2021年10月25日
Hurdles for the wide implementation of photoimmunotherapy
Immunotherapy
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- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.2217/imt-2021-0241
- 出版者・発行元
- Future Medicine Ltd
Near infrared photoimmunotherapy (NIR-PIT) is a molecularly targeted treatment for cancers achieved by injecting a conjugate of IRDye700DX® (IR700), a water-soluble silicon phthalocyanine derivative in the near infrared, and a monoclonal antibody that targets cancer cell antigens. NIR-PIT is a highly specific treatment with few side effects that results in rapid immunogenic cell death. Despite it being a very effective and innovative therapy, there are a few challenges preventing full implementation in clinical practice. These include the limits of near infrared light penetration, selection of targets, concerns about tumor lysis syndrome and drug costs. However, NIR-PIT has been approved by the regulatory authorities in Japan, allowing for exploration of how to mitigate challenges while maximizing the benefits of this treatment modality.
- ID情報
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- DOI : 10.2217/imt-2021-0241
- ISSN : 1750-743X
- eISSN : 1750-7448