MISC

2009年10月

Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeast

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Midori Shimada
  • ,
  • Ayumu Yamamoto
  • ,
  • Yuko Murakami-Tonami
  • ,
  • Makoto Nakanishi
  • ,
  • Takashi Yoshida
  • ,
  • Hirofumi Aiba
  • ,
  • Hiroshi Murakami

388
3
開始ページ
529
終了ページ
532
記述言語
英語
掲載種別
DOI
10.1016/j.bbrc.2009.08.030
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

The spindle checkpoint is a surveillance mechanism that ensures the fidelity of chromosome segregation in mitosis. Here we show that fission yeast casein kinase II (CK2) is required for this checkpoint function. In the CK2 mutants mitosis occurs in the presence of a spindle defect, and the spindle checkpoint protein Mad2p fails to localize to unattached kinetochores. The CK2 mutants are sensitive to the microtubule depolymerising drug thiabendazole, which is counteracted by ectopic expression of mad2(+). The level of Mad2p is low in the CK2 mutants. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p. (C) 2009 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 4

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2009.08.030
CiNii Articles
http://ci.nii.ac.jp/naid/80020523906
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/19666000
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000275061900012&DestApp=WOS_CPL

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