Min-Jue Xie

Profile Information

Affiliation: Assistant Professor, Faculty of Advanced ResearchesResearch Center for Child Mental Development Research Center for Child Mental Development, University of Fukui

Researcher number: 40444210
J-GLOBAL ID: 200901077253787121
researchmap Member ID: 6000018302

Research Interests

Research Areas

Life sciences / Neuroanatomy and physiology /

Research History

Dec, 2021 - Present

Assistant Professor, Faculty of Advanced ResearchesResearch Center for Child Mental Development Research Center for Child Mental Development, University of Fukui
Jul, 2015 - Present

助教, 福井大学子どものこころの発達研究センター
Oct, 2020 - Oct, 2021

United Graduate School of Child Development, Osaka University, Kanazawa University,Hamamatsu University School of Medicine,Chiba University and University of Fukui Research Center for Children's Mental Development, Osaka University
Apr, 2008 - Jun, 2015

- 福井大学医学部, 助教
2006 - 2008

COE 研究員, 福井大学医学部
2008

助教, 福井大学医学部
2004 - 2006

研究員, 独立行政法人科学技術振興機構事業
2001 - 2003

博士研究員, フランス国立健康医学研究所（INSERM）
1990 - 1996

内科医員, 中国上海第二医科大学付属仁済病院

Education

Apr, 1997 - Mar, 2001

Kanazawa University
Sep, 1984 - Jul, 1990

医学科, その他
- 1990

医学科, 医学部, 中国上海第二医科大学

Committee Memberships

Papers

Phldb2 is essential for regulating hippocampal dendritic spine morphology through drebrin in an adult-type isoform-specific manner

Min-Jue Xie, Hideshi Yagi, Tokuichi Iguchi, Hiroyuki Yamazaki, Kenji Hanamura, Hideo Matsuzaki, Tomoaki Shirao, Makoto Sato

Neuroscience Research, 185 1-10, Sep, 2022
Measurement of Mitochondrial Respiration in Cryopreserved Human Peripheral Blood Mononuclear Cells (PBMCs)

Keiko Iwata, Min-Jue Xie, Paul C. Guest, Takaharu Hirai, Hideo Matsuzazki

Multiplex Biomarker Techniques, 321-332, 2022
Mutually Repulsive EphA7-EfnA5 Organize Region-to-Region Corticopontine Projection by Inhibiting Collateral Extension.

Tokuichi Iguchi, Yuichiro Oka, Misato Yasumura, Minoru Omi, Kazuki Kuroda, Hideshi Yagi, Min-Jue Xie, Manabu Taniguchi, Martin Bastmeyer, Makoto Sato

The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(22) 4795-4808, Jun 2, 2021
Autistic-Like Behavior and Impairment of Serotonin Transporter and AMPA Receptor Trafficking in N-Ethylmaleimide Sensitive Factor Gene-Deficient Mice.

Min-Jue Xie, Keiko Iwata, Yasuyuki Ishikawa, Yuki Nomura, Tomomi Tani, Koshi Murata, Yugo Fukazawa, Hideo Matsuzaki

Frontiers in genetics, 12 748627-748627, 2021
Increased plasma lipoprotein lipase activity in males with autism spectrum disorder

Takaharu Hirai, Noriyoshi Usui, Keiko Iwata, Taishi Miyachi, Kenji J. Tsuchiya, Min-Jue Xie, Kazuhiko Nakamura, Masatsugu Tsujii, Toshiro Sugiyama, Hideo Matsuzaki

Research in Autism Spectrum Disorders, 77 101630-101630, Sep, 2020 Peer-reviewed
Autism-related deficits via dysregulated NSF-dependent membrane protein trafficking.

Xie MJ, Iwata K, Ishikawa Y, Fukazawa Y, Matsuzaki H.

