FUKUSHIMA Tsuyoshi

J-GLOBAL         Last updated: Apr 4, 2019 at 02:40
 
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Name
FUKUSHIMA Tsuyoshi
E-mail
fukuchanmed.miyazaki-u.ac.jp
Affiliation
University of Miyazaki
Section
Faculty of Madicine School of Madicine Pathology course tumor and reproduction condition study field
Job title
Assistant Professor
Degree
Doctor of Philosophy in Medicine(University of Miyazaki)
Research funding number
10452913
ORCID ID
https://orcid.org/0000-0002-9350-777X

Research Interests

 
 

Academic & Professional Experience

 
Aug 2007
 - 
Today
Assistant Professor, Faculty of Madicine School of Madicine Pathology course tumor and reproduction condition study field, University of Miyazaki
 
Apr 2007
 - 
Jul 2007
Assistant Professor, Faculty of Madicine School of Madicine Pathology course tumor and reproduction condition study field, University of Miyazaki
 
Apr 2003
 - 
Jul 2007
Graduate student(doctorate program), Faculty of Madicine School of Madicine Pathology course tumor and reproduction condition study field, University of Miyazaki
 
Mar 2000
 - 
May 2000
Research Assistant, Faculty of Madicine School of Madicine Clinical neuroscience course neurosurgery study field, University of Miyazaki
 
Apr 1999
 - 
Feb 2000
Faculty of Madicine College Hospital Neurosurgery, University of Miyazaki
 

Education

 
 
 - 
Jul 2007
Graduate School, Division of Medical Sciences, University of Miyazaki
 
 
 - 
Mar 1996
Faculty of Medicine, Miyazaki Medical College
 

Published Papers

 
Fukushima, T., Tezuka, T., Shimomura, T., Nakano, S., Kataoka, H.
The Journal of Biological Chemistry   282(25) 18634-18644   Jun 2007   [Refereed]
Glioblastoma multiforme (GBM) is a malignant brain tumor characterized by rapid growth and extensive invasiveness. Overexpression of insulin-like growth factor-binding protein-2 (IGFBP-2) has been reported in GBM. However, it remains to be determi...
Haixia Cheng, Tsuyoshi Fukushima, Nobuyasu Takahashi, Hiroyuki Tanaka and Hiroaki Kataoka
Cancer Research   69(5) 1828-1835   Mar 2009   [Refereed]
Hepatocyte growth factor activator inhibitor-1 (HAI-1), encoded by the serine protease inhibitor Kunitz type 1 (SPINT1) gene, is a membrane-associated proteinase inhibitor that potently inhibits a variety of serine proteinases, including those tha...
Fukushima T, Kawaguchi M, Yorita K, Tanaka H, Takeshima H, Umezawa K, Kataoka H
Neuro-oncology   14(1) 19-28   Jan 2012   [Refereed]
Glioblastoma is the most malignant type of brain tumor. Despite recent advances in therapeutic modalities, the prognosis of glioblastoma remains very poor. Recent studies have indicated that RelA/nuclear factor (NF)-κB is consistently activated in...
Fukushima T, Kawaguchi M, Yamasaki M, Tanaka H, Yorita K, Kataoka H.
Cancer Science   102(2) 407-413   Feb 2011   [Refereed]
Hepatocyte growth factor activator inhibitor type 1 (HAI-1) is a transmembrane protease inhibitor that regulates the activities of membrane-bound and extracellular serine proteases. HAI-1 has two Kunitz-type inhibitor domains with the N-terminal K...
Fukushima T, Kawaguchi M, Yamamoto K, Yamashita F, Izumi A, Kaieda T, Takezaki Y, Itoh H, Takeshima H, Kataoka H
Cancer science      Jul 2018   [Refereed]
Hepatocyte growth factor activator inhibitor type 2 (HAI-2), encoded by the SPINT2 gene, is a membrane-anchored protein that inhibits proteases involved in the activation of hepatocyte growth factor (HGF), a ligand of MET receptor. Epigenetic sile...

