MISC

2006年7月

Progesterone receptor antagonist is effective in relieving neuropathic pain

EUROPEAN JOURNAL OF PHARMACOLOGY
  • Daisuke Kondo
  • ,
  • Ritsuko Yabe
  • ,
  • Takashi Kurihara
  • ,
  • Hironao Saegusa
  • ,
  • Shuqin Zong
  • ,
  • Tsutomu Tanabe

541
1-2
開始ページ
44
終了ページ
48
記述言語
英語
掲載種別
DOI
10.1016/j.ejphar.2006.05.010
出版者・発行元
ELSEVIER SCIENCE BV

Injury to the spinal nerves of mice induces allodynia and hyperalgesia. Intrathecal injection of the progesterone/estrogen receptor antagonist ICI 182,780 produced antinociceptive effects. Co-administration of estrogen did not reduce but tended to enhance the antinociceptive effect of ICI 182,780. On the other hand, co-administration of progesterone dose-dependently reduced the antimociceptive effect of ICI 182,780, indicating that the antinociceptive effect is through antiprogesterone receptor activity of ICI 182,780. These results suggest that spinal progesterone receptors play an important role in neuropathic pain, and that controlling the activity of progesterone receptors may be of great importance in the treatment of neuropathic pain. (c) 2006 Elsevier B.V All rights reserved.

Web of Science ® 被引用回数 : 19

リンク情報
DOI
https://doi.org/10.1016/j.ejphar.2006.05.010
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000238803700007&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.ejphar.2006.05.010
  • ISSN : 0014-2999
  • Web of Science ID : WOS:000238803700007

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