SHIBATA Atsushi

J-GLOBAL         Last updated: Nov 6, 2019 at 10:46
 
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Name
SHIBATA Atsushi
URL
http://shibatalab.com/english/
Affiliation
Gunma University
Section
Gunma University Initiative for Advanced Research (GIAR)
Job title
Associate Professor (PI)
Degree
Medicine(Tokyo Medical and Dental University)
ORCID ID
0000-0001-8912-6977

Profile

The Shibata Laboratory

Our laboratory aims to elucidate the molecular mechanism underlying DNA double-strand break (DSB) repair, which is critical for maintaining genome integrity. Defects in DSB repair lead to severe mutations, including deletions and chromosomal translocations, which cause cell death. Introducing such severe mutations is important for killing cancer cells via radio/chemotherapy. In addition, DSB repair and signaling is involved in many biological events such as tumorigenesis, immunity, protection against virus, and biological development.
  We are currently investigating the interplay between non-homologous end joining (NHEJ) and homologous recombination (HR), which are major DSB repair pathways. We have recently attempted to visualize a repair event at a single DSB using super-resolution microscope 3D structured-illumination microscopy (SIM). We have also conducted several ongoing projects with radiation oncologists on combined radio- and immunotherapy.

Research Areas

 
 

Academic & Professional Experience

 
Apr 2019
 - 
Today
群馬大学
 
Apr 2017
 - 
Mar 2019
Education and Research Support Center (ERSC), Graduate School of Medicine, Gunma University 
 
2012
 - 
2013
JSPS postdoctoral fellowship for Research Abroad, University of Sussex
 
2006
 - 
2012
Postdoctoral fellow, University of Sussex
 
2006
 - 
2007
Medical and Dental Sciences Postdoctoral Degree (Ph.D, medicine), Tokyo Medical and Dental University
 
2004
 - 
2006
Japan Society for the Promotion of Science, Fellowship DC1, Tokyo Medical and Dental University
 

Education

 
 
 - 
2006
Tokyo Medical and Dental University
 
 
 - 
2003
Degree of Pharmaceutical Master, Kyoritsu College of Pharmacy
 
 
 - 
2001
Bachelor of Pharmacy, Faculty of medicine Department, Kyoritsu College of Pharmacy
 