J. Neurochem., 150(SI) 206-207, Jul, 2019 Peer-reviewed
PIP₃-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.

Xie MJ, Ishikawa Y, Yagi H, Iguchi T, Oka Y, Kuroda K, Iwata K, Kiyonari H, Matsuda S, Matsuzaki H …

Sci Rep., 9(1) 4305, Mar, 2019 Peer-reviewed
Subcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70

Hideshi Yagi, Tetsuji Takabayashi, Min-Jue Xie, Kazuki Kuroda, Makoto Sato

PLOS ONE, 12(2) e0172257, Feb, 2017 Peer-reviewed
Effects of Buyang Huanwu decoction combined with edaravone on mitochondrial apoptotic pathway of nerve cells in mice with cerebral ischemia-reperfusion injury

Fang-Fang Zhong, Cheng-Long Wu, Yan-Xing Zhang, Xin-Fang Sun, Min-Jue Xie, Makoto Sato

INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 10(4) 6749-6755, 2017 Peer-reviewed
Filamin A interacting protein plays a role in proper positioning of callosal projection neurons in the cortex

Hideshi Yagi, Yuichiro Oka, Munekazu Komada, Min-Jue Xie, Koichi Noguchi, Makoto Sato

NEUROSCIENCE LETTERS, 612 18-24, Jan, 2016 Peer-reviewed
FILIP関連分子はNMDA受容体と結合し、海馬ニューロンにおける棘突起成熟とシナプス機能を制御する(FILIP-related molecule binds to NMDA receptor and controls spine maturation and synaptic function in the hippocampal neuron)

Kuroda Kazuki, Yagi Hideshi, Xie Minjue, Omi Minoru, Iguchi Tokuichi, Oka Yuichiro, Sato Makoto

The Journal of Physiological Sciences, 65(Suppl.1) S124-S124, Mar, 2015
DBZ Regulates Cortical Cell Positioning and Neurite Development by Sustaining the Anterograde Transport of Lis1 and DISC1 through Control of Ndel1 Dual-Phosphorylation

Masayuki Okamoto, Tokuichi Iguchi, Tsuyoshi Hattori, Shinsuke Matsuzaki, Yoshihisa Koyama, Manabu Taniguchi, Munekazu Komada, Min-Jue Xie, Hideshi Yagi, Shoko Shimizu …

JOURNAL OF NEUROSCIENCE, 35(7) 2942-2958, Feb, 2015 Peer-reviewed
Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation

Hideshi Yagi, Takashi Nagano, Min-Jue Xie, Hiroshi Ikeda, Kazuki Kuroda, Munekazu Komada, Tokuichi Iguchi, Rahman M. Tariqur, Soichi Morikubo, Koichi Noguchi …

SCIENTIFIC REPORTS, 4 6353, Sep, 2014 Peer-reviewed
Anxiety- and depression-like behavior in mice lacking the CD157/BST1 gene, a risk factor for Parkinson's disease

Olga Lopatina, Toru Yoshihara, Tomoko Nishimura, Jing Zhong, Shirin Akther, Azam A. K. M. Fakhrul, Mingkun Liang, Chiharu Higashida, Kohei Sumi, Kazumi Furuhara …

FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 8 133, Apr, 2014 Peer-reviewed
WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration

Min-Jue Xie, Hideshi Yagi, Kazuki Kuroda, Chen-Chi Wang, Munekazu Komada, Hong Zhao, Akira Sakakibara, Takaki Miyata, Koh-Ichi Nagata, Yuichiro Oka …

Cerebral Cortex, 23(6) 1410-1423, Jun, 2013 Peer-reviewed
The roles of Hedgehog signaling during the proliferation/differentiation of intermediate progenitor cells

Munekazu Komada, Tokuichi Iguchi, Kazuki Kuroda, Min-jue Xie, Hideshi Yagi, Makoto Sato

NEUROSCIENCE RESEARCH, 71 E229-E229, 2011 Peer-reviewed
Dendritic growth cone activity to resume radial migration properly in the course of multipolar-bipolar transition

Min-Jue Xie, Hideshi Yagi, Kazuki Kuroda, Munekazu Komada, Tokuichi Iguchi, Makoto Sato

NEUROSCIENCE RESEARCH, 71 E129-E129, 2011 Peer-reviewed
Regulation of dendritic spine morphology by FILIP

Hideshi Yagi, Min-Jue Xie, Hiroshi Ikeda, Munekazu Komada, Tokuichi Iguchi, Kazuki Kuroda, Masaru Okabe, Makoto Sato

