論文

国際誌
2021年10月16日

High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study.

Modern rheumatology
  • Yayoi Hashiba
  • ,
  • Kunihiko Umekita
  • ,
  • Masatoshi Kimura
  • ,
  • Chihiro Iwao
  • ,
  • Kosho Iwao
  • ,
  • Yumi Kariya
  • ,
  • Kazuyoshi Kubo
  • ,
  • Shunichi Miyauchi
  • ,
  • Risa Kudou
  • ,
  • Yuki Rikitake
  • ,
  • Takeshi Kawaguchi
  • ,
  • Motohiro Matsuda
  • ,
  • Ichiro Takajo
  • ,
  • Eisuke Inoue
  • ,
  • Toshihiko Hidaka
  • ,
  • Akihiko Okayama

記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1093/mr/roab077

OBJECTIVES: We aimed to assess the clinical features of human T-cell leukaemia virus type 1 (HTLV-1)-positive rheumatoid arthritis (RA) patients. Furthermore, we investigated the impact of HTLV-1 infection on incidences of serious infections requiring hospitalisation (SIH) and malignancies. METHODS: A total of 150 sex- and age-matched HTLV-1-negative and 50 HTLV-1-positive RA patients were enrolled from the HTLV-1 RA Miyazaki Cohort Study. Clinical and laboratory data were collected from this cohort database. The incidence rate (IR) for SIH and malignancies from 2015 to 2020 was analysed. RESULTS: The median age and female ratio in the study population were 70 years old and 80%, respectively. Although no differences were found in inflammatory marker values between the two groups, the patient global assessment and Health Assessment Questionnaire scores were higher in HTLV-1-positive RA patients. In HTLV-1-negative RA patients, the IR for SIH was 6.37/100 person-years (PY) and 1.32/100 PY for malignancies. In HTLV-1-positive RA patients, SIH occurred in 11.1/100 PY and malignancies in 2.46/100 PY. The crude IR ratio comparing SIH between two groups was 1.74 (95% confidence interval, 1.04-2.84), which was a significant increase. CONCLUSIONS: HTLV-1-positive RA patients may worsen RA symptoms. HTLV-1 may be a risk factor for SIH.

リンク情報
DOI
https://doi.org/10.1093/mr/roab077
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/34897491
ID情報
  • DOI : 10.1093/mr/roab077
  • PubMed ID : 34897491

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