2006年5月
Gene and protein expression profiles of prostaglandin E2 receptor subtypes in the human corpus cavernosum
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
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- 巻
- 18
- 号
- 3
- 開始ページ
- 275
- 終了ページ
- 281
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1038/sj.ijir.3901408
- 出版者・発行元
- NATURE PUBLISHING GROUP
Prostaglandin E1 leads to penile erection, mainly via prostaglandin E2 (EP) receptors. This study aimed to identify the expression profile of EP receptor genes in human corpus cavernosum. Using the quantitative real-time reverse transcription polymerase chain reaction, the mRNA levels of EP receptor subtypes were measured. In addition, expressions of EP receptor subtype proteins were determined by immunohistochemical method. Among the four subtypes, EP4 receptor mRNA expression was the highest, and EP2 receptor mRNA followed, whereas EP1 and EP3 receptor mRNAs were hardly observed. Expression level of EP4 receptor mRNA was significantly higher than that of EP2 receptor mRNA. Expression of both EP2 and EP4 receptor proteins were clearly detected in the cavernous smooth muscle. These results may suggest that EP4 receptor plays an important role among four EP receptor subtypes for relaxation of smooth muscle in the human corpus cavernosum.
- リンク情報
- ID情報
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- DOI : 10.1038/sj.ijir.3901408
- ISSN : 0955-9930
- Web of Science ID : WOS:000237222100007