NAGASE Hiroki

J-GLOBAL         Last updated: Jun 24, 2019 at 17:47
 
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Name
NAGASE Hiroki
E-mail
hnagasechiba-cc.jp
Section
Research Institute
Job title
Director
Degree
MD PhD(Kumamoto Univ.)

Research Areas

 

Published Papers

 
NAGASE Hiroki
Journal of Open Source Software   4(37) 1423   May 2019   [Refereed]
Estimating genome-wide off-target effects for pyrrole-imidazole polyamide binding by a pathway-based expression profiling approach.
NAGASE Hiroki
PLoS One   14(4) e0215247   Apr 2019   [Refereed]
Direct Targeting of MYCN Gene Amplification by Site-Specific DNA Alkylation in Neuroblastoma
NAGASE Hiroki
Cancer Research   79(4) 830-840   Feb 2019   [Refereed]
Suppression of GPR56 expression by pyrrole-imidazole polyamide represents a novel therapeutic drug for AML with high EVI1 expression
NAGASE Hiroki
Scientific Reports   8(1) 13741   Sep 2018   [Refereed]
Hydrophobic structure of hairpin ten-ring pyrrole-imidazole polyamides enhanced tumor tissue accumulation/retention in vivo
NAGASE Hiroki
Bioorganic & Medicinal Chemistry   26(9) 2337-2344   May 2018   [Refereed]

Conference Activities & Talks

 
Sequence-specific alkylating pyrrole-imidazole polyamide conjugates targeting multiple immune checkpoints
NAGASE Hiroki
11th AACR-JCA Joint Conference on Breakthroughs in Cancer Research   10 Feb 2019   
Sequence-specific minor groove binders for the diagnosis and treatment of cancer: Application in mutant DNA enrichment for liquid biopsy, fluorescent probes and genome DNA targeted therapy [Invited]
NAGASE Hiroki
University of Hawaii Cancer Center Thoracic Oncology Seminar   9 Feb 2019   
Chem-seq: Evaluation of Genomewide Binding Effects of DNA Minor Groove-Binding Pyrrole Imidazole Polyamides
Jason Lin
RECOMB/ISCB Conference on Regulatory and Systems Genomics with DREAM Challenges 2018   10 Dec 2018   
Development of a novel therapeutic strategy targeting high copy number amplification of oncogenes in neuroblastoma
TAKATORI Atsushi
50th Congress of the “Société Internationale d’Oncologie Pédiatrique” (SIOP) 2018   18 Nov 2018   
Suppression of MYCN and DNA repair enhances cellular cytotoxicity in neuroblastoma
NAGASE Hiroki
10 Nov 2018   
DNA alkylating pyrrole-imidazole (PI) polyamide inhibits the expression of immunity checkpoint molecules
NANKINZAN Rino
8 Nov 2018   
Epigenetic modification by using PI polyamide drug conjugates [Invited]
NAGASE Hiroki
The5th International Canser Epigenomics Symposium 2018   8 Nov 2018   
Site-directed DNA damage of the amplified MYCN gene promotes neuroblastoma cell death
NAGASE Hiroki
29 Sep 2018   
Targeting the RAS Gene Against Cancer
NAGASE Hiroki
The 6th JCA-AACR Special Joint Conference   11 Jul 2018   
Targeting mutant PIK3CA dependent cervical cancer by Pyrrole Imidazole polyamide seco-CBI conjugate
Krishnamurthy Sakthisri
31 May 2018