CHO Hidetsura

J-GLOBAL         Last updated: Nov 9, 2018 at 15:34
 

Research Areas

 
 

Academic & Professional Experience

 
2012
 - 
Today
Professor of Graduate School of Pharmaceutical Sciences, Tohoku Univ., Graduate School of Pharmaceutical Sciences
 

Education

 
 
 - 
1978
Kyoto University
 
 
 - 
1973
Kyoto University
 

Committee Memberships

 
2003
   
 
日本プロセス化学会  理事
 
2004
 - 
2004
日本プロセス化学会2004サマーシンポジウム(京都)  組織委員長(世話人)
 

Awards & Honors

 
1988
有機合成化学協会奨励賞(近畿支部賞)
 

Published Papers

 
H. Cho, Y. Nishimura, H. Ikeda, M. Asakura, S. Toyota
Tetrahedron   74 2405-2413   2018   [Refereed]
CHO Hidetsura
Tetrahedron (Report: Review)   70, 3527-3544   May 2014   [Refereed]
Y. Iwama, T. Noro, K. Okano, H.Cho, H. Tokuyama
Heterocycles   88, 1433-1444   2014   [Refereed]
Dihydropyrimidine (Review)
CHO Hidetsura
Heterocycles   87, 1441-1479   2013   [Refereed]
H. Cho, Y. Nishimura, Y. Yasui, M. Yamaguchi
Tetrahedron Lett.   53, 1177-1179   2012   [Refereed]
Y. Nishimura, Y. Yasui, S. Kobayashi, M. Yamaguchi, H. Cho
Tetrahedron   68, 3342-3350   2012   [Refereed]
H. Cho, Y. Iwama, N. Mitsuhashi, K. Sugimoto, K. Okano, H. Tokuyama
Molecules   17, 7348-7355   2012   [Refereed]
H. Cho, E. Kwon, Y. Yasui, S. Kobayashi, S. Yoshida, Y. Nishimura, M.Yamaguchi
Tetrahedron Lett.   52, 7185-7188   2011   [Refereed]

Misc

 
Y. Nishimura, T. Kubo, Y. Okamoto, H.Cho
Tetrahedron Lett.   58 4236-4239   2017   [Refereed]
H. Cho, Y. Nishimura, Y. Yasui, M.Yamaguchi
Tetrahedron Letters      2011
H. Cho, Y. Nishimura, Y. Yasui, S. Kobayashi, S. Yoshida, E. Kwon, M. Yamaguchi
Tetrahedron   67(14) 2661-2669   2011
H. Cho, E. Kwon, Y. Yasui, S. Kobayashi, S. Yoshida, Y. Nishimura, M.Yamaguchi
Tetrahedron Letters   52(52) 7185-7188   2011

Books etc

 
Creative Pharmaceutical Sciences --- Discovery and Development of New Medicines
Hidetsura CHO
Nanzando   Aug 2012   ISBN:978-4-525-73011-6
Before the translation, I briefly introduce the content of the book.
I. Discovery and Development of Clinical Candidates
(1) Nowadays of Pharmaceutical Field in Japan, US and Europe
(2) Organization of Research Institutes and Flow and Steps of R &...
実践・医薬品化学
南山堂   2012   
医薬品のプロセス化学
化学同人   2005   ISBN:978-4-7598-0986-2

