論文

査読有り
2014年1月

Interleukin 1 beta gene and risk of schizophrenia: detailed case-control and family-based studies and an updated meta-analysis

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
  • Masako Shibuya
  • ,
  • Yuichiro Watanabe
  • ,
  • Ayako Nunokawa
  • ,
  • Jun Egawa
  • ,
  • Naoshi Kaneko
  • ,
  • Hirofumi Igeta
  • ,
  • Toshiyuki Someya

29
1
開始ページ
31
終了ページ
37
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1002/hup.2365
出版者・発行元
WILEY

ObjectiveInterleukin-1 beta (IL-1) has been implicated in the pathophysiology of schizophrenia. To assess whether the IL1B gene confers increased susceptibility to schizophrenia, we conducted case-control and family-based studies and an updated meta-analysis.
MethodsWe tested the association between IL1B and schizophrenia in 1229 case-control and 112 trio samples using 12 markers, including common tagging single nucleotide variations (SNVs) and a rare non-synonymous variation detected by resequencing the coding regions. We also performed a meta-analysis of rs16944 using a total of 8724 case-control and 201 trio samples from 16 independent populations.
ResultsWe found no significant associations between any of the 12 SNVs examined and schizophrenia in either case-control or trio samples. Moreover, our meta-analysis results showed no significant association between the common SNV, rs16944, and schizophrenia.
ConclusionsThe present study does not support a role for IL1B in schizophrenia susceptibility. Copyright (c) 2013 John Wiley & Sons, Ltd.

リンク情報
DOI
https://doi.org/10.1002/hup.2365
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24155145
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000330795700006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1002/hup.2365
  • ISSN : 0885-6222
  • eISSN : 1099-1077
  • PubMed ID : 24155145
  • Web of Science ID : WOS:000330795700006

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