In secretory cells, endocytosis is coupled to exocytosis to enable proper secretion. Although endocytosis is crucial to maintain cellular homeostasis before and after secretion, knowledge about secretagogue-induced endocytosis in secretory cells i...
Yasuka L. Yamaguchi, Satomi S. Tanaka, Maho Kumagai, Yuka Fujimoto, Takeshi Terabayashi, Yasuhisa Matsui, Ryuichi Nishinakamura
Stem Cells   33(1) 289-300   Jan 2015   [Refereed]
© 2014 AlphaMed Press. The Spalt-like 4 (Sall4) zinc finger protein is a critical transcription factor for pluripotency in embryonic stem cells (ESCs). It is also involved in the formation of a variety of organs, in mice, and humans. We report the...
Okamoto Mitsuhiro, Yamaoka Mami, Ando Tomomi, Takei Masahiro, Taniguchi Shigeki, Terabayashi Takeshi, Niki Ichiro, Ishizaki Toshimasa, Kimura Toshihide
NITRIC OXIDE-BIOLOGY AND CHEMISTRY   39 S31-S32   May 2014   [Refereed]
Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes
Okamoto Mitsuhiro, Yamaoka Mami, Ando Tomomi, Terabayashi Takeshi, Takei Masahiro, Niki Ichiro, Ishizaki Toshimasa, Kimura Toshihide
M. Villacorte, M. Villacorte, M. Villacorte, K. Suzuki, K. Suzuki, K. Suzuki, A. Hirasawa, Y. Ohkawa, M. Suyama, T. Maruyama, D. Aoki, Y. Ogino, S. Miyagawa, T. Terabayashi, Y. Tomooka, N. Nakagata, G. Yamada, G. Yamada, G. Yamada
Oncogene   32(29) 3477-3482   Jul 2013   [Refereed]
The Wnt/β-catenin signaling is essential for various organogenesis and is often implicated during tumorigenesis. Dysregulated β-catenin signaling is associated with the formation of endometrial adenocarcinomas (EACs), which is considered as the co...
Satomi S. Tanaka, Akihiro Nakane, Akihiro Nakane, Yasuka L. Yamaguchi, Takeshi Terabayashi, Takeshi Terabayashi, Takaya Abe, Kazuki Nakao, Makoto Asashima, Kirsten A. Steiner, Patrick P.L. Tam, Patrick P.L. Tam, Ryuichi Nishinakamura
PLoS ONE   8(3)    Mar 2013   [Refereed]
Dullard/Ctdnep1 is a member of the serine/threonine phosphatase family of the C-terminal domain of eukaryotic RNA polymerase II. Embryos lacking Dullard activity fail to form primordial germ cells (PGCs). In the mouse, the formation of PGCs is inf...
Takeshi Terabayashi, Takeshi Terabayashi, Masaji Sakaguchi, Masaji Sakaguchi, Kaori Shinmyozu, Toshio Ohshima, Ai Johjima, Ai Johjima, Teru Ogura, Teru Ogura, Hiroaki Miki, Ryuichi Nishinakamura, Ryuichi Nishinakamura
PLoS ONE   7(6)    Jun 2012   [Refereed]
Kif26b, a member of the kinesin superfamily proteins (KIFs), is essential for kidney development. Kif26b expression is restricted to the metanephric mesenchyme, and its transcription is regulated by a zinc finger transcriptional regulator Sall1. H...
Yosuke Funato, Takeshi Terabayashi, Takeshi Terabayashi, Reiko Sakamoto, Daisuke Okuzaki, Hirotake Ichise, Hiroshi Nojima, Nobuaki Yoshida, Hiroaki Miki
Current Biology   20(21) 1945-1952   Nov 2010   [Refereed]
Overexpression of Dishevelled (Dvl), an essential component of the Wnt signaling pathway, is frequently associated with tumors [1, 2], and thus the Dvl protein level must be tightly controlled to sustain Wnt signaling without causing tumors. Kelch...
Tatsuya Hayashi, Yosuke Funato, Takeshi Terabayashi, Takeshi Terabayashi, Akifumi Morinaka, Reiko Sakamoto, Hirotake Ichise, Hiroyuki Fukuda, Nobuaki Yoshida, Hiroaki Miki
Journal of Biological Chemistry   285(24) 18586-18593   Jun 2010   [Refereed]
We previously characterized nucleoredoxin (NRX) as a negative regulator of the Wnt signaling pathway through Dishevelled (Dvl). We perform a comprehensive search for other NRX-interacting proteins and identify Flightless-I (Fli-I) as a novel NRX-b...
Yukako Uchiyama, Yukako Uchiyama, Masaji Sakaguchi, Masaji Sakaguchi, Masaji Sakaguchi, Takeshi Terabayashi, Takeshi Terabayashi, Toshiaki Inenaga, Shuji Inoue, Shuji Inoue, Chiyoko Kobayashi, Naoko Oshima, Hiroshi Kiyonari, Naomi Nakagata, Yuya Sato, Kiyotoshi Sekiguchi, Hiroaki Miki, Eiichi Araki, Sayoko Fujimura, Satomi S. Tanaka, Ryuichi Nishinakamura, Ryuichi Nishinakamura
Proceedings of the National Academy of Sciences of the United States of America   107(20) 9240-9245   May 2010   [Refereed]
The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the m...
