2012年2月
Relationship between circulating cytokine levels and physical or psychological functioning in patients with advanced cancer
CLINICAL BIOCHEMISTRY
- 巻
- 45
- 号
- 3
- 開始ページ
- 207
- 終了ページ
- 211
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.clinbiochem.2011.09.007
- 出版者・発行元
- PERGAMON-ELSEVIER SCIENCE LTD
Objective: To investigate the relation between functional impairments of cancer patients and circulating cytokines using a multiplex technique.
Design and methods: 50 patients with cancer were assessed using the quality of life (QOL) questionnaire. 27 plasma cytokine levels were determined by using the Bio-Plex array system. The relation to QOL scores was assessed using Chi-square test for categorical variables and univariate linear regression analysis for cytokine levels.
Results: Multivariate analysis showed that interleukin-6 (IL-6) level is a significant independent determinant of physical (beta=-0.238, P=0.0126) and cognitive functioning (beta=-0.462, P=0.0006) and that vascular endothelial growth factor (VEGF) level is a significant independent determinant of emotional functioning (beta=-0.414, P=0.039).
Conclusion: This study, in which 27 cytokines are simultaneously tested with cutting edge technology, demonstrates that plasma IL-6 and VEGF are significant independent determinants of functional impairments in patients with cancer. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Design and methods: 50 patients with cancer were assessed using the quality of life (QOL) questionnaire. 27 plasma cytokine levels were determined by using the Bio-Plex array system. The relation to QOL scores was assessed using Chi-square test for categorical variables and univariate linear regression analysis for cytokine levels.
Results: Multivariate analysis showed that interleukin-6 (IL-6) level is a significant independent determinant of physical (beta=-0.238, P=0.0126) and cognitive functioning (beta=-0.462, P=0.0006) and that vascular endothelial growth factor (VEGF) level is a significant independent determinant of emotional functioning (beta=-0.414, P=0.039).
Conclusion: This study, in which 27 cytokines are simultaneously tested with cutting edge technology, demonstrates that plasma IL-6 and VEGF are significant independent determinants of functional impairments in patients with cancer. (C) 2011 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.clinbiochem.2011.09.007
- ISSN : 0009-9120
- PubMed ID : 21963382
- Web of Science ID : WOS:000300120100006