論文

査読有り 招待有り
2015年

Role of inflammation in Atrial fibrillation pathophysiology and management

Circulation Journal
  • Masahide Harada
  • ,
  • David R. Van Wagoner
  • ,
  • Stanley Nattel

79
3
開始ページ
495
終了ページ
502
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1253/circj.CJ-15-0138
出版者・発行元
Japanese Circulation Society

Atrial fibrillation (AF) is the most common clinically relevant arrhythmia, but the methods available for treating AF and its complications (of which the most important is thrombogenesis), as well as for assessing AF risk and underlying pathophysiology, are largely limited. Emerging evidence suggests a significant role of inflammation in the pathogenesis of AF. That evidence includes elevated serum levels of inflammatory biomarkers in AF subjects, the expression of inflammatory markers in cardiac tissues of AF patients and animal models of AF, and beneficial effects of anti-inflammatory drugs in experimental AF paradigms. Inflammation is suggested to be linked to various pathological processes, such as oxidative stress, apoptosis, and fibrosis, that promote AF substrate formation. Inflammation has also been associated with endothelial dysfunction, platelet activation, and coagulation cascade activation, leading to thrombogenesis. Thus, inflammation may contribute to both the occurrence/maintenance of AF and its thromboembolic complications. Here, we review the evidence for a role of inflammation and inflammatory biomarkers in the risk management and treatment of AF. We also summarize the current knowledge of inflammationdependent cellular and molecular mechanisms in AF pathophysiology and their potential as therapeutic targets.

リンク情報
DOI
https://doi.org/10.1253/circj.CJ-15-0138
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25746525
ID情報
  • DOI : 10.1253/circj.CJ-15-0138
  • ISSN : 1347-4820
  • ISSN : 1346-9843
  • PubMed ID : 25746525
  • SCOPUS ID : 84923465521

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