論文

査読有り 国際誌
2013年12月20日

IQGAP1 protein regulates nuclear localization of β-catenin via importin-β5 protein in Wnt signaling.

The Journal of biological chemistry
  • Toshiyasu Goto
  • ,
  • Atsushi Sato
  • ,
  • Shungo Adachi
  • ,
  • Shun-ichiro Iemura
  • ,
  • Tohru Natsume
  • ,
  • Hiroshi Shibuya

288
51
開始ページ
36351
終了ページ
60
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1074/jbc.M113.520528

In the canonical Wnt signaling pathway, the translocation of β-catenin is important for the activation of target genes in the nucleus. However, the molecular mechanisms underlying its nuclear localization remain unclear. In the present study, we found IQGAP1 to be a regulator of β-catenin function via importin-β5. In Xenopus embryos, depletion of IQGAP1 reduced Wnt-induced nuclear accumulation of β-catenin and expression of Wnt target genes during early embryogenesis. Depletion of endogenous importin-β5 associated with IQGAP1 also reduced expression of Wnt target genes and the nuclear localization of IQGAP1 and β-catenin. Moreover, a small GTPase, Ran1, contributes to the nuclear translocation of β-catenin and the activation of Wnt target genes. These results suggest that IQGAP1 functions as a regulator of translocation of β-catenin in the canonical Wnt signaling pathway.

リンク情報
DOI
https://doi.org/10.1074/jbc.M113.520528
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/24196961
PubMed Central
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868749

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