NEUROSCIENCE RESEARCH, 71 E344-E345, 2011 Peer-reviewed
LL5 beta Directs the Translocation of Filamin A and SHIP2 to Sites of Phosphatidylinositol 3,4,5-Triphosphate (PtdIns(3,4,5)P-3) Accumulation, and PtdIns(3,4,5)P-3 Localization Is Mutually Modified by Co-recruited SHIP2

Tetsuji Takabayashi, Min-Jue Xie, Seiji Takeuchi, Motomi Kawasaki, Hideshi Yagi, Masayuki Okamoto, Rahman M. Tariqur, Fawzia Malik, Kazuki Kuroda, Chikara Kubota …

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(21) 16155-16165, May, 2010 Peer-reviewed
LL5 beta regulates morphology and maturation of dendritic spines

Xie MinJue, Iguchi Tokuichi, Yagi Hideshi, Shirao Tomoaki, Sato Makoto

NEUROSCIENCE RESEARCH, 68 E231-E232, 2010 Peer-reviewed

Misc.

DBZはNdel1のリン酸化修飾制御を通して軸索伸長および皮質神経細胞の配置に関与する

猪口徳一, 猪口徳一, 岡本昌之, 岡本昌之, 服部剛志, 服部剛志, 松崎伸介, 松崎伸介, 駒田致和, 謝敏カク …

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 121st 98, 2016 Peer-reviewedInvited
DISC1-binding zinc finger protein (DBZ) regulates cortical cell positioning and neurite elongation through control of Ndel1 dual-phosphorylation

Iguchi T, Okamoto M, Hattori T, Matsuzaki S, Koyama Y, Taniguchi M, Komada M, Xie M, Yagi H, Shimizu S …

Neuroscience 2015, SfN's 45th annual meeting, Oct, 2015 Peer-reviewed
神経細胞のスパインにおけるFILIP関連分子の生体における機能解析

黒田一樹, 黒田一樹, 謝敏カク, 謝敏カク, 謝敏カク, 尾身実, 尾身実, 八木秀司, 八木秀司, 佐藤真 …

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 119th, 2014
神経細胞の棘突起(スパイン)におけるFILIP関連分子の機能解析

黒田一樹, 謝敏カク, 猪口徳一, 岡雄一郎, 尾身実, 王振吉, 王振吉, 八木秀司, 佐藤真

日本解剖学会総会・全国学術集会講演プログラム・抄録集, 118th 163, 2013
大脳皮質形成と棘突起形態に対するFILIPの役割(Filip play a role in cortical development and spine morphology)

八木秀司, 謝敏カク, 池田弘, 駒田致和, 猪口徳一, 黒田一樹, 岡部勝, 佐藤真

神経化学, 50(2-3) 191-191, Sep, 2011
誘導型遺伝子発現系を利用した神経回路形成におけるアミロイド前駆体タンパク質の機能解析(Molecular analysis of amyloid beta precursor protein on the neuronal network formation using in utero electroporation gene transfer combined with inducible gene expression system)

猪口徳一, 黒田一樹, 謝敏カク, 八木秀司, 佐藤真

神経化学, 49(2-3) 709-709, Aug, 2010
胎仔期神経発生におけるアクチン線維の可視化

八木秀司, 謝敏カク, 猪口徳一, 黒田一樹, 佐藤真

解剖学雑誌, 85(Supplement) 189-189, Mar, 2010
大脳皮質形成関連因子の神経回路形成における機能解析~トランスポゾンによる染色体遺伝子導入と遺伝子発現誘導系を用いたアプローチ~

猪口徳一, 黒田一樹, 謝敏カク, 八木秀司, 佐藤真

解剖学雑誌, 85(Supplement) 137-137, Mar, 2010
Deletion of FILIP leaded to the abnormal responses in the visual cortex

Hideshi Yagi, Hiroshi Ikeda, Nobuyuki Yamasaki, Tsuyoshi Miyakawa, Masaru Okabe, Min-Jue Xie, Makoto Sato

NEUROSCIENCE RESEARCH, 61 S233-S233, 2008
Sulfolobus tokodaii由来組換えフラップエンドヌクレアーゼの発現と活性

