SASAKI Tsutomu

J-GLOBAL         Last updated: Aug 28, 2019 at 21:41
 
Avatar
Name
SASAKI Tsutomu
Affiliation
Kyoto University
Section
Graduate School of Agriculture Division of Food Science and Biotechnology
Job title
Associate Professor
Degree
Doctor of Philosophy (Ph.D.)(University of Virginia)
ORCID ID
0000-0001-8041-1915

Research Areas

 
 

Academic & Professional Experience

 
Apr 2013
   
 
Associate Professor, Gunma University 
 

Education

 
 
 - 
2007
Neuroscience, Neuroscience Graduate Program, University of Virginia
 

Awards & Honors

 
2002
Crutchfield, Gage and Thomson Award
 
2013
JES Young Investigator Award
 

Published Papers

 
Tsutomu Sasaki, Rika Numano, Hiromi Yokota-Hashimoto, Sho Matsui, Naobumi Kimura, Hideyuki Takeuchi, Tadahiro Kitamura
Molecular Brain   11(1) 28   May 2018   [Refereed]
Matsui S, Sasaki T*, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T.
Nature Communications      Nov 2018   [Refereed]
Takayoshi Suga, Osamu Kikuchi, Masaki Kobayashi, Sho Matsui, Hiromi Yokota-Hashimoto, Eri Wada, Daisuke Kohno, Tsutomu Sasaki, Kazusane Takeuchi, Satoru Kakizaki, Masanobu Yamada, Tadahiro Kitamura
Molecular Metabolism   19 1-12   Jan 2019   [Refereed]
Fukunaka, Ayako; Fukada, Toshiyuki; Bhin, Jinhyuk; Suzuki, Luka; Tsuzuki, Takamasa; Takamine, Yuri; Bin, Bum-Ho; Yoshihara, Toshinori; Ichinoseki-Sekine, Noriko; Naito, Hisashi; Miyatsuka, Takeshi; Takamiya, Shinzaburo; Sasaki, Tsutomu; Inagaki, Takeshi; Kitamura, Tadahiro; Kajimura, Shingo; Watada, Hirotaka; Fujitani, Yoshio
PLOS GENETICS   13(8) e1006950   2017
Ishimaru, Yoshiro; Kozuka, Chisayo; Nakajima, Kenichiro; Sasaki, Tsutomu
JOURNAL OF PHYSIOLOGICAL SCIENCES   67(1) 83-95   2017
Sasaki, Tsutomu; Matsui, Sho; Kitamura, Tadahiro
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   17(7) 1081   2016
Sasaki, Tsutomu; Kuroko, Mitsutaka; Sekine, Sawako; Matsui, Sho; Kikuchi, Osamu; Susanti, Vina Yanti; Kobayashi, Masaki; Tanaka, Yoshinori; Yuasa, Tomoyuki; Kitamura, Tadahiro
ENDOCRINE JOURNAL   62(9) 787-796   2015
Sasaki, Tsutomu; Kinoshita, Yoshihiro; Matsui, Sho; Kakuta, Shigeru; Yokota-Hashimoto, Hiromi; Kinoshita, Kuni; Iwasaki, Yusaku; Kinoshita, Toshio; Yada, Toshihiko; Amano, Naoji; Kitamura, Tadahiro
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY   309(5) R561-R575   2015
Kohno, Daisuke; Lee, Syann; Harper, Matthew J.; Kim, Ki Woo; Sone, Hideyuki; Sasaki, Tsutomu; Kitamura, Tadahiro; Fan, Guoping; Elmquist, Joel K.
JOURNAL OF NEUROSCIENCE   34(46) 15288-15296   2014
Susanti, Vina Yanti; Sasaki, Tsutomu; Yokota-Hashimoto, Hiromi; Matsui, Sho; Lee, Yong-Soo; Kikuchi, Osamu; Shimpuku, Mayumi; Kim, Hye-Jin; Kobayashi, Masaki; Kitamura, Tadahiro
OBESITY   22(10) 2115-2119   2014
Yoshino, Satoshi; Satoh, Tetsurou; Yamada, Masanobu; Hashimoto, Koshi; Tomaru, Takuya; Katano-Toki, Akiko; Kakizaki, Satoru; Okada, Shuichi; Shimizu, Hiroyuki; Ozawa, Atsushi; Tuchiya, Takafumi; Ikota, Hayato; Nakazato, Yoichi; Mori, Munemasa; Matozaki, Takashi; Sasaki, Tsutomu; Kitamura, Tadahiro; Mori, Masatomo
ENDOCRINOLOGY   155(9) 3459-3472   2014
Sasaki, Tsutomu; Kikuchi, Osamu; Shimpuku, Mayumi; Susanti, Vina Yanti; Yokota-Hashimoto, Hiromi; Taguchi, Ryo; Shibusawa, Nobuyuki; Sato, Takashi; Tang, Lijun; Amano, Kosuke; Kitazumi, Tomoya; Kuroko, Mitsutaka; Fujita, Yuki; Maruyama, Jun; Lee, Yong-soo; Kobayashi, Masaki; Nakagawa, Takashi; Minokoshi, Yasuhiko; Harada, Akihiro; Yamada, Masanobu; Kitamura, Tadahiro
