2012年1月
Impaired regulatory T cell reconstitution in patients with acute graft-versus-host disease and cytomegalovirus infection after allogeneic bone marrow transplantation
INTERNATIONAL JOURNAL OF HEMATOLOGY
- 巻
- 95
- 号
- 1
- 開始ページ
- 86
- 終了ページ
- 94
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1007/s12185-011-0976-7
- 出版者・発行元
- SPRINGER JAPAN KK
To elucidate the correlation between regulatory T cells (Tregs) and acute graft-versus-host disease (aGVHD) or cytomegalovirus infection following allogeneic bone marrow transplantation (allo-BMT), we evaluated either CD4(+)CD25(high) or FOXP3(+) Treg-enriched cells in peripheral blood (PB) from 20 patients who received allo-BMT, and in biopsies of skin with aGVHD. Proportions of CD4(+)CD25(high)FOXP3(+) cells in total lymphocytes, but not other types of T cells, were lower in patients who eventually developed grades II-IV aGVHD (n = 13) than in others (n = 7, P < 0.001). Proportions of CD62L(+) cells in CD4(+)CD25(high) cells at day +30 were lower (P < 0.01) in patients who eventually showed cytomegalovirus viremia (n = 6) than in others (n = 14). Incidence of aGVHD (P < 0.05) or cytomegalovirus viremia (P < 0.05) was higher in patients without these complications, but with lower proportions of PB CD4(+)CD25(high)FOXP3(+) cells at day ? 30 (n = 8) than in others (n = 8). However, in skin with aGVHD (n = 5), there was marked or slightly increased infiltration of CD8(+) cells (P < 0.001) or CD3(+)FOXP3(+) cells (P < 0.05), respectively, when compared with control (n = 5), resulting in threefold higher ratio of CD8(+)/CD3(+)FOXP3(+) cells in aGVHD relative to controls (P < 0.05). Thus, impaired reconstitution of Tregs may be associated with aGVHD and CMV infection. Moreover, imbalance of Tregs and CD8(+) cells may play a role in aGVHD tissue.
- リンク情報
- ID情報
-
- DOI : 10.1007/s12185-011-0976-7
- ISSN : 0925-5710
- eISSN : 1865-3774
- Web of Science ID : WOS:000300508800014