堀江祐範, 杉森賢司, 福井孝一, 謝敏カク, 崎濱由梨, 景山義隆, 橋野仁一, 松本和子, 松本和子

日本農芸化学会大会講演要旨集, 2006, 2006
Expressions of pancreatitis-associated protein and cytokines correlate with apoptosis in spontaneous chronic pancreatitis in the WBN/Kob rat

SU SHI-BING, MOTOO YOSHIHARU, XIE MIN-JUE, MOURI HISATSUGU, SAWABU NORIO

26(4) 399-400, May 1, 2003
WBN/Kobラットの慢性膵炎に対する柴胡桂枝湯の抗線維化作用 (漢方を科学する特集:柴胡桂枝湯のメカニズム)

元雄良治, 蘇式兵, 謝敏〔カク〕

漢方医学, 26(3) 116-119, Jul, 2002
Expression of pancreatitis-associated protein (PAP) and cytokines in relation to apoptosis in spontaneous chronic pancreatitis in the WBN/Kob rat

SU Shi-Bing, MOTOO Yoshiharu, XIE Min-Jue, MOURI Hisatsugu, SAWABU Norio

16(4) 373-380, Aug 28, 2001
P8 gene expression is induced in the acinar cells during chronic pancreatitis.

Y Motoo, N Sawabu, MJ Xie, SB Su, GV Mallo, JL Iovanna

GASTROENTEROLOGY, 118(4) A428-A428, Apr, 2000

Presentations

Schizophrenia-like behavior in the D1R-specifi c NSF defi cient mice.

Xie MJ, Murata K, Matsuzaki H.

Neurossience2023, Nov 12, 2023
Phldb2 regulates hippocampal dendritic spine morphology.

Xie MJ, Sato M.

第64回日本神経病理学会総会学術研究会/第66回日本神経化学会大会合同大会, Jul 6, 2023
The D1R-specific NSFdeficient mice as a novel schizophrenic model.

Xie MJ, Murata K, Matsuzaki H.

17th Meeting of the Asian-Pacific Society for Neurochemistry, Jun 19, 2023
NSF deficient mice leads to autism like behavior with hippocampal synaptic dysfunction．

Xie MJ, Iwata K, Ishikawa Y, Fukazawa Y, Matsuzaki H.

第64回日本神経化学会大会, Sep 30, 2021
Abnormal social interaction in NSF knockout and SERT expressing neuron-specific NSF knockout mice.

Xie MJ.

第43回日本神経科学大会, Jul 31, 2020
神経細胞のスパインにおけるFILIP関連分子の生体における機能解析

第119回日本解剖学会・全国学術集会, 2014
Phldb2はLTD誘導後のシナプスでのAMPA受容体のエンドサイトーシスを制御する

第36回日本生物学的精神医学会、第57回日本神経化学会大会, 2014
Phldb2は樹状突起スパインの成熟および可塑性を制御する

第37回日本神経科学大会, 2014
脂質関連分子はLTD誘導後のシナプスでのAMPA受容体のエンドサイトーシスを制御する

第41回日本脳科学会, 2014
Phldb2はLTD誘導後のシナプスでのAMPA受容体のエンドサイトーシスを制御する

第36回日本生物学的精神医学会、第57回日本神経化学会大会, 2014
神経細胞の棘状突起（スパイン）形成におけるFILIP関連分子の機能解析

第118回日本解剖学会・全国学術集会, 2013
Phldb2は樹状突起スパインの成熟および化学的LTD誘導後のシナプスでのAMPA受容体のエンドサイトーシスを制御する

Neuro2013, 2013
FILIP関連分子によるMyosin-Ⅱbを介した神経細胞野ｽﾊﾟｲﾝ形成の制御とシナプス可塑性における機能解析

Neuro2013, 2013
Phldb2はAMPA受容体のエンドサイトーシスおよびLTDを制御する

第14回ORIGIN神経科学研究会夏のワークショップ, 2013
Phld2 regulates the maturation of dendritic spines and AMPA receptor endocytosis during long-term depression.

Society For Neuroscience 2013, 2013
FILIP-related molecule controls spine maturation and synaptic function in the hippocampal neuron via non-muscle myosin Ⅱb.