DIABETOLOGIA   57(4) 819-831   2014
Lee, Yong-Soo; Kobayashi, Masaki; Kikuchi, Osamu; Sasaki, Tsutomu; Yokota-Hashimoto, Hiromi; Susanti, Vina Yanti; Kitamura, Yukari Ido; Kitamura, Tadahiro
ENDOCRINE JOURNAL   61(1) 85-90   2014
Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates
Sasaki, Tsutomu; Shimpuku, Mayumi; Kitazumi, Tomoya; Hiraga, Haruna; Nakagawa, Yuko; Shibata, Hiroshi; Okamatsu-Ogura, Yuko; Kikuchi, Osamu; Kim, Hye-jin; Fujita, Yuki; Maruyama, Jun; Susanti, Vina Yanti; Yokota-Hashimoto, Hiromi; Kobayashi, Masaki; Saito, Masayuki; Kitamura, Tadahiro
ENDOCRINE JOURNAL   60(10) 1117-1129   2013
Syamsunarno, Mas Rizky A. A.; Iso, Tatsuya; Hanaoka, Hirofumi; Yamaguchi, Aiko; Obokata, Masaru; Koitabashi, Norimichi; Goto, Kosaku; Hishiki, Takako; Nagahata, Yoshiko; Matsui, Hiroki; Sano, Motoaki; Kobayashi, Masaki; Kikuchi, Osamu; Sasaki, Tsutomu; Maeda, Kazuhisa; Murakami, Masami; Kitamura, Tadahiro; Suematsu, Makoto; Tsushima, Yoshito; Endo, Keigo; Hotamisligil, Goekhan S.; Kurabayashi, Masahiko
PLOS ONE   8(11) e79386   2013
Lee, Y. -S.; Sasaki, T.; Kobayashi, M.; Kikuchi, O.; Kim, H. -J.; Yokota-Hashimoto, H.; Shimpuku, M.; Susanti, V. -Y.; Ido-Kitamura, Y.; Kimura, K.; Inoue, H.; Tanaka-Okamoto, M.; Ishizaki, H.; Miyoshi, J.; Ohya, S.; Tanaka, Y.; Kitajima, S.; Kitamura, T.
DIABETOLOGIA   56(6) 1383-1393   2013
Masubuchi, Yosuke; Nakagawa, Yuko; Ma, Jinhui; Sasaki, Tsutomu; Kitamura, Tadahiro; Yamamoto, Yoritsuna; Kurose, Hitoshi; Kojima, Itaru; Shibata, Hiroshi
PLOS ONE   8(1) e54500   2013
Hepatic FoxO1 integrates glucose utilization and lipid synthesis through regulation of Chrebp O-glycosylation.
Ido-Kitamura Y, Sasaki T, Kobayashi M, Kim HJ, Lee YS, Kikuchi O, Yokota-Hashimoto H, Iizuka K, Accili D, Kitamura T.
PLoS One   7(10) e47231   2012
Overexpression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance.
Kim HJ, Kobayashi M, Sasaki T, Kikuchi O, Amano K, Kitazumi T, Lee YS, Yokota-Hashimoto H, Susanti VY, Kitamura YI, Nakae J, Kitamura T
Endocrinology      2012
FoxO1 as a Double-edged Sword in the Pancreas: Analysis of Pancreas and β Cell-specific FoxO1 Knockout Mice.
Kobayashi M, Kikuchi O, Sasaki T, Kim HJ, Yokota-Hashimoto H, Lee YS, Amano K, Kitazumi T, Susanti VY, Kitamura YI, Kitamura T
Am J Physiol Endocrinol Metab      2012
FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization.
Kikuchi O, Kobayashi M, Amano K, Sasaki T, Kitazumi T, Kim HJ, Lee YS, Yokota-Hashimoto H, Kitamura YI, Kitamura T
PLoS One   7(2) e32249   2012
Necdin controls foxo1 acetylation in hypothalamic arcuate neurons to modulate the thyroid axis.
Hasegawa K, Kawahara T, Fujiwara K, Shimpuku M, Sasaki T, Kitamura T, Yoshikawa K.
Journal of Neuroscience   32(16) 5562-72   2012
Genetic Defect in Phospholipase C{delta}1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis.
Hirata M, Suzuki M, Ishii R, Satow R, Uchida T, Kitazumi T, Sasaki T, Kitamura T, Yamaguchi H, Nakamura Y, Fukami K.
Diabetes   60(7) 1926-37   2011
Roles of FoxO1 and Sirt1 in the central regulation of food intake.
Sasaki T, Kitamura T.
Endocrine Journal   57(11) 939-46   2010
Induction of hypothalamic Sirt1 leads to cessation of feeding via agouti-related peptide.
