論文

国際誌
2021年4月30日

Testosterone interrupts binding of Neurexin and Neuroligin that are expressed in a highly socialized rodent, Octodon degus.

Biochemical and biophysical research communications
  • Nan Yagishita-Kyo
  • ,
  • Yuki Ikai
  • ,
  • Tomoko Uekita
  • ,
  • Akio Shinohara
  • ,
  • Chihiro Koshimoto
  • ,
  • Keisuke Yoshikawa
  • ,
  • Kei Maruyama
  • ,
  • Sosuke Yagishita

551
開始ページ
54
終了ページ
62
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2021.03.015

Octodon degus is said to be one of the most human-like rodents because of its improved cognitive function. Focusing on its high sociality, we cloned and characterized some sociality-related genes of degus, in order to establish degus as a highly socialized animal model in molecular biology. We cloned degus Neurexin and Neuroligin as sociality-related genes, which are genetically related to autism spectrum disorder in human. According to our results, amino acid sequences of Neurexin and Neuroligin expressed in degus brain, are highly conserved to that of human sequences. Most notably, degus Neuroligin4 is highly similar to human Neuroligin4X, which is one of the most important autism-related genes, whereas mouse Neuroligin4 is known to be poorly similar to human Neuroligin4X. Furthermore, our work also indicated that testosterone directly binds to degus Neurexin and intercepts intercellular Neurexin-Neuroligin binding. Moreover, it is of high interest that testosterone is another key molecule of the higher incidence of autism in male. These results indicated that degus has the potential for animal model of sociality, and furthermore may promote understanding toward the pathogenic mechanism of autism.

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2021.03.015
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/33721831
ID情報
  • DOI : 10.1016/j.bbrc.2021.03.015
  • PubMed ID : 33721831

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