Misc

 
Tsuyoshi Fukushima, Shuichiro Uchiyama, Hiroyuki Tanaka, Hiroaki Kataoka
International Journal of Molecular Sciences   19(11) 3435-3435   Nov 2018   [Refereed]
Hepatocyte growth factor (HGF) promotes pleiotropic signaling through its specific receptor tyrosine kinase, MET. As such, it has important roles in the regeneration of injured tissues. Since HGF is produced mainly by mesenchymal cells and MET is ...
Fukushima T.
Alkylating Agents as Environmental Carcinogen and Chemotherapy Agents   145-170   Jan 2013   [Refereed]
Nitrosoureas have been commonly used for the treatment of malignant gliomas since the 1970s. However, the prognosis of patients with malignant gliomas remains extremely poor despite the fact that multidisciplinary approaches involving surgery, che...
Fukushima T, Takeshima H, Kataoka H.
Anticancer Research   29(11) 4845-4854   Nov 2009   [Refereed]
The prognosis of patients with glioblastoma is extremely poor despite multimodal treatments including surgery, chemotherapy and radiotherapy. Recently, the alkylating agent, temozolomide (TMZ) has been shown to improve survival in patients with ma...
Tsuyoshi Fukushima, Hiroaki Kataoka
Anticancer Research   27(6A) 3685-3692   Nov 2007   [Refereed]
Insulin-like growth factor binding protein-2 (IGFBP-2) is reported to be a modulator of the action of insulin-like growth factors (IGFs), whereas IGF-independent effects of IGFBP-2 on cellular proliferation, apoptosis, and mobility have been revea...

Books etc

 
Tsuyoshi Fukushima (Part:Joint Editor, Chapter 5; Alkylatýng Agents and Treatment of Gliomas (pp. 145-171))
Nova Science Publishers, Inc.   Jul 2013   ISBN:978-1-62618-487-9
Tsuyoshi Fukushima and Hiroaki Kataoka (Part:Joint Editor, Chapter 19: Insulin-Like Growth Factor Binding Protein-2: A Possible Regulator of Invasive Growth in Glioblastoma. (pp.395-410))
InTech   Sep 2011   ISBN:978-953-307-736-9

Conference Activities & Talks

 
HAI-2/SPINT2 is epigenetically silenced in glioblastoma.
Tsuyoshi Fukushima, Makiko Kawaguchi, Koji Yamamoto, Hiroyuki Tanaka, Hiroaki Kataoka
The 36th Annual Meeting of Japan Human Cell Society   4 Aug 2018   Japan Human Cell Society
(Aim) Promoter methylation status of a DNA repair gene, MGMT, is known as one of the most important prognostic factors of patients with glioblastoma treated with an alkylating agent. There may be many genes whose expression are epigenetically regu...
Expression of long non-coding RNAs in glioblastoma and roles of MALAT1 in invasion
Fukushima T and Kataoke H
The 27th Meeting of the Japanese Association for Metastasis Research   19 Jul 2018   The Japanese Association for Metastasis Research
Glioblastoma is the most malignant brain tumor characterized by rapid growth, extensive invasiveness, and angiogenesis. Understanding of the molecular mechanism of the malignant features and breakthrough in the treatment are required. Some cancers...
Clinicopathological findings of five cases of diffuse midline glioma, H3 K27M-mutant
Tsuyoshi Fukushima, Mitsuru Tamura, Tomohiro Kawano, Shinji Yamashita, Kiyotaka Yokogami, Hideo Takeshima, Yutaka Akiyama3, Hiroyuki Tanaka, and Hiroaki Kataoka
The 107th Annual Meeting of the Japanese Society of Pathology   21 Jun 2018   The Japanese Society of Pathology
Diffuse midline glioma, H3 K27M-mutant (DMG) is a newly defined grade IV glioma in the revised WHO classification (2016). This tumor accompanies mutation in histone family 3 variant 3 (H3.3; encoded by H3F3A) or variant 1 (H3.1; encoded by HIST1H3...
Roles of a long non-coding RNA, MALAT-1, in pancreatic ductal adenocarcinoma cells
Tsuyoshi Fukushima, Makiko Kawaguchi, Koji Yamamoto, Hiroyuki Tanaka, Takeshi Shimomura, and Hiroaki Kataoka
2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会)   6 Dec 2017   日本分子生物学会、日本生化学会
Expressions of long non-coding RNAs (lncRNAs) have been reported in various malignancies; however, the physiological and pathological functions have been still unclear. MALAT-1 was originally identified as a lncRNA which is highly expressed in non...
Expression of long non-coding RNAs in glioblastoma
The 35th Annual Meeting of Japanese Human Cell Society   7 Oct 2017   Japanese Human Cell Society
Long non-coding RNAs (lncRNAs) have been implicated in malignant features of various cancers. Expressions of several lncRNAs have been reported in glioblastoma, the most malignant brain tumor. Which non-coding RNAs are expressed and how they are i...

Research Grants & Projects

 
Multifaceted approach for understanding of malignant phenotype of glioblastoma
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2017 - Today    Investigator(s): Tsuyoshi Fukushima
Exploratory analysis for functional genes which regulate the malignant features of glioblastoma
Japan Society for the Promotion of Science: Grants-in-Aid for Scientific Research
Project Year: Apr 2008 - Mar 2010