MISC

2007年9月

Mei4p coordinates the onset of meiosis I by regulating cdc25(+) in fission yeast

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
  • Yuko Murakami-Tonami
  • ,
  • Chisato Yamada-Namikawa
  • ,
  • Akiko Tochigi
  • ,
  • Norio Hasegawa
  • ,
  • Hisae Kojima
  • ,
  • Mitoshi Kunimatsu
  • ,
  • Makoto Nakanishi
  • ,
  • Hiroshi Murakami

104
37
開始ページ
14688
終了ページ
14693
記述言語
英語
掲載種別
DOI
10.1073/pnas.0702906104
出版者・発行元
NATL ACAD SCIENCES

The kinase Cdc2p is a central regulator of entry into and progression through nuclear division during mitosis and meiosis in eukaryotes. Cdc2p is activated at the onset of mitosis by dephosphorylation on tyrosine-15, the phosphorylation status of which is determined mainly by the kinase Wee1p and the phosphatase Cdc25p. In fission yeast, the forkhead-type transcription factor Mei4p is required for expression of many genes during meiosis, with mei4 mutant cells arresting before meiosis 1. The mechanism of cell cycle arrest in mei4 cells has remained unknown, however. We now show that cdc25(+) is an important target of Mei4p in control of entry into meiosis 1. Forced dephosphorylation of Cdc2p on tyrosine-15 thus induced meiosis 1 in mei4 mutant cells without a delay, although no spores were formed. We propose that Mei4p acts as a rate-limiting regulator of meiosis I by activating cdc25+ transcription in coordination with other meiotic events.

Web of Science ® 被引用回数 : 14

リンク情報
DOI
https://doi.org/10.1073/pnas.0702906104
CiNii Articles
http://ci.nii.ac.jp/naid/80018220486
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/17804800
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000249513000027&DestApp=WOS_CPL

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