Sasaki T, Kim HJ, Kobayashi M, Kitamura YI, Yokota-Hashimoto H, Shiuchi T, Minokoshi Y, Kitamura T.
Endocrinology   151(6) 2556-66   2010
Regulation of pancreatic juxtaductal endocrine cell formation by FoxO1.
Kitamura T, Kitamura YI, Kobayashi M, Kikuchi O, Sasaki T, Depinho RA, Accili D.
Molecular and Cellular Biology   Epub ahead of print    2009
Phosphorylation regulates SIRT1 function.
Sasaki T, Maier B, Koclega KD, Chruszcz M, Gluba W, Stukenberg PT, Minor W, Scrable H.
PLoS One   3 e4020   2008
Identification of the deleted in liver cancer 1 gene, DLC1, as a candidate meningioma tumor suppressor.
Hankins GR, Sasaki T, Lieu AS, Saulle D, Karimi K, Li JZ, Helm GA.
Neurosurgery   63 771-80   2008
Progressive loss of SIRT1 with cell cycle withdrawal.
Sasaki T, Maier B, Bartke A, Scrable H.
Aging Cell   5 413-422   2006
DeltaNp53 or p44: priming the p53 pump.
Scrable H, Sasaki T, Maier B. DeltaNp53 or p44: priming the p53 pump. (Int J Biochem Cell Biol, 37: 913-919, 2005)
international journal of biochemistry & cell biology   37 913-919   2005
Comparison of gene expression profiles between frozen original meningiomas and primary cultures of the meningiomas by GeneChip.
Sasaki T, Hankins GR, Helm GA.
Neurosurgery   52 892-899   2003
Osteogenic potential of five different recombinant human bone morphogenetic protein (BMP) vectors in rats.
Li JZ, Li H, Sasaki T, Holman D, Beres B, Dumont RJ, Pittman DD, Hankins GR, Helm GA.
Gene Therapy   10 1735-1743   2003
Major Vault Protein/Lung resistance-related protein (MVP/LRP) expression in nervous system tumors.
Sasaki T, Hankins GR, Helm GA.
Brain Tumor Pathology   19 59-62   2002
Ectopic Osteogenesis Using Adenoviral Bone Morphogenetic Protein (BMP)-4 and BMP-6 Gene Transfer.
Jane JA Jr, Dunford BA, Kron A, Pittman DD, Sasaki T, Li JZ, Li H, Alden TD, Dayoub H, Hankins GR, Kallmes DF, Helm GA.
Molecular Therapy   6 464-470   2002
Expression of survivin, inhibitor of apoptosis protein, in tumors of the nervous system.
Sasaki T, Lopes MBS, Hankins GR, Helm GA.
Acta Neuropathologica (Berlin)   104 105-109   2002
Cavernous angioma of the internal acoustic meatus--case report.
Sasaki T, Sasaki T, Okamoto K, Ishida T, Kirino T.
Neurologia-medico chirurgica (Tokyo)   39 847-851   1999
Iwakoshi-Ukena, Eiko; Shikano, Kenshiro; Kondo, Kunihiro; Taniuchi, Shusuke; Furumitsu, Megumi; Ochi, Yuta; Sasaki, Tsutomu; Okamoto, Shiki; Bentley, George E.; Kriegsfeld, Lance J.; Minokoshi, Yasuhiko; Ukena, Kazuyoshi
ELIFE   6 e28527   2017   [Refereed]
Sasaki, Tsutomu; Hiraga, Haruna; Yokota-Hashimoto, Hiromi; Kitamura, Tadahiro
ENDOCRINE JOURNAL   62(5) 469-473   2015   [Refereed]
Sasaki, Tsutomu; Yasoshima, Yasunobu; Matsui, Sho; Yokota-Hashimoto, Hiromi; Kobayashi, Masaki; Kitamura, Tadahiro
APPETITE   118 120-128   2017   [Refereed]
Usui, Taro; Kajita, Kazuo; Kajita, Toshiko; Mori, Ichiro; Hanamoto, Takayuki; Ikeda, Takahide; Okada, Hideyuki; Taguchi, Koichiro; Kitada, Yoshihiko; Morita, Hiroyuki; Sasaki, Tsutomu; Kitamura, Tadahiro; Sato, Takashi; Kojima, Itaru; Ishizuka, Tatsuo
FEBS LETTERS   588(10) 1935-1941   2014   [Refereed]

Research Grants & Projects

 
Role of hypothalamic Sirt1 in the regulation of energy metabolism.
Grant-in-Aid for Scientific Research
Project Year: 2007