Taku Nedachi

Profile Information

Affiliation: Resercher, Faculty of Life Sciences, Toyo University

Degree: 博士（農学）(東京大学)

Researcher number: 50375200
J-GLOBAL ID: 200901015891343448
researchmap Member ID: 6000011907

Research Interests

Research Areas

Research History

2012 - Present

Faculty of Life Sciences, Department of Applied Biosciences, Toyo University
2016 - 2017

客員研究員, フランス国立科学研究センター（CNRS）
2016 - 2016

招聘教授, クロード・ベルナールリヨン第1大学
2010 - 2012

Faculty of Life Sciences, Department of Applied Biosciences, Toyo University
2008 - 2010

特任研究員, 農学生命科学研究科, 東京大学大学院
2004 - 2008

Biomedical Engineering Research Organization, Tohoku University
2001 - 2004

博士研究員, 医学系研究科, スタンフォード大学
2000 - 2001

博士研究員, 農学生命科学研究科, 東京大学大学院

Education

1995 - 2000

応用動物科学専攻, 農学生命科学研究科, 東京大学大学院
1991 - 1995

The University of Tokyo

Papers

Chronological aging impacts abundance, function and microRNA content of extracellular vesicles produced by human epidermal keratinocytes

Taku Nedachi, Christelle Bonod, Julie Rorteau, Wafae Chinoune, Yuri Ishiuchi, Sandrine Hugues, Benjamin Gille, Dominique Sigaudo-Roussel, Jerome Lamartine

Aging (Albany NY), In press., Oct, 2023 Peer-reviewedLead author
Identification of C-C motif chemokine ligand 5 as a heat-dependent myokine

Keigo Murata, Yuri Ishiuchi-Sato, Taku Nedachi

Endocrine Journal, 70(6) 601-610, Jun, 2023 Peer-reviewedLast authorCorresponding author
Possible involvement of CXC motif chemokine ligand 10 in exercise-induced collagen production of mouse dermal fibroblasts

Yuri Ishiuchi-Sato, Taku Nedachi

Endocrine Journal, 68(11) 1359-1365, Nov, 2021 Peer-reviewedLast authorCorresponding author
Hydrogen peroxide induces progranulin expression to control neurite outgrowth in HT22 cells.

Ayumu Shimoda, Takemi Tanabe, Tsubasa Sato, Taku Nedachi

Biosci Biotechnol Biochem., 85(10) 2103-2112, Sep, 2021 Peer-reviewedLast authorCorresponding author
The effects of glucose and fatty acids on CXCL10 expression in skeletal muscle cells

Yuri Ishiuchi-Sato, Erika Hiraiwa, Ayaka Shinozaki, Taku Nedachi

Bioscience, Biotechnology, and Biochemistry, 84(12) 2448-2457, Dec, 2020 Peer-reviewedLast authorCorresponding author
運動依存性マイオカインと代謝機能

根建拓, 石内友里

「骨格筋研究を核とした筋スマート社会」（シーエムシー・リサーチ）, Jun, 2019 InvitedLead authorCorresponding author
Neural Stem/Progenitor Cells and Progranulin

Nedachi T

Progranulin and Central Nervous System Disorders (Springer Nature Singapore Pte Ltd.), May, 2019 Peer-reviewedInvitedLead authorLast authorCorresponding author
Identification of CCL5/RANTES as a novel contraction-reducible myokine in mouse skeletal muscle

Yuri Ishiuchi, Hitoshi Sato, Narumi Komatsu, Hideo Kawaguchi, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara, Taku Nedachi

Cytokine, 108(8) 17-23, Aug 1, 2018 Peer-reviewedLast authorCorresponding author
Skeletal muscle cell contraction reduces a novel myokine, chemokine (C-X-C motif) ligand 10 (CXCL10): Potential roles in exercise-regulated angiogenesis

Yuri Ishiuchi, Hitoshi Sato, Kazuki Tsujimura, Hideo Kawaguchi, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara, Taku Nedachi

Bioscience, Biotechnology and Biochemistry, 82(1) 97-105, 2018 Peer-reviewedLast authorCorresponding author
Glucose deprivation regulates the progranulin-sortilin axis in PC12 cells