Society For Neuroscience 2013, 2013
Phldb2 regulates the maturation of dendritic spines and AMPA receptor endcytosis under chemical long-term depression

Neuro2013, 2013
Phld2 regulates the maturation of dendritic spines and AMPA receptor endocytosis during long-term depression.

Society For Neuroscience 2013, 2013
皮質脊髄路の発達における軸策側枝形成因子の探索

第117回日本解剖学会・全国学術集会, 2012
神経細胞の棘状突起（スパイン）形成におけるFILIP関連分子の機能解析

第117回日本解剖学会・全国学術集会, 2012

Professional Memberships

Works

Research Projects

Glutathione system in the brain of children with autism spectrum disorder

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2027
Exploring the role of mitochondrial biogenesis in oligodendrocyte differentiation and animal behaviors in vitro and in vivo: involvement in schizophrenia

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2023 - Mar, 2026
ドーパミン受容体の異常に着目した新たな統合失調症モデルの確立

科学研究費助成事業, 基盤研究(C), 日本学術振興会, Apr, 2021 - Mar, 2024

謝敏カク, 松崎秀夫, 村田航志
The synaptic insufficient delivery hypothesis of autism based on PET findings

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2019 - Mar, 2022

Matsuzaki Hideo
Elucidation of the BDNF-lipid-related Phldb2 for regulation of synaptic plasticity

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2018 - Mar, 2021

Xie Min Jue
The synaptic insufficient delivery hypothesis of autism based on PET findings

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2016 - Mar, 2019

Matsuzaki Hideo
Study on a new synaptic accumulation mechanism of AMPA receptor by lipid-related molecules

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

XIE MINJUE
Analysis of novel actin filament binding protein on the synaptic biology and autism.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2014 - Mar, 2016

Kuroda Kazuki, Sato Makoto, Yagi Hideshi, Xie Min-Jue
Significance of novel non-muscle myosin-binding partners in the brain

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Sato Makoto, OKA Yuichiro, XIE Min-Jie, IGUCHI Tokuichi, KURODA Kazuki, OMI Minoru
Possible roles of microglia and the underlying mechanisms on the brain development

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2015

SATO Makoto, XIE Min-Jue, OMI Minoru, IGUCHI Tokuichi
Analysis of the control mechanism of Neuronal migration by new stratagem.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Challenging Exploratory Research, Japan Society for the Promotion of Science, Apr, 2012 - Mar, 2014

KURODA Kazuki, SATO Makoto, XIE Min-jue, IGUCHI Tokuichi
Study on a regulatory mechanism of the maturation of dendritic spines and the synaptic plasticity by lipid-related molecules

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2011 - 2013

XIE Min-Jue, SATO Makoto, KURODA Kazuki, IGUCHI Tokuichi, KOMADA Munekazu
Studies on how cytoskeleton-related molecules regulate neuronal migration, the brain formation as well as the maturation.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2009 - 2011

SATO Makoto, YAGI Hideshi, XIE Min-jue, IGUCHI Tokuichi, IKEDA Hiroshi
Studies on novel mechanism of proteins that relate to migration and proliferation of neuronal cells

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2008 - 2010

YAGI Hideshi, XIE MinーJue, SATO Makoto
大脳皮質内神経回路操作法の樹立と神経細胞移動障害による大脳回路機能変異の解明

科学研究費助成事業, 挑戦的萌芽研究, 日本学術振興会, 2008 - 2009

佐藤真, 謝敏カク
Studies on how actins and microtubules are coordinated and its relevancy.

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (B), Japan Society for the Promotion of Science, 2007 - 2008

SATO Makoto, IKEDA Hiroshi, YAGI Hideshi, XIE Min-jue, TAKEUCHI Seiji
Elucidation for the unidentified role and the neurological etiology in XPA

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, 2007 - 2008

TAKEUCHI Seiji
シナプスの形成、成熟および可塑性に関する研究
Study on the formation, maturation and plasticity of synapse.

Profile Information

Research Interests

Research Areas

Research History

Education

Committee Memberships

Papers

Misc.

Presentations

Professional Memberships

Works

Research Projects

Menu

Coauthors