Kazuharu Misawa

J-GLOBAL         Last updated: Jan 7, 2020 at 09:54
 
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Name
Kazuharu Misawa
Affiliation
Kansai Medical University
Section
Institute of Biomedical Science
Job title
Researcher
Research funding number
10525885
ORCID ID
0000-0002-6277-4330

Research Areas

 

Academic & Professional Experience

 
Feb 2019
 - 
Today
Lecturer, Kansai Medical University
 
May 2015
 - 
Jan 2019
Assistant Professor, Tohoku Medical Megabank Organization, Tohoku University
 
Apr 2013
 - 
Apr 2015
Research Scientist, Advanced Center for Computing and Communication, Riken
 
Nov 2007
 - 
Mar 2013
Research Scientist, Research Program for Computational Science, Riken
 
Oct 2010
 - 
Feb 2010
Lecturer, Graduate School of Science, Kobe University
 

Education

 
Apr 1995
 - 
Sep 2000
Department of Biological Sciences, Graduate School of Science, The University of Tokyo
 
Apr 1991
 - 
Mar 1995
Faculty of Science, Kyoto University
 
Apr 1990
 - 
Mar 1991
Natural Sciences I, The College of Arts and Sciences, The University of Tokyo
 
Apr 1987
 - 
Mar 1990
General Course, Niigata Senior High School
 

Awards & Honors

 
2011
Top Reviewer in 2011, Molecular Phylogenetics and Evolution
 

Published Papers

 
Kazuharu Misawa, Hiroshi Watanabe, Akio Yokoseki, Minako Wakasugi, Osamu Onodera, Ichiei Narita, Takeshi Momotsu, Kenji Sato, Naoto Endo
Human Genome Variation   6(1) 26   Jun 2019   [Refereed]
To explore the effect of aging, a cohort study is being performed on Sado Island, which is located in the Sea of Japan. Sado Island is close to the eastern coast of Japan, yet its population speaks the western Japanese dialect. Consequently, the g...
Satoshi Hirata, Kaname Kojima, Kazuharu Misawa, Olivier Gervais, Yosuke Kawai, Masao Nagasaki
Heliyon   4(5) e00625   May 2018   [Refereed]
Takahiro Mimori, Jun Yasuda, Yoko Kuroki, Tomoko F Shibata, Fumiki Katsuoka, Sakae Saito, Naoki Nariai, Akira Ono, Naomi Nakai-Inagaki, Kazuharu Misawa, Keiko Tateno, Yosuke Kawai, Nobuo Fuse, Atsushi Hozawa, Shinichi Kuriyama, Junichi Sugawara, Naoko Minegishi, Kichiya Suzuki, Kengo Kinoshita, Masao Nagasaki, Masayuki Yamamoto
The Pharmacogenomics Journal   19 136-146   Jan 2018   [Refereed]
Kaname Kojima, Yosuke Kawai, Kazuharu Misawa, Takahiro Mimori & Masao Nagasaki
BMC Genomics   17 991   Dec 2016   [Refereed]
Background
In the estimation of repeat numbers in a short tandem repeat (STR) region from high-throughput sequencing data, two types of strategies are mainly taken: a strategy based on counting repeat patterns included in sequence reads spanning t...
Takanori Hasegawa, Kaname Kojima, Yosuke Kawai, Kazuharu Misawa, Takahiro Mimori, Masao Nagasaki
BMC Genomics   17 745   Sep 2016   [Refereed]
Background
Genome-wide association studies have revealed associations between single-nucleotide polymorphisms (SNPs) and phenotypes such as disease symptoms and drug tolerance. To address the small sample size for rare variants, association studie...
Kazuharu Misawa
Gene Reports   4 280-285   Jan 2016   [Refereed]
Repetitive sequences in a genome cause mapping errors, especially in case of short reads, because of the presence of similar or identical sequences. Distribution of repetitive sequences in a genome must be studied to distinguish between mappable a...
Kazuharu Misawa, Ryo Ootsuki
Genomics   106 265-267   Sep 2015   [Refereed]
DNA sequencers that can conduct real-time sequencing from a single polymerase molecule are known as third-generation sequencers. Third-generation sequencers enable sequencing of reads that are several kilobases long. However, the raw data generate...
Distribution of unique sequences in the human genome
Kazuharu Misawa
Austin Journal of Computational Biology and Bioinformatics   2(1) 1010   Feb 2015   [Refereed]
Programmable sequence-specific endonucleases are powerful tools for
genome alteration with high precision. For example, the CRISPR system is an
efficient tool for genome engineering in eukaryotic cells by simply specifying a
20-bp targeting sequen...
Kazuharu Misawa
Genomics   102(1) 35-37   May 2013   [Refereed]