Conference Activities & Talks

 
Invited Lecture; The New Synthetic Method Using DIBALH for the Fundamental Skeletons of Medicines or Clinical Candidates and Chemistry of Dihydropyrimidines
Hidetsura Cho
Lecture in Patras University (Invited from Prof. Plato A. Magriotis, Patras, Greece)   8 Jul 2013   
Novel synthetic approach toward the core structures of medicines and clinical candidates. Regiospecific rearrangement of oxime or hydroxylamine using diisobutylaluminum hydride (DIBALH).
Hidetsura Cho,* Yusuke Iwama, Nakako Mitsuhashi, Kenji Sugimoto, Kentaro Okano, Hidetoshi Tokuyama
RICT 2013 - 49th International Conference on Medicinal Chemistry (Nice, France)   4 Jul 2013   
Novel synthetic approach toward the core structures of medicines and clinical candidates. Regiospecific rearrangement of oxime or hydroxylamine using diisobutylaluminum hydride (DIBALH).
Hidetsura Cho,* Yusuke Iwama, Nakako Mitsuhashi, Kenji Sugimoto, Kentaro Okano, Hidetoshi Tokuyama
EFMC-ISMC2012, XXIInd International Symposium on Medicinal Chemistry (Berlin, Germany)   5 Sep 2012   
Construction of dihydropyrimidine skeleton using 1,2,4-trisubstituted-1,3-diaza-1,3-
Hidetsura Cho,* Yoshio Nishimura, Yoshizumi Yasui, Satoshi Kobayashi, Masahiko Yamaguchi
6th Spanish-Portuguese-Japanese Organic Chemistry Symposium (6th. SPJ-OCS)(Lisbon, Portugal)   19 Jul 2012   
Invited Lecture; The New Synthetic Method Using DIBALH for the Fundamental Skeletons of Medicines or Clinical Candidates, and Some Examples of Pharmaceutical Process Chemistry
Hidetsura Cho
Lecture; Invited from Dr. Irena Stara in Academy of Sciences of the Czech Republic   16 Sep 2011   
Regioselective Synthesis of Nitrogen-Containing Heterocycles by Ring-Expansion Reaction of Oximes or Hydroxylamines with Aluminum Reductants
Hidetsura Cho,* Yusuke Iwama, Nakako Mitsuhashi, Kenji Sugimoto, Kentaro Okano, Hidetoshi Tokuyama
FJS 2011 (22nd French-Japanese Symposium on Medicinal and Fine Chemistry) (Rouen, France)   12 Sep 2011   
Invited Lecture; The New Synthetic Method for the Fundamental Skeletons of Medicines or Clinical Candidates, and Some Examples of Pharmaceutical Process Chemistry
Hidetsura Cho
Lecture, Invited from Prof. D. H. Hua, Kansas State University (Kansas, USA)   8 Aug 2011   
Regioselective Synthesis of Nitrogen-Containing Heterocycles by Ring-Expansion Reaction of Oximes or Hydroxylamines with Aluminum Reductants
FJS 2011 (22nd French-Japanese Symposium on Medicinal and Fine Chemistry)   2011   
Synthesis of novel dihydropyrimidine derivatives by substitution reaction at position-2 and 4
Hidetsura Cho,* Yoshio Nishimura, Yoshizumi Yasui, Satoshi Kobayashi,
The 23rd International Congress on Heterocyclic Chemistry (ICHC-23) (Glasgow, Scotland)   2 Aug 2011   
Invited Lecture; The New Synthetic Method for the Fundamental Skeletons of Medicines or Clinical Candidates, and Some Examples of Pharmaceutical Process Chemistry
Hidetsura Cho
Lecture; Invited from Prof. Marc Tius in Hawaii University (Hawaii, USA)   20 Dec 2010   
Invited Lecture; The New Synthetic Method for the Fundamental Skeletons of Medicines or Clinical Candidates, and Some Examples of Pharmaceutical Process Chemistry
Hidetsura Cho
Lecture; Invited from Director Dr. Gyula Simig in EGIS Ltd. (Budapest, Hungary)   31 Aug 2010   
The New Synthetic Method for the Fundamental Skeletons of Medicines or Clinical Candidates, and Some Examples of Pharmaceutical Process Chemistry
Hidetsura Cho
Lecture; Invited from Dr. Zsuzsanna Kardos in QUINOIN Ltd. (Budapest, Hungary)   30 Aug 2010   
Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring using diisobutylaluminum hydride (DIBALH) and studies on the reaction mechanism
Hidetsura Cho,* Yusuke Iwama, Nakako Mitsuhashi, Seiji Mori,
XXIVth European Colloquium on Heterocyclic Chemistry (ECHC) (Vienna, Austria)   24 Aug 2010   
Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring using diisobutylaluminum hydride (DIBALH) and studies on the reaction mechanism
Hidetsura Cho, Kenji Sugimoto,* Yusuke Iwama, Nakako Mitsuhashi , Kentaro Okano, Seiji Mori, Hidetoshi Tokuyama
FJS2010 (21st French-Japanese Symposium on Medicinal and Fine Chemistry) (Kyoto, Japan))   9 May 2010   
Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring using diisobutylaluminum hydride (DIBALH) and studies on the reaction mechanism
XXIVth European Colloquium on Heterocyclic Chemistry (ECHC)   2010   
Regioselective synthesis of heterocycles containing nitrogen neighboring an aromatic ring using diisobutylaluminum hydride (DIBALH) and studies on the reaction mechanism
FJS2010 (21st French-Japanese Symposium on Medicinal and Fine Chemistry)   2010   
Regioselective synthesis of unsubstituted basic skeletons of heterocycles containing nitrogen neighboring an aromatic ring by the reductive ring expansion reaction using diisobutylaluminum hydride (DIBAH)
Hidetsura Cho,* Yusuke Iwama, Kenji Sugimoto, Seiji Mori, Eunsang Kwon, Hidetoshi Tokuyama
ICHC-22/22nd International Congress on Heterocyclic Chemistry (St. John's, Canada)   3 Aug 2009   
Regioselective synthesis of unsubstituted basic skeletons of heterocycles containing nitrogen neighboring an aromatic ring by the reductive ring expansion reaction using diisobutylaluminum hydride (DIBAH)
ICHI-22、国際複素環化学会議   2009   
A novel K+ channel opener; JTV-506, a selective coronary vasodilator
AIMECS 95/AFMC 国際メデイシナルケミストリーシンポジウム   1995   
Novel caffeic acid derivatives: Potent inhibitors of 12-lipoxygenase
第7回プロスタグランジン及び関連化合物に関する国際会議   1990   
Dihydropyrimidine: Novel calcium antagonist possessing a potent and longlasting anti- hypertensive activity
第10回国際メデイシナルケミストリーシンポジウム   1988   
Synthesis of novel 5-alkoxycarbonyl-5,6-dihydropyrimidin-4-(3H)-ones
第10回国際複素環化学会議   1985   

