論文

査読有り
2016年8月

SGO1 is involved in the DNA damage response in MYCN-amplified neuroblastoma cells

SCIENTIFIC REPORTS
  • Yuko Murakami-Tonami
  • ,
  • Haruna Ikeda
  • ,
  • Ryota Yamagishi
  • ,
  • Mao Inayoshi
  • ,
  • Shiho Inagaki
  • ,
  • Satoshi Kishida
  • ,
  • Yosuke Komata
  • ,
  • Jan Koster
  • ,
  • Ichiro Takeuchi
  • ,
  • Yutaka Kondo
  • ,
  • Tohru Maeda
  • ,
  • Yoshitaka Sekido
  • ,
  • Hiroshi Murakami
  • ,
  • Kenji Kadomatsu

6
開始ページ
31615
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1038/srep31615
出版者・発行元
NATURE PUBLISHING GROUP

Shugoshin 1 (SGO1) is required for accurate chromosome segregation during mitosis and meiosis; however, its other functions, especially at interphase, are not clearly understood. Here, we found that downregulation of SGO1 caused a synergistic phenotype in cells overexpressing MYCN. Downregulation of SGO1 impaired proliferation and induced DNA damage followed by a senescence-like phenotype only in MYCN-overexpressing neuroblastoma cells. In these cells, SGO1 knockdown induced DNA damage, even during interphase, and this effect was independent of cohesin. Furthermore, MYCN-promoted SGO1 transcription and SGO1 expression tended to be higher in MYCN- or MYC-overexpressing cancers. Together, these findings indicate that SGO1 plays a role in the DNA damage response in interphase. Therefore, we propose that SGO1 represents a potential molecular target for treatment of MYCN-amplified neuroblastoma.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1038/srep31615
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/27539729
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000381666300001&DestApp=WOS_CPL

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