Yuta Yoshimura, Takeshi Terabayashi, Takeshi Terabayashi, Hiroaki Miki
Molecular and Cellular Biology   30(9) 2206-2219   May 2010   [Refereed]
Here we report that Par1b/MARK2 regulates axon formation via phosphorylation of a kinesin superfamily protein GAKIN/KIF13B. Accumulating evidence indicated the importance of the evolutionarily conserved kinase Par1b in the regulation of cell polar...
Takeshi Terabayashi, Yosuke Funato, Mitsunori Fukuda, Hiroaki Miki
Journal of Biological Chemistry   284(39) 26716-26724   Sep 2009   [Refereed]
Receptor internalization is recognized as an important mechanism for controlling numerous cell surface receptors. This event contributes not only to regulate signal transduction but also to adjust the amount of cell surface receptors. Frizzleds (F...
Takeshi Terabayashi, Yosuke Funato, Hiroaki Miki
Biochemical and Biophysical Research Communications   375(4) 660-665   Oct 2008   [Refereed]
Par1b is an evolutionarily conserved kinase that plays crucial roles in cell polarity. Controlling intracellular localization of Par1b is important for its biological activity. We previously reported that Wnt stimulation or expression of Dvl promo...
Yosuke Funato, Yosuke Funato, Yosuke Funato, Tatsuo Michiue, Tatsuo Michiue, Takeshi Terabayashi, Akira Yukita, Hiroki Danno, Hiroki Danno, Makoto Asashima, Makoto Asashima, Makoto Asashima, Hiroaki Miki
Genes to Cells   13(9) 965-975   Sep 2008   [Refereed]
The Wnt signaling pathway is conserved across species, and is essential for early development. We previously identified nucleoredoxin (NRX) as a protein that interacts with dishevelled (Dvl) in vivo to negatively regulate the Wnt/β-catenin pathway...
Takeshi Terabayashi, Tomohiko J. Itoh, Hideki Yamaguchi, Yuta Yoshimura, Yosuke Funato, Shigeo Ohno, Hiroaki Miki, Hiroaki Miki
Journal of Neuroscience   27(48) 13098-13107   Nov 2007   [Refereed]
Neurons are highly polarized cells that possess two morphologically and functionally different types of protrusions, axons and dendrites, that function in the transmission and reception of neural signals, respectively. A great deal of attention ha...


木村 俊秀, 姫野 冴美, 山岡 真美, 寺林 健, 石崎 敏理
糖尿病   61(Suppl.1) S-317   Apr 2018
寺林 健, 石崎 敏理
和漢医薬学総合研究所年報   44 139-139   Mar 2018
山岡 真美, 寺林 健, 石崎 敏理, 木村 俊秀
生命科学系学会合同年次大会   2017年度 [1P-1151]   Dec 2017
山岡 真美, 荒巻 千香子, 姫野 冴美, 寺林 健, 石崎 敏理, 木村 俊秀
糖尿病   60(Suppl.1) S-259   Apr 2017
安部 一太郎, 手嶋 泰之, 寺林 健, 石崎 敏理, 高橋 尚彦
日本病態生理学会雑誌   25(2) 56-56   Jul 2016
石崎 敏理, 寺林 健
医薬ジャーナル   52(6) 1489-1494   Jun 2016
山岡 真美, 姫野 冴美, 寺林 健, 石崎 敏理, 木村 俊秀
糖尿病   59(Suppl.1) S-354   Apr 2016
山岡 真美, 寺林 健, 松永 耕一, 泉 哲郎, 仁木 一郎, 石崎 敏理, 木村 俊秀
日本生化学会大会・日本分子生物学会年会合同大会講演要旨集   88回・38回 [2P0046]-[2P0046]   Dec 2015
山岡 真美, 安藤 朋海, 寺林 健, 松永 耕一, 泉 哲郎, 仁木 一郎, 石崎 敏理, 木村 俊秀
糖尿病   58(Suppl.1) S-441   Apr 2015
岡本 光弘, 山岡 真美, 武井 真大, 安藤 朋海, 寺林 健, 石井 功, 石崎 敏理, 仁木 一郎, 木村 俊秀
日本内分泌学会雑誌   90(1) 267-267   Apr 2014
岡本 光弘, 山岡 真美, 安藤 朋海, 寺林 健, 仁木 一郎, 石崎 敏理, 木村 俊秀
糖尿病   57(Suppl.1) S-263   Apr 2014
山岡 真美, 岡本 光弘, 安藤 朋海, 寺林 健, 松永 耕一, 泉 哲郎, 仁木 一郎, 石崎 敏理, 木村 俊秀
糖尿病   57(Suppl.1) S-405   Apr 2014
寺林 健, 西中村 隆一
日本生化学会大会プログラム・講演要旨集   84回 4P-0131   Sep 2011
診断の指針治療の指針 腎臓の発生と再生
寺林 健, 西中村 隆一
綜合臨床   58(8) 1829-1831   Aug 2009

Conference Activities & Talks

第41回 日本分子生物学会年会   2018   
第61回 日本糖尿病学会年次学術集会   2018   
Role of Rho-mDia1 Signaling to Maintain Cardiac Function in Response to Pressure Overload in Mice
Abe I., Teshima Y., Yonehara Y., Kaku H., Kira S., Oniki T., Ikebe Y., Kondo H., Saito S., Terabayashi T., Ishizaki T., and Takahashi N.