Works

 
新規ジヒドロピリミジン誘導体の合成研究
2008

Patents

 
Synthesis of benzothiophene-fused diazepinones as antiviral agents (HSV)
WO 2002014324
Preparation of five-membered fused heterocyclic azepine derivatives as drugs
WO 9717349
Preparation of caffeic acid amide derivatives as 12-lipoxygenase inhibitors
JP 06247850
Preparation of fused five-membered heterocycloazepine compounds as vasopressin antagonists
JP 09020779
Preparation of chroman derivatives as coronary vasodilators
WO 9502588
Preparation of heterocyclylamino-chroman derivatives and analogs as cardiovascular agents
WO 9502589
Preparation of pyrroloazepines as cardiovascular agents
JP 05097856
Preparation of caffeic acid derivatives as 12-lipoxygenase inhibitors
JP 05331129
Preparation of pyrroloazepines as intermediates for anti-α1 and antiserotonin agents
JP 05025128
Preparation of caffeic acid amides as 12-lipoxygenase inhibitors
JP 05058978
Preparation of pyrroloazepine derivatives as cardiovascular agents
WO 9303031
1-Substituted pyrrolizidine derivatives
JP 1992-1706271
Preparation and formulation of caffeic acid derivatives as 12-lipoxygenase inhibitors
JP 01275552, US 5063243, EP 339671
N-Substituted 3,4-dihydropyrimidine derivatives as calcium antagonists
JP 63208580, US 4920124, EP 280227
Preparation and pharmaceutical compositions of 1,4-dihydropyridine-3,5- dicarboxylate derivatives for treatment of circulation disorders
JP 62005958, US 4824837, EP 207514
N-Substituted 3,4-dihydropyrimidinedicarboxylate derivatives, compositions containing them for treatment cardiovascular disorders, and a process for their preparation
JP 62005968, US 4772602, EP 195374
3N-Substituted 3,4-dihydropyrimidine derivatives
JP 60214778, US 4640922, EP 157219
N-Substituted 3,4-dihydropyrimidine derivatives and pharmaceutical compositions
JP 60246376, US 4683234, EP 162208