論文

査読有り
2012年2月

Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer

CLINICAL BIOCHEMISTRY
  • Takeshi Ishikawa
  • Satoshi Kokura
  • Naoyuki Sakamoto
  • Manabu Okajima
  • Tatsuzo Matsuyama
  • Hiromi Sakai
  • Yoko Okumura
  • Satoko Adachi
  • Naohisa Yoshida
  • Kazuhiko Uchiyama
  • Osamu Handa
  • Tomohisa Takagi
  • Hideyuki Konishi
  • Naoki Wakabayashi
  • Nobuaki Yagi
  • Takashi Ando
  • Kazuko Uno
  • Yuji Naito
  • Toshikazu Yoshikawa
  • 全て表示

45
3
開始ページ
207
終了ページ
211
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.clinbiochem.2011.09.007
出版者・発行元
PERGAMON-ELSEVIER SCIENCE LTD

Objective: To investigate the relation between functional impairments of cancer patients and circulating cytokines using a multiplex technique.
Design and methods: 50 patients with cancer were assessed using the quality of life (QOL) questionnaire. 27 plasma cytokine levels were determined by using the Bio-Plex array system. The relation to QOL scores was assessed using Chi-square test for categorical variables and univariate linear regression analysis for cytokine levels.
Results: Multivariate analysis showed that interleukin-6 (IL-6) level is a significant independent determinant of physical (beta=-0.238, P=0.0126) and cognitive functioning (beta=-0.462, P=0.0006) and that vascular endothelial growth factor (VEGF) level is a significant independent determinant of emotional functioning (beta=-0.414, P=0.039).
Conclusion: This study, in which 27 cytokines are simultaneously tested with cutting edge technology, demonstrates that plasma IL-6 and VEGF are significant independent determinants of functional impairments in patients with cancer. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.clinbiochem.2011.09.007
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/21963382
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000300120100006&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.clinbiochem.2011.09.007
  • ISSN : 0009-9120
  • PubMed ID : 21963382
  • Web of Science ID : WOS:000300120100006

エクスポート
BibTeX RIS