Next-generation sequencing platforms generate short (50-150 bp) reads that can be mapped onto the reference genome. Repetitive sequences in the genome, because of the presence of similar or identical sequences, cause mapping errors in the case of ...
Syou Kato, Kazuharu Misawa, Fumio Takahashi, Hidetoshi Sakayama, Satomi Sano, Keiko Kosuge, Fumie Kasai, Makoto M. Watanabe, Jiro Tanaka, Hisayoshi Nozaki
Journal of Phycology   47(5) 999-1008   Oct 2011   [Refereed]
Many of the genes that control photosynthesis are carried in the chloroplast. These genes differ among species. However, evidence has yet to be reported revealing the involvement of organelle genes in the initial stages of plant speciation. To elu...
Kazuharu Misawa, Reiko F. Kikuno
BMC Research Notes   4 20   May 2011   [Refereed]
Background
Codon bias is a phenomenon that refers to the differences in the frequencies of synonymous codons among different genes. In many organisms, natural selection is considered to be a cause of codon bias because codon usage in highly expres...
Kazuharu Misawa, Naoyuki Kamatani
Source Code for Biology and Medicine   6 10   May 2011   [Refereed]
Kazuharu Misawa, Reiko F. Kikuno
BioData Mining   3 6   Sep 2010   [Refereed]
Kazuharu Misawa, Naoyuki Kamatani
Source Code for Biology and Medicine   5 5   Jun 2010   [Refereed]
Shinichiro Maruyama, Motomichi Matsuzaki, Kazuharu Misawa, Hisayoshi Nozaki
BMC Evolutionary Biology   9 197   Aug 2009   [Refereed]
Kazuharu Misawa, Naoyuki Kamatani
Source Code for Biology and Medicine   4 7   May 2009   [Refereed]
Kazuharu Misawa, Reiko F. Kikuno
Gene   431(1-2) 18-22   Feb 2009   [Refereed]
Hisayoshi Nozaki, Shinichiro Maruyama, Motomichi Matsuzaki, Takashi Nakada, Syou Kato, Kazuharu Misawa
Molecular Phylogenetics and Evolution   53(3) 872-880   Dec 2009   [Refereed]
Shinichiro Maruyama, Kazuharu Misawa, Mineo Iseki, Masakatsu Watanabe, Hisayoshi Nozaki
BMC Evolutionary Biology   8 151   Aug 2008   [Refereed]
Takashi Nakada, Kazuharu Misawa, Hisayoshi Nozaki
Molecular Phylogenetic and Evolution   48(1) 281-291   Jul 2008   [Refereed]
Kazuharu Misawa, Shoogo Fujii, Toshimasa Yamazaki, Atsushi Takahashi, Junichi Takasaki, Masao Yanagisawa, Yozo Ohnishi, Yusuke Nakamura, Naoyuki Kamatani
Journal of Human Genetics   53(9) 789-801   Jul 2008   [Refereed]
Kazuharu Misawa, Naoyuki Kamatani, Reiko F. Kikuno
Journal of Molecular Evolution   67 334-342   Jul 2008   [Refereed]
Ryota Matsuo, Kazuharu Misawa. Etsuro Ito
Gene   415(1-2) 74-81   May 2008   [Refereed]
Hisayoshi Nozaki, Mineo Iseki, Masami Hasegawa, Kazuharu Misawa, Takashi Nakada, Narie Sasaki, Masakatsu Watanabe
Molecular Biology and Evolution   24(8) 1592-1595   Dec 2007   [Refereed]
Kazutaka Katoh, Kazuharu Misawa
Seibutsu Butsuri   46(6) 312-317   Dec 2006   [Invited]
Multiple sequence alignment is an important tool for computational analysis of nucleotide or amino acid sequences. It is also a challenging combinatorial optimization problem in computer science. As a large amount of sequence data is becoming avai...
Noriko Okazaki, Kazuhide Imai, Reiko F. Kikuno, Kazuharu Misawa, Makoto Kawai, Susumu Inamoto, Reiko Ohara, Takahiro Nagase, Osamu Ohara, Hisashi Koga
DNA research   12(3) 181-189   Jan 2005   [Refereed]
Kazuharu Misawa, Axel Janke
Molecular Phylogenetic and Evolution   28(2) 320-327   Aug 2003   [Refereed]
Kazuharu Misawa, Masatoshi Nei
Journal of Molecular Evolution   57 Suppl 1 S290-S296   Aug 2003   [Refereed]
Seiji Ono, Kazuharu Misawa, Kazuki Tsuji
Journal of Theoretical Biology   220 55-66   Jan 2003   [Refereed]
Kazutaka Katoh, Kazuharu Misawa, Kei-ichi Kuma, Takashi Miyata
Neucleic Acids Research   30(14) 3059-3066   Jul 2002   [Refereed]
Kazuharu Misawa, Fumio Tajima
Molecular Biology and Evolution   17(12) 1879-1884   Dec 2000   [Refereed]
Hisayoshi Nozaki, Kazuharu Misawa, Tadashi Kajita, Masahiro Kato, Seiichi Nohara, Makoto M. Watanabe
Molecular Phylogenetics and Evolution   17(2) 256-268   Nov 2000   [Refereed]
Fumio Tajima, Kazuharu Misawa, Hideki Innan
Genetica   102-103(1-6) 103-107   Oct 1998   [Refereed]
Kazuharu Misawa, Fumio Tajima
Genetics   147(4) 1959-1964   Dec 1997