Awards & Honors

 
2012
Poster prize, Joint British Association for Cancer Research-Gray Institute
 
2010
Highly rated poster presentations, The AACR 101st Annual Meeting
 

Published Papers

 
Sangeeta Kakoti, Motohiro Yamauchi, Wenchao Gu, Reona Kato, Takaaki Yasuhara, Yoshihiko Hagiwara, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*, *Corresponding author.
Oncology Reports      2019   [Refereed]
Hiro Sato, Penny A. Jeggo and Atsushi Shibata*, Sangeeta Kakoti, Motohiro Yamauchi, Wenchao Gu, Reona Kato, Takaaki Yasuhara, Yoshihiko Hagiwara, Siddhartha Laskar, Takahiro Oike, Hiro Sato, Kathryn D. Held, Takashi Nakano and Atsushi Shibata*, *Corresponding author.
Cancer Science      2019   [Refereed]
Narisa Dewi Maulany Darwis, Ankita Nachankar, Yasushi Sasaki, Toshiaki Matsui, Shin-ei Noda, Kazutoshi Murata, Tomoaki Tamaki, Ken Ando, Noriyuki Okonogi, Shintaro Shiba, Daisuke Irie, Takuya Kaminuma, Takuya Kumazawa, Mai Anakura, Souichi Yamashita, Takashi Hirakawa, Sangeeta Kakoti, Yuka Hirota, Takashi Tokino, Akira Iwase, Tatsuya Ohno, Atsushi Shibata, Takahiro Oike and Takashi Nakano
International Journal of Molecular Sciences   20(18) 4563   2019   [Refereed]
Toshiaki Matsui, Endang Nuryadi, Shuichiro Komatsu, Yuka Hirota, Atsushi Shibata, Takahiro Oike and Takashi Nakano
International Journal of Molecular Sciences   20(17) 4148   2019   [Refereed]
Shuichiro Komatsu, Takahiro Oike, Yuka Komatsu, Yoshiki Kubota, Makoto Sakai, Toshiaki Matsui, Endang Nuryadi, Tiara Bunga Mayang Permata, Hiro Sato, Hidemasa Kawamura, Masahiko Okamoto, Takuya Kaminuma, Kazutoshi Murata, Naoko Okano, Yuka Hirota, Tatsuya Ohno, Jun-ichi Saitoh, Atsushi Shibata and Takashi Nakano
Radiotherapy & Oncology   139 87-93   2019   [Refereed]
Mai Anakura, Ankita Nachankar, Daijiro Kobayashi, Napapat Amornwichet, Yuka Hirota, Atsushi Shibata, Takahiro Oike and Takashi Nakano.
International Journal of Molecular Sciences   20(15) 3635   2019   [Refereed]
Elucidation of the Mechanism Regulating Transcription Associated DNA Double Strand Break Repair and Its Pathway.
Atsushi Shibata & Takaaki Yasuhara
Impact   3 50-52   2019
Shibata A, Jeggo P, Löbrich M
DNA repair      Aug 2018   [Refereed]
Nuryadi E, Sasaki Y, Hagiwara Y, Permata TBM, Sato H, Komatsu S, Yoshimoto Y, Murata K, Ando K, Kubo N, Okonogi N, Takakusagi Y, Adachi A, Iwanaga M, Tsuchida K, Tamaki T, Noda SE, Hirota Y, Shibata A, Ohno T, Tokino T, Oike T, Nakano T
Oncotarget   9(66) 32642-32652   Aug 2018   [Refereed]
Hagiwara Y, Niimi A, Isono M, Yamauchi M, Yasuhara T, Limsirichaikul S, Oike T, Sato H, Held KD, Nakano T, Shibata A
Oncotarget   8(65) 109370-109381   Dec 2017   [Refereed]
Sato H, Niimi A, Yasuhara T, Permata TBM, Hagiwara Y, Isono M, Nuryadi E, Sekine R, Oike T, Kakoti S, Yoshimoto Y, Held KD, Suzuki Y, Kono K, Miyagawa K, Nakano T, Shibata A
Nature Communications   8(1) 1751   Nov 2017   [Refereed]
Shibata A
Mutation Research   803-805 51-55   Oct 2017   [Refereed]
Sakasai R, Isono M, Wakasugi M, Hashimoto M, Sunatani Y, Matsui T, Shibata A, Matsunaga T, Iwabuchi K
Scientific Reports   7(1) 13808   Oct 2017   [Refereed]
Kobayashi D, Shibata A, Oike T, Nakano T
Journal of visualized experiments : JoVE   (128)    Oct 2017   [Refereed]
Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA
Molecular cell   53(1) 7-18   Jan 2014   [Refereed]
Nakajima NI, Niimi A, Isono M, Oike T, Sato H, Nakano T, Shibata A
Oncology Reports   38(2) 693-702   Aug 2017   [Refereed]
Atsushi Shibata, Penny Jeggo
Clin Oncol (R Coll Radiol)      2014
Kakarougkas A, Ismail A, Katsuki Y, Freire R, Shibata A, Jeggo PA
Nucleic acids research   41(22) 10298-10311   Dec 2013   [Refereed]
Biehs R, Steinlage M, Barton O, Juhász S, Künzel J, Spies J, Shibata A, Jeggo PA, Löbrich M
Molecular Cell   65(4) 671-684.e5   Feb 2017   [Refereed]
Kakarougkas A, Ismail A, Klement K, Goodarzi AA, Conrad S, Freire R, Shibata A, Lobrich M, Jeggo PA
Nucleic acids research   41(21) 9719-9731   Nov 2013   [Refereed]
Yamauchi M, Shibata A, Suzuki K, Suzuki M, Niimi A, Kondo H, Miura M, Hirakawa M, Tsujita K, Yamashita S, Matsuda N
Scientific Reports   7 41812   Feb 2017   [Refereed]
Nakajima NI, Brunton H, Watanabe R, Shrikhande A, Hirayama R, Matsufuji N, Fujimori A, Murakami T, Okayasu R, Jeggo P, Shibata A
PloS one   8(8) e70107   2013   [Refereed]
Isono M, Niimi A, Oike T, Hagiwara Y, Sato H, Sekine R, Yoshida Y, Isobe SY, Obuse C, Nishi R, Petricci E, Nakada S, Nakano T, Shibata A
Cell Reports   18(2) 520-532   Jan 2017   [Refereed]
Kobayashi D, Oike T, Shibata A, Niimi A, Kubota Y, Sakai M, Amornwhichet N, Yoshimoto Y, Hagiwara Y, Kimura Y, Hirota Y, Sato H, Isono M, Yoshida Y, Kohno T, Ohno T, Nakano T
Scientific Reports   7 40588   Jan 2017   [Refereed]
Niimi A, Yamauchi M, Limsirichaikul S, Sekine R, Oike T, Sato H, Suzuki K, Held KD, Nakano T, Shibata A
Genes, Chromosomes & Cancer   55(8) 650-660   Aug 2016   [Refereed]
Oike T, Niimi A, Okonogi N, Murata K, Matsumura A, Noda SE, Kobayashi D, Iwanaga M, Tsuchida K, Kanai T, Ohno T, Shibata A, Nakano T
Scientific Reports   6 22275   Mar 2016   [Refereed]
Tookman LA, Browne AK, Connell CM, Bridge G, Ingemarsdotter CK, Dowson S, Shibata A, Lockley M, Martin SA, McNeish IA
Molecular Cancer Research   14(1) 44-55   Jan 2016   [Refereed]
Isono M, Yoshida Y, Takahashi A, Oike T, Shibata A, Kubota Y, Kanai T, Ohno T, Nakano T
Journal of radiation research   56(5) 856-861   Sep 2015   [Refereed]
Alagoz M, Katsuki Y, Ogiwara H, Ogi T, Shibata A, Kakarougkas A, Jeggo P
Nucleic acids research   43(16) 7931-7944   Sep 2015   [Refereed]
Amornwichet N, Oike T, Shibata A, Nirodi CS, Ogiwara H, Makino H, Kimura Y, Hirota Y, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T
Scientific reports   5 11305   Jun 2015   [Refereed]
Nakajima NI, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, Shibata A
PloS one   10(3) e0122582   2015   [Refereed]
Amornwichet N, Oike T, Shibata A, Ogiwara H, Tsuchiya N, Yamauchi M, Saitoh Y, Sekine R, Isono M, Yoshida Y, Ohno T, Kohno T, Nakano T
PloS one   9(12) e115121   2014   [Refereed]
Brunton H, Goodarzi AA, Noon AT, Shrikhande A, Hansen RS, Jeggo PA, Shibata A
Molecular and cellular biology   31 4022-4035   Oct 2011   [Refereed]
Connell CM, Shibata A, Tookman LA, Archibald KM, Flak MB, Pirlo KJ, Lockley M, Wheatley SP, McNeish IA
The Journal of clinical investigation   121 1283-1297   Apr 2011   [Refereed]
Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA
The EMBO journal   30 1079-1092   Mar 2011   [Refereed]
Shibata A, Barton O, Noon AT, Dahm K, Deckbar D, Goodarzi AA, Löbrich M, Jeggo PA
Molecular and cellular biology   30(13) 3371-3383   Jul 2010   [Refereed]
Löbrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, Barton O, Jeggo PA
Cell cycle (Georgetown, Tex.)   9(4) 662-669   Feb 2010   [Refereed]
Noon AT, Shibata A, Rief N, Löbrich M, Stewart GS, Jeggo PA, Goodarzi AA
Nature cell biology   12 177-184   Feb 2010   [Refereed]
Beucher A, Birraux J, Tchouandong L, Barton O, Shibata A, Conrad S, Goodarzi AA, Krempler A, Jeggo PA, Löbrich M
The EMBO journal   28 3413-3427   Nov 2009   [Refereed]
Shibata A, Maeda D, Ogino H, Tsutsumi M, Nohmi T, Nakagama H, Sugimura T, Teraoka H, Masutani M
Mutation research   664 20-27   May 2009   [Refereed]
Sakasai R, Shinohe K, Ichijima Y, Okita N, Shibata A, Asahina K, Teraoka H
Genes to cells : devoted to molecular & cellular mechanisms   11 237-246   Mar 2006   [Refereed]
Shibata A, Masutani M, Kamada N, Masumura K, Nakagama H, Kobayashi S, Teraoka H, Suzuki H, Nohmi T
Environmental and molecular mutagenesis   43 204-207   2004   [Refereed]

