論文

査読有り
2017年10月

A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP(1-1))

CHEMICAL COMMUNICATIONS
  • Yuko Shishido
  • ,
  • Fumiaki Tomoike
  • ,
  • Yasuaki Kimura
  • ,
  • Keiko Kuwata
  • ,
  • Takato Yano
  • ,
  • Kenji Fukui
  • ,
  • Haruka Fujikawa
  • ,
  • Yoshitaka Sekido
  • ,
  • Yuko Murakami-Tonami
  • ,
  • Tomoshi Kameda
  • ,
  • Satoshi Shuto
  • ,
  • Hiroshi Abe

53
81
開始ページ
11138
終了ページ
11141
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1039/c7cc05829b
出版者・発行元
ROYAL SOC CHEMISTRY

We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP1-1 function. LC-MS/MS and X-ray structure analyses of the covalently linked GST-inhibitor complex suggested that 1 reacted with Tyr108 of GSTP1-1. The mechanism of covalent bond formation was discussed based on MD simulation results.

Web of Science ® 被引用回数 : 14

リンク情報
DOI
https://doi.org/10.1039/c7cc05829b
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28848941
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000412760500007&DestApp=WOS_CPL

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