論文

査読有り
2019年11月

Distinct effects of orexin receptor antagonist and GABA agonist on sleep and physical/cognitive functions after forced awakening

Proceedings of the National Academy of Sciences of the United States of America
  • Seol, Jaehoon
  • ,
  • Fujii, Yuya
  • ,
  • Park, Insung
  • ,
  • Suzuki, Yoko
  • ,
  • Kawana, Fusae
  • ,
  • Yajima, Katsuhiko
  • ,
  • Fukusumi, Shoji
  • ,
  • Okura, Tomohiro
  • ,
  • Satoh, Makoto
  • ,
  • Tokuyama, Kumpei
  • ,
  • Kokubo, Toshio
  • ,
  • Yanagisawa, Masashi

116
48
開始ページ
24353
終了ページ
24358
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1073/pnas.1907354116
出版者・発行元
NATL ACAD SCIENCES

The majority of patients with insomnia are treated with hypnotic agents. In the present study, we evaluated the side-effect profile of an orexin receptor antagonist and γ-aminobutyric acid A (GABA) receptor agonist on physical/cognitive functions upon forced awakening. This double-blind, randomized, placebo-controlled, cross-over study was conducted on 30 healthy male subjects. Fifteen minutes before bedtime, the subjects took a pill of suvorexant (20 mg), brotizolam (0.25 mg), or placebo and were forced awake 90 min thereafter. Physical- and cognitive-function tests were performed before taking the pill, after forced awakening, and the next morning. Polysomnographic recordings revealed that the efficacies of the hypnotic agents in prolonging total sleep time (∼30 min) and increasing sleep efficiency (∼6%) were comparable. When the subjects were allowed to go back to sleep after the forced awakening, the sleep latency was shorter under the influence of hypnotic agents (∼2 min) compared to the placebo trial (24 min), and the rapid eye movement latency was significantly shorter under suvorexant (98.8, 81.7, and 48.8 min for placebo, brotizolam, and suvorexant, respectively). A

リンク情報
DOI
https://doi.org/10.1073/pnas.1907354116

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