2008 - 2010
Possible Mechanisms of Progression of Periodontits by MMP-3 in Diabetic Patients
Japan Society for the Promotion of Science Grants-in-Aid for Scientific Research Grant-in-Aid for Scientific Research (C)
- Grant number
- 20592428
- Japan Grant Number (JGN)
- JP20592428
- Grant amount
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- (Total)
- 4,550,000 Japanese Yen
- (Direct funding)
- 3,500,000 Japanese Yen
- (Indirect funding)
- 1,050,000 Japanese Yen
Diabetic patients are susceptible to severe inflammatory periodontitis. In the present study, we found that high glucose increased MMP-3, but not sIL-6R production in gingival fibroblasts. In addition, sIL-6R production was suppressed by MMP-3 inhibitor in THP-1 macrophages. These results suggest that MMP-3 has a key role in developing severe periodontitis in diabetic patients. Furthermore, it has been considered that IL-6 signals are very important factor surrounding gingival fibroblasts/macrophage interaction in severe periodontitis seen in diabetic patients.
- Link information
- ID information
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- Grant number : 20592428
- Japan Grant Number (JGN) : JP20592428