2017年
Responsiveness of Coronary Arteries to Nitroglycerin under Hypoxia: The Importance of the Endothelium
Pharmacology
- ,
- ,
- ,
- 巻
- 99
- 号
- 5-6
- 開始ページ
- 275
- 終了ページ
- 280
- 記述言語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1159/000461587
- 出版者・発行元
- S. Karger AG
Background/Aims: Nitroglycerin is widely used as a coronary vasodilator in the treatment of ischemic heart diseases. This study investigated the influence of hypoxia on nitroglycerin-induced relaxation in endothelium-intact and -denuded rabbit, monkey, and porcine coronary arteries. Methods: Helically cut strips of coronary arteries were suspended in organ chambers, and isometric tension was recorded. Results: Nitroglycerin concentration dependently relaxed endothelium-intact rabbit coronary arteries, which were not different under normoxic and hypoxic conditions. On the other hand, nitroglycerin-induced relaxation of endothelium-denuded arteries was significantly attenuated by hypoxia. Similarly, the relaxant response of endothelium-intact monkey coronary arteries to nitroglycerin was not affected by hypoxia, whereas that of endothelium-denuded arteries was impaired. As is the case with rabbit and monkey coronary arteries, exposure to hypoxia resulted in impaired relaxation by nitroglycerin in endothelium-denuded but not endothelium-intact porcine coronary arteries. Conclusion: These findings suggest that coronary endothelium plays a pivotal role in preventing the hypoxia-induced impairment of nitroglycerin responsiveness, regardless of the animal species.
- リンク情報
- ID情報
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- DOI : 10.1159/000461587
- ISSN : 0031-7012
- eISSN : 1423-0313
- Web of Science ID : WOS:000398945900009