Books etc

 
Estimating human point mutation rates from codon substitution rates. In: Point Mutation.
Kazuharu Misawa (Part:Contributor, 31-42)
InTech   Mar 2012   ISBN:979-953-307-447-3
http://www.intechopen.com/books/point-mutation

Conference Activities & Talks

 
Is the population of Sado Island genetically close to the population of western Japan?
Kazuharu Misawa, Hiroshi Watanabe, Akio Yokoseki, Minako Wakasugi, Osamu Onodera, Ichiei Narita, Takeshi Momotsu, Kenji Sato, Naoto Endo
Japanese Society for Human Genetics   7 Nov 2019   
Multi-allelic method for genome-wide association studies: The kernel trick
Kazuharu Misawa
ASHG 2019   18 Oct 2019   American Society of Human Genetics
Is the population of Sado Island genetically close to the population of western Japan?
Kazuharu Misawa, Hiroshi Watanabe, Akio Yokoseki, Minako Wakasugi, Osamu Onodera, Ichiei Narita, Takeshi Momotsu, Kenji Sato, Naoto Endo
24 Sep 2019   
Is the population of Sado Island genetically close to the population of western Japan?
Kazuharu Misawa
Kazuharu Misawa, Hiroshi Watanabe, Akio Yokoseki, Minako Wakasugi, Osamu Onodera, Ichiei Narita, Takeshi Momotsu, Kenji Sato, Naoto Endo   9 Aug 2019   
Urate transporters
Kazuharu Misawa, Takanori Hasegawa, Eikan Mishima, Promsuk Jutabha, Motoshi Ouchi, Kaname Kojima, Yosuke Kawai, Naohiko Anzai, and Masao Nagasaki
The 14th Meeting of Japan Transporter Research Association   20 Jul 2019   Japan Transporter Research Association
Urate transporters
Kazuharu Misawa, Eikan Mishima, Motoshi Ouchi, Takanori Hasegawa, Kaname Kojima, Yosuke Kawai, Naohiko Anzai, Masao Nagasaki, Takaaki Abe, and Masayuki Yamamoto
Transporter meeting of the northern japan   22 Dec 2018   
Rare variants explain a substantial portion of the missing heritability of the uric acid level
Kazuharu Misawa
Japanese Society of Human Genetics   11 Oct 2018   
Rare variants explain a substantial portion of the missing heritability of the uric acid level.
Kazuharu Misawa
ASHG 2018   17 Sep 2018   
Short tandem repeats in the human, cow, mouse, chicken, and lizard genomes are concentrated in the terminal regions of chromosomes
Kazuharu Misawa
SMBE2018   17 Sep 2018   
Privacy preserving Fisher's exact test for GWAS.
Kazuharu Misawa
The Japanese Society of Human Genetics (ASHG) 2017 Annual Meeting   16 Nov 2017   
Privacy preserving Fisher's exact test for GWAS.
Kazuharu Misawa
ASHG 2017   18 Oct 2017   
Privacy preserving Fisher's exact test for GWAS
Kazuharu Misawa
27 Jan 2017   
The Continuous Isolation-By-Distance Model Explains Why Genes Mirror Geography
Kazuharu Misawa
Molecular Evolution and Medicine   2017   
染色体末端のShort Tandem Repeatの進化的起源
Kazuharu Misawa
日本進化学会第19回京都大会   24 Aug 2017   
複数の研究機関が持つゲノムデータを相互に開示せず分析する解析手法を開発
Kazuharu Misawa
第2回東北メディカル・メガバンク計画合同研究会   22 Dec 2017   
Association study of rare variants on serum urate level by using whole genome cohort study samples
Kazuharu Misawa
The 2017 Japan-NIH joint Symposium   16 Feb 2017   