第82回日本循環器学会   2018   
2017年度生命科学系学会合同年次大会   2017   
第60回 日本糖尿病学会年次学術集会   2017   
Role of Rho-mDia1 Signaling in the Pressure Overload-Induced Cardiac Hypertrophic Response.
Abe I., Teshima Y., Yonehara Y., Kaku H., Kira S., Oniki T., Ikebe Y., Kondo H., Saito S., Terabayashi T., Ishizaki T., and Takahashi N.
第81回日本循環器学会学術集会   2017   
第90回 日本薬理学会年会   2017   
第90回 日本薬理学会年会   2017   
第90回 日本薬理学会年会   2017   
第39回 日本分子生物学会年会   2016   
Molecular Cardiovascular Conference II   2016   
第59回 日本糖尿病学会年次学術集会   2016   
第38回 日本分子生物学会年会   2015   
第88回 日本薬理学会年会   2015   
Endogenous hydrogen sulfide protects pancreatic beta-cells from a high-fat diet-induced glucotoxicity and prevents the development of type 2 diabetes.
Okamoto M., Yamaoka M., Ando T., Takei M., Taniguchi S., Terabayashi T., Niki I., Ishizaki T. and Kimura T.
3rd International Conference on Hydrogen Sulfide in Biology and Medicine   2014   
第57回日本糖尿病学会年次学術集会   2014   
第57回日本糖尿病学会年次学術集会   2014   
第87回日本薬理学会年会   2014   
Phosphorylation of Kif26b promotes its polyubiquitination and subsequent proteasomal degradation during kidney development.
Terabayashi T. Sakaguchi M. and Nishinakamura R.
The 34th Annual Meeting of Molecular Biology Society of Japan   2011   
第84回日本生化学会大会   2011   
NucleoredoxinはDishevelled蛋白質の安定性を制御することによってWnt/b-catenin経路の活性を維持している(Nucleoredoxin regulates the intensity of the Wnt/β-catenin pathway through stabilization of Dishevelled)
船戸 洋佑, 寺林 健, 吉田 進昭, 三木 裕明
日本細胞生物学会大会講演要旨集   May 2010   
NucleoredoxinはFlightless-Iを介してTLR4/MyD88経路を負に制御する(Nucleoredoxin regulates Toll-like receptor 4 signaling via recruitment of Flightless-I to myeloid differentiation primary response gene (88))
林 達也, 船戸 洋佑, 寺林 健, 森中 紹文, 吉田 進昭, 三木 裕明
日本細胞生物学会大会講演要旨集   May 2010   
第62回日本細胞生物学会大会   2010   
Par1b/MARK2によるキネシンスーパーファミリーGAKIN/KIF13Bのリン酸化は神経極性を制御する(Phosphorylation of kinesin super family GAKIN/KIF13B by Par1b/MARK2 regulates neuronal polarity)
吉村 祐太, 寺林 健, 三木 裕明
日本細胞生物学会大会講演要旨集   May 2009   
第61回日本細胞生物学会   2009   
Fz5のエンドサイトーシスにおける新規Dvl結合蛋白質p100の役割(A novel Dvl interacting protein p100 promotes internalization of Fz5 via the clathrin-dependent pathway and lysosomal degradation)
寺林 健, 船戸 洋佑, 三木 裕明
日本細胞生物学会大会講演要旨集   Jun 2008   
NucleoredoxinによるWnt/PCP経路の制御(Nucleroredoxin regulates Wnt/planar cell polarity pathway in Xenopus)
船戸 洋佑, 道上 達男, 寺林 健, 雪田 聡, 團野 宏樹, 浅島 誠, 三木 裕明
日本細胞生物学会大会講演要旨集   Jun 2008   
細胞接着・細胞外基質・細胞間相互作用 海馬ニューロン上の樹状突起形成における極性制御キナーゼPar1b/MARK2による負の制御(Polarity-regulating kinase Par1b/MARK2 negatively regulates development of dendrites on hippocampal neurons)
寺林 健, 伊藤 知彦, 山口 英樹, 大野 茂男, 三木 裕明
日本発生生物学会・日本細胞生物学会合同大会要旨集   May 2007   
第30回日本分子生物学会年会・第80回日本生化学会大会合同大会   2007   

Research Grants & Projects