論文

査読有り
2008年9月

Trb2, a mouse homolog of tribbles, is dispensable for kidney and mouse development

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Minoru Takasato
  • ,
  • Chiyoko Kobayashi
  • ,
  • Koji Okabayashi
  • ,
  • Hiroshi Kiyonari
  • ,
  • Naoko Oshima
  • ,
  • Makoto Asashima
  • ,
  • Ryuichi Nishinakamura

373
4
開始ページ
648
終了ページ
652
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2008.06.088
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

Glomeruli comprise an important filtering apparatus in the kidney and are derived from the metanephric mesenchyme. A nuclear protein, Sall1, is expressed in this mesenchyme, and we previously reported that Trb2, a mouse homolog of Drosophila tribbles, is expressed in the mesenchyme-derived tissues of the kidney by microarray analyses using Sall1-GFP knock-in mice. In the present report, we detected Trb2 expression in a variety of organs during gestation, including the kidneys, mesonephros, testes, heart, eyes, thymus, blood vessels, muscle, bones, tongue, spinal cord, and ganglions. In the developing kidney, Trb2 signals were detected in podocytes and the prospective mesangium of the glomeruli, as well as in ureteric bud tips. However, Trb2 mutant mice did not display any apparent phenotypes and no proteinuria was observed, indicating normal glomerular functions. These results suggest that Trb2 plays minimal roles during kidney and mouse development. (c) 2008 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 10

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2008.06.088
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000258208500036&DestApp=WOS_CPL