論文

査読有り
2010年5月

Kif26b, a kinesin family gene, regulates adhesion of the embryonic kidney mesenchyme

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  • Yukako Uchiyama
  • ,
  • Masaji Sakaguchi
  • ,
  • Takeshi Terabayashi
  • ,
  • Toshiaki Inenaga
  • ,
  • Shuji Inoue
  • ,
  • Chiyoko Kobayashi
  • ,
  • Naoko Oshima
  • ,
  • Hiroshi Kiyonari
  • ,
  • Naomi Nakagata
  • ,
  • Yuya Sato
  • ,
  • Kiyotoshi Sekiguchi
  • ,
  • Hiroaki Miki
  • ,
  • Eiichi Araki
  • ,
  • Sayoko Fujimura
  • ,
  • Satomi S. Tanaka
  • ,
  • Ryuichi Nishinakamura

107
20
開始ページ
9240
終了ページ
9245
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.0913748107
出版者・発行元
NATL ACAD SCIENCES

The kidney develops through reciprocal interactions between two precursor tissues: the metanephric mesenchyme and the ureteric bud. We previously demonstrated that the zinc finger protein Sall1 is essential for ureteric bud attraction toward the mesenchyme. Here, we show that Kif26b, a kinesin family gene, is a downstream target of Sall1 and that disruption of this gene causes kidney agenesis because of impaired ureteric bud attraction. In the Kif26b-null metanephros, compact adhesion between mesenchymal cells adjacent to the ureteric buds and the polarized distribution of integrin alpha 8 were impaired, resulting in failed maintenance of Gdnf, a critical ureteric bud attractant. Overexpression of Kif26b in vitro caused increased cell adhesion through interactions with nonmuscle myosin. Thus, Kif26b is essential for kidney development because it regulates the adhesion of mesenchymal cells in contact with ureteric buds.

Web of Science ® 被引用回数 : 54

リンク情報
DOI
https://doi.org/10.1073/pnas.0913748107
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000277822600041&DestApp=WOS_CPL