Conference Activities & Talks

 
DNA二本鎖切断修復経路の決定メカニズム [Invited]
SHIBATA Atsushi
日本核酸医薬学会生物セッション第4回サテライトシンポジウム   Oct 2019   
Pursuing High-Quality Radiobiology & Radiation Oncology in Indonesia: from basics – clinics – publication [Invited]
SHIBATA Atsushi
IROS Annual Scientific Meeting   Oct 2019   
Regulation of DSB repair pathway choice and its downstream signaling [Invited]
SHIBATA Atsushi
第78回日本癌学会学術総会 シンポジウム「発がん微小環境におけるDNA修復欠損の役割」   Sep 2019   
Regulation of transcription-associated end-joining mediated by MRE11, BRCA1, Polθ and LIG1/3
SHIBATA Atsushi
16th International Congress of Radiation Research 2019   Aug 2019   
Regulation of DNA damage signalling-dependent PD-L1 expression in cancer cells
SHIBATA Atsushi
16th International Congress of Radiation Research 2019   Aug 2019   
A
14th International Workshop on Radiation Damage to DNA   2016   
District regulation of DNA double strand break resection after heavy ion irradiation
The 2015 IMB conference, DNA Repair & Genome Stability in a Chromatin Environment   Jun 2015   
Initiation of homologous recombination repair by MRE11 nuclease activities
Keystone Symposia, Genomic Instability and DNA Repair   Mar 2015   
Initiation of homologous recombination repair by MRE11 nuclease activities
Mechanisms of Recombination: 50th Anniversary Meeting of the Holliday Model   May 2014