Association study of rare variants on serum urate level by using whole genome cohort study samples
Kazuharu Misawa
ASHG 2016   2016   
Privacy preserving Fisher's exact test for GWAS
Kazuharu Misawa
The 11th International Workshop on Security   12 Sep 2016   
PAFFT: A new homology search algorithm for third-generation sequencers
Kazuharu Misawa
The 13th International Congress of Human Genetics (ICHG2016)   Apr 2016   
Distribution of unique sequences in the human genome
Kazuharu Misawa
ASHG 2015   2015   
Haplotype関連解析の検出力のシミュレーション研究
Kazuharu Misawa
日本遺伝学会第87回大会   26 Sep 2015   
ParaHaplo: A program package for haplotype-based whole-genome association study on k computer
Kazuharu Misawa
5th AICS international symposium   8 Dec 2014   
The Continuous Isolation-By-Distance Model Explains Why Genes Mirror Geography
Kazuharu Misawa
Japanese Society for Human Genetics   21 Nov 2014   
A new algorithm for mapping next-generation sequencing data onto genome sequences of distantly-related species
Kazuharu Misawa
Japanese Society of Genetics   20 Sep 2013   
Genome wide association study on the world fastest supercomputer, the K computer.
Kazuharu Misawa, Naoyuki Kamatani
ASHG 2012   6 Nov 2012   
Genome wide association study on the world second fastest supercomputer, k computer.
Kazuharu Misawa, Naoyuki Kamatani
57th meeting of Japanese Society of Human Genetics   26 Oct 2012   
Genome wide association study on the world second fastest supercomputer, k computer.
Kazuharu Misawa, Naoyuki Kamatani
84th Meeting of Japanese Society of Genetics   26 Sep 2012   
Kazuharu Misawa, Naoyuki Kamatani
The 56th Annual Meeting of the Japan Society of Human Genetics, The 11th East Asian Union of Human Genetics (EAUHGS) Annual Meeting   Nov 2011   
Kazuharu Misawa, Naoyuki Kamatani
12th International Congress of Human Genetics   Oct 2011   
Effect of CpG mutation on codon substitution
Kazuharu Misawa
Society for Molecular Biology and Evolution   Jul 2011   
Effect of CpG mutation on codon substitution [Invited]
Kazuharu Misawa
PennState Symposium on Molecular Evolution, State College   Mar 2011   
Genome analysis by using parallel computing
Kazuharu Misawa, Naoyuki Kamatani
Japanese Society of Evolution   4 Aug 2010   
Preparation for running ParaHaplo on k computer
Kazuharu Misawa, Naoyuki Kamatani
2nd Biosupercomputing symposium   Jan 2010   
ParaHaplo: A Program Package for Haplotype-based Whole-genome Association Study using Parallel Computing
Kazuharu Misawa, Naoyuki Kamatani
Japanese Society for Human Genetics   Oct 2009   
Multiple origins of algal eyes.
Kazuharu Misawa
Japanese Society of Phycology   Mar 2009   
New correction algorithms for multiple comparisons in case-control multilocus association studies based on haplotypes and diplotype configurations.
Kazuharu Misawa, Shoogo Fujii, Toshimasa Yamazaki, Atsushi Takahashi, Junichi Takasaki, Masao Yanagisawa, Yozo Ohnishi, Yusuke Nakamura, and Naoyuki Kamatani
