2020年1月
Amphiphilic block copolymers bearing hydrophobic γ-tocopherol groups with labile acetal bond
Polymers
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- ,
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- 巻
- 12
- 号
- 1
- 開始ページ
- 36
- 終了ページ
- 36
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.3390/polym12010036
- 出版者・発行元
- {MDPI} {AG}
High concentrations of γ-tocopherol (γTCP) tend to show antioxidant, anti-inflammatory, and anticancer effects. In this study, we prepared polymer micelles under acidic conditions with a controlled release of γTCP due to the decomposition of pendant acetal bonds. First, a precursor diblock copolymer composed of poly(ethylene glycol) (PEG) and acrylic acid (AA) was prepared. This was followed by the synthesis of an amphiphilic diblock copolymer (PEG54-P(AA/VE6/γTCP29)140), incorporated into hydrophobic γTCP pendant groups attached to the main chain through an acetal bond. The prepared PEG54-P(AA/VE6/γTCP29)140 was further dispersed in water to form polymer micelles composed of hydrophobic cores that were generated from a hydrophobic block containing γTCPs and hydrophilic shells on the surface. Under acidic conditions, γTCP was then released from the core of the polymer micelles due to the decomposition of the pendant acetal bonds. In addition, polymer micelles swelled under acidic conditions due to hydration of the core.
- リンク情報
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- DOI
- https://doi.org/10.3390/polym12010036
- PubMed
- https://www.ncbi.nlm.nih.gov/pubmed/31881658
- PubMed Central
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7023524
- Web of Science
- https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000519848300036&DestApp=WOS_CPL
- URL
- https://www.mdpi.com/2073-4360/12/1/36
- Scopus Url
- http://www.scopus.com/inward/record.url?eid=2-s2.0-85078464501&partnerID=MN8TOARS
- ID情報
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- DOI : 10.3390/polym12010036
- eISSN : 2073-4360
- ORCIDのPut Code : 72637746
- PubMed ID : 31881658
- PubMed Central 記事ID : PMC7023524
- SCOPUS ID : 85078464501
- Web of Science ID : WOS:000519848300036