2018年
Inhibition of the Amyloidogenesis of Transthyretin by Natural Products and Synthetic Compounds.
Biological & pharmaceutical bulletin
- ,
- 巻
- 41
- 号
- 7
- 開始ページ
- 979
- 終了ページ
- 984
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1248/bpb.b18-00166
Hereditary transthyretin (TTR)-related amyloidosis is caused by mutations in the TTR gene. The mutations destabilize the tetramer and/or monomer of TTR, and thus the stabilization of TTR is a key strategy for the treatment of TTR-related amyloidosis. In this review, we summarized the natural products and synthetic compounds that have been shown to inhibit the amyloidogenesis of TTR. The stabilizers and/or the amyloid fibril disrupters isolated from natural sources may become lead compounds for the treatment of TTR-related amyloidosis.
- ID情報
-
- DOI : 10.1248/bpb.b18-00166
- PubMed ID : 29962408