ASHG 2008   Oct 2008   American Society of Human Genetics
New correction algorithms for multiple comparisons in case-control multilocus association studies based on haplotypes and diplotype configurations
Kazuharu Misawa, Shoogo Fujii, Toshimasa Yamazaki, Atsushi Takahashi, Junichi Takasaki, Masao Yanagisawa, Yozo Ohnishi, Yusuke Nakamura, and Naoyuki Kamatani
Japanese Society for Human Genetics   29 Sep 2008   The Japan Society of Human Genetics
The universal trend of amino acid gain-loss is caused by CpG hypermutability.
Kazuharu Misawa
Japaneze Society for Evolution   Jul 2008   
Kazuharu Misawa
Society for Molecular Biology and Evolution   Jun 2008   
A codon substitution model that incorporates the effect of the GC contents, the gene density and the density of CpG islands of human chromosomes
Kazuharu Misawa
Japanese Society for Antholopology   7 Oct 2007   
Estimating Codon Substitution Rates between Human, Chimpanzee and Mouse
Kazuharu Misawa
Society for Molecular Biology and Evolution   May 2006   
Short tandem repeats in the human, cow, mouse, and chicken genomes are concentrated in the terminal regions of chromosomes
Kazuharu Misawa
2006   
CpG hypermutability accelerates codon substitutions in mammals
Kazuharu Misawa
2006   
Codon substitution matrix
Kazuharu Misawa
Society for Molecular Biology and Evolution   Jun 2005   
new method for reducing the false positives of gene finding
Kazuharu Misawa
Annual Meeting of the Molecular Biology Society of Japan   Dec 2003   
Estimating Codon Substitution Rates between Human, Chimpanzee and Mouse
Kazuharu Misawa
Meeting at National Institute of Genetics   Mar 2003   
Divergence times among mammalian orders
Kazuharu Misawa
Society for Molecular Biology and Evolution   Jun 2002   
Phylogenetic position of rabbits in mammalian evolution
Kazuharu Misawa
Symposium on evolutionary genomics   Nov 2001   
Phylogenetic position of rabbits in mammalian evolution
Kazuharu Misawa
Society for Molecular Biology and Evolution   Jul 2001   
Estimation of evolutionary distance by using multiple loci.
Kazuharu Misawa
International Symposim "Evolution 2000"   Mar 2000   
Phylogenetic analysis based on multilocus data
Kazuharu Misawa, Fumio Tajima
Japanese Society for Genetics   Sep 1999   
A simple method for classifying genes and a bootstrap test for classifications
Kazuharu Misawa, Fumio Tajima
Japanese Society for Genetics   Sep 1998   
Estimation of the amount of DNA polymorphism when the neutral mutation rate varies among sites
Kazuharu Misawa, Fumio Tajima
Japanese Society for Genetics   5 Oct 1996   

Research Grants & Projects

 
Japan Society for the Promotion of Science: KAKENHI
Project Year: Apr 2019 - Mar 2022    Investigator(s): Shigekazu Sugino
Japan Society for the Promotion of Science: KAKENHI
Project Year: Apr 2017 - Mar 2020    Investigator(s): Kazuharu Misawa
New correction algorithms for multiple comparisons in case-control multilocus association studies based on haplotypes and diplotype configurations