Ken-ichi Kawashima, Yuri Ishiuchi, Miki Konnai, Saori Komatsu, Hitoshi Sato, Hideo Kawaguchi, Nobumitsu Miyanishi, Jerome Lamartine, Masugi Nishihara, Taku Nedachi

FEBS OPEN BIO, 7(2) 149-159, Feb, 2017 Peer-reviewedLast authorCorresponding author
Glucose deprivation attenuates sortilin levels in skeletal muscle cells

Miyako Ariga, Yosuke Yoneyama, Toshiaki Fukushima, Yuri Ishiuchi, Takayuki Ishii, Hitoshi Sato, Fumihiko Hakuno, Taku Nedachi, Shin-Ichiro Takahashi

ENDOCRINE JOURNAL, 64(3) 255-268, 2017 Peer-reviewed
Glutamate levels control HT22 murine hippocampal cell death by regulating biphasic patterns of Erk1/2 activation: role of metabolic glutamate receptor 5

Kazunori Sato, Yuki Yamanaka, Yasuharu Asakura, Taku Nedachi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 80(4) 712-718, Apr, 2016 Peer-reviewedLast authorCorresponding author
Dual cell protective mechanisms activated by differing levels of oxidative stress in HT22 murine hippocampal cells

Kazunori Sato, Yuki Yamanaka, Masaya Ishii, Kazusa Ishibashi, Yurina Ogura, Ritsuko Ohtani-Kaneko, Masugi Nishihara, Taku Nedachi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 78(9) 1495-1503, Sep, 2014 Peer-reviewedLast authorCorresponding author
Lysine suppresses protein degradation through autophagic-lysosomal system in C2C12 myotubes

Tomonori Sato, Yoshiaki Ito, Taku Nedachi, Takashi Nagasawa

MOLECULAR AND CELLULAR BIOCHEMISTRY, 391(1-2) 37-46, Jun, 2014 Peer-reviewed
Subtoxic levels of hydrogen peroxide induce brain-derived neurotrophic factor expression to protect PC12 cells

Yurina Ogura, Kazunori Sato, Ken-Ichi Kawashima, Nanako Kobayashi, Sei Imura, Kotaro Fujino, Hideo Kawaguchi, Taku Nedachi

BMC Research Notes, 7(1) 840, 2014 Peer-reviewedLast authorCorresponding author
Potential neuroprotective effects of SIRT1 induced by glucose deprivation in PC12 cells

Kotaro Fujino, Yurina Ogura, Kazunori Sato, Taku Nedachi

NEUROSCIENCE LETTERS, 557(B) 148-153, Dec, 2013 Peer-reviewedLast authorCorresponding author
Characterization of contraction-induced IL-6 up-regulation using contractile C2C12 myotubes

Arta Farmawati, Yasuo Kitajima, Taku Nedachi, Masaaki Sato, Makoto Kanzaki, Ryoichi Nagatomi

ENDOCRINE JOURNAL, 60(2) 137-147, Feb, 2013 Peer-reviewed
Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells

Daisuke Yamanaka, Takeshi Akama, Toshiaki Fukushima, Taku Nedachi, Chie Kawasaki, Kazuhiro Chida, Shiro Minami, Koichi Suzuki, Fumihiko Hakuno, Shin-Ichiro Takahashi

MOLECULAR ENDOCRINOLOGY, 26(6) 1043-1055, Jun, 2012 Peer-reviewed
PROGRANULIN ENHANCES NEURAL PROGENITOR CELL PROLIFERATION THROUGH GLYCOGEN SYNTHASE KINASE 3 beta PHOSPHORYLATION

T. Nedachi, T. Kawai, T. Matsuwaki, K. Yamanouchi, M. Nishihara

NEUROSCIENCE, 185 106-115, Jun, 2011 Peer-reviewedLead author
神経変性とTDP43・プログラニュリンプログラニュリンと行動・神経変性

根建拓, 松脇貴志, 西原真杉

Cogn Dement, 10(2) 140-146, Apr 30, 2011 Lead author

Misc.

MiR-30a is an aged-related microRNA that impairs differentiation and induces apoptosis in human epidermis

C. Muther, M. Garion, L. Jobeili, O. Damour, T. Nedachi, J. Lamartine

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 137(10) S208-S208, Oct, 2017
Comparative analysis of N-glycans in skeletal muscle cells and its exercise condition

Takumi Wakisaka, Hitoshi Sato, Takayuki Ishii, Risa Horiuchi, Taku Nedachi, Nobumitsu Miyanishi

GLYCOBIOLOGY, 26(12) 1416-1416, Dec, 2016
神経前駆細胞におけるプログラニュリンの生理作用の解析

根建拓, 河合隆徳, 松脇貴志, 山内啓太郎, 西原真杉

日本獣医学会学術集会講演要旨集, 149th 298, 2010
Roles of Progranulin in Sexual Differentiation of the Developing Brain and Adult Neurogenesis

Masatoshi Suzuki, Hwi-Cheul Lee, Yuko Kayasuga, Shuichi Chiba, Taku Nedachi, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara

JOURNAL OF REPRODUCTION AND DEVELOPMENT, 55(4) 351-355, Aug, 2009
成長因子プログラニュリンの神経保護作用の解析

河合隆徳, 根建拓, 松脇貴志, 山内啓太郎, 西原眞杉

日本獣医学会学術集会講演要旨集, 147th 284, Mar 1, 2009
F-15 Electrical pulse stimulation of C2C12 cultured myotubes induces IL-6 production(Free communication (Slide),8^<TH> INTERNATIONAL SOCIETY OF EXERCISE AND IMMUNOLOGY SYMPOSIUM,ISEI2007 INFLAMMATION IN EXERCISE FRIEND OR FOE?)

Farmawati Arta, Nedachi Taku, Kanzaki Makoto, Nagatomi Ryoichi

Japanese Journal of Physical Fitness and Sports Medicine, 58(1) 190-190, Feb 1, 2009
Identification of contraction-inducible myokines and their impact on insulin responsive GLUT4 translocation in C2C12 myotubes

Taku Nedachi, Hideaki Fujita, Makoto Kanzaki

DIABETES, 57 A308-A308, Jun, 2008
Functional role of sortilin in myogenesis and development of insulin-responsive glucose transport system in C2C12 myocytes

Miyako Ariga, Taku Nedachi, Hideki Katagiri, Makoto Kanzaki

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(15) 10208-10220, Apr, 2008
生細胞内におけるGLUT4分子動態ナノイメージングとインスリン作用機構

藤田英明, 渡邉朋信, 根建拓, 樋口秀男, 神崎展

日本学術会議材料工学連合講演会講演論文集, 51st 107, Nov 27, 2007
3P325 Live cell imaging of the movement of GLUT4 molecule in highly differentiated C2C12 myotubes.(Bioimaging,Poster Presentations)

Fujita Hideaki, Watanabe Tomonobu, Nedachi Taku, Higuchi Hideo, Kanzaki Makoto

Biophysics, 47(1) S284, Nov 20, 2007
Single molecule analysis of insulin-induced GLUT4 behavior in 3T3L1 adipocyte using Qdot nano-crystals

Hideaki Fujita, Tomonobu Watanabe, Taku Nedachi, Hideo Higuchi, Makoto Kanzaki

DIABETES, 56 A330-A330, Jun, 2007
Functional role of sortilin in myogenesis and the development of insulin-responsive glucose transport system in C2C12 myocytes

Miyako Ariga, Taku Nedachi, Hideki Katagiri, Makoto Kanzaki

DIABETES, 56 A36-A37, Jun, 2007
Accelerated de novo sarcomere assembly by electric pulse stimulation in C2C12 myotubes

Hideaki Fujita, Taku Nedachi, Makoto Kanzaki

EXPERIMENTAL CELL RESEARCH, 313(9) 1853-1865, May, 2007
擬似的運動刺激によるインスリン依存的なGLUT4膜移行増強機構の解析〜高度発達型筋管細胞の作製と応用〜

根建拓, 藤田英明, 神崎展

糖尿病, 50(Supplement 1) S.259, Apr 25, 2007
多彩な生理作用を制御するドッキングタンパク質の分子進化

根建拓

実験医学, 25(16) 2518-2519, 2007
セラミド合成とインスリン抵抗性

根建拓

実験医学, 25(9) 1331-1332, 2007
生体の代謝環境を改善するResveratrol

根建拓

実験医学, 25(3) 381-382, 2007
高度発達型培養筋管細胞の作製技術とその糖尿病研究への利用

根建拓, 藤田英明, 神崎展

日本生体医工学会大会プログラム・論文集(CD−ROM), 46th ROMBUNNO.PS1-1-4, 2007
Qdotを用いた細胞膜表面でのGLUT4分子動態TIRF観察

藤田英明, 渡邉朋信, 根建拓, 樋口秀男, 神崎展

日本生体医工学会大会プログラム・論文集(CD−ROM), 46th ROMBUNNO.PS3-4-12, 2007
Protein kinase B/Akt phosphorylation of PDE3A and its role in mammalian oocyte maturation

Seung Jin Han, Sergio Vaccari, Taku Nedachi, Carsten B. Andersen, Kristina S. Kovacina, Richard A. Roth, Marco Conti

EMBO JOURNAL, 25(24) 5716-5725, Dec, 2006

Books and Other Publications

新時代の糖尿病学

日本臨床社, 2008

Teaching Experience

Professional Memberships

Works

NHK サイエンスZERO 第113回「筋肉があなたを救う」

2006

Research Projects

運動による骨格筋由来エクソソームの制御および機能変化の解明

科学研究費補助金(基盤研究(C)), Apr, 2019 - Mar, 2022

根建拓
Elucidation of motor dysfunction based on galectin network and lifestyle risk diagnosis

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Oct, 2016 - Mar, 2019

Miyanishi Nobumitsu
骨格筋収縮依存的な分泌タンパク質による免疫機能制御機構の解明

科学研究費補助金(基盤研究(C)), Apr, 2016 - Mar, 2019

根建拓
脳内成長因子の生理作用と病態に関する研究

科学研究費補助金(基盤研究(S)), Apr, 2011 - Mar, 2016

西原真杉
Application of in vitro C2C12 contractile model that mimics different types of exercise

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2015

NEDACHI Taku, KAWAGUCHI Hideo
Effects of mechanical stresses on neural stem/progenitor cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, Apr, 2010 - Mar, 2012

NEDACHI Taku
生体材料・医用材料として有用な培養細胞由来骨格筋モデルの創製

科学研究費補助金(特定領域研究), 特定領域研究, 日本学術振興会, Apr, 2008 - Mar, 2010

根建拓, 神崎展
Characterization of novel exercise factors in skeletal muscle

Grants-in-Aid for Scientific Research(若手研究(B)), 若手研究(B), Ministry of Education, Culture, Sports, Science and Technology, Apr, 2008 - Mar, 2010

Taku NEDACHI
収縮筋細胞における糖輸送担体GLUT4の分子挙動解析

科学研究費補助金(特定領域研究), 特定領域研究, 日本学術振興会, Apr, 2007 - Mar, 2009

神崎展, 藤田英明, 根建拓
Analysis of proteins regulating GLUT4 translocation

Grants-in-Aid for Scientific Research(基盤研究(B)), 基盤研究(B), Japan Society for the Promotion of Science, 2006 - 2008

Makoto KANZAKI, 藤田英明, 根建拓
Role of Progranulin in CNS

Grant-in-Aid for Scientific Research, 2008
高度発達型筋細胞系を用いた運動刺激依存的なGLUT4膜移行制御機構の解明

科学研究費補助金(若手研究(B)), 若手研究(B), 日本学術振興会, 2006 - 2007

根建拓
糖代謝能研究に適した高度分化型培養筋管細胞系の確立

科学研究費補助金(萌芽研究), 萌芽研究, 日本学術振興会, 2005 - 2006

神崎展, 藤田英明, 根建拓
ナノテクノロジーを駆使したインスリン依存性糖輸送システムの統合的解析

科学研究費補助金(特定領域研究), 特定領域研究, 日本学術振興会, 2005 - 2006

神崎展, 藤田英明, 根建拓

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