論文

査読有り
2019年6月

Glucose control using a closed-loop device decreases inflammation after cardiovascular surgery without increasing hypoglycemia risk.

Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs
  • Takahiko Tamura
  • ,
  • Tomoaki Yatabe
  • ,
  • Tsutomu Namikawa
  • ,
  • Kazuhiro Hanazaki
  • ,
  • Masataka Yokoyama

22
2
開始ページ
154
終了ページ
159
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1007/s10047-018-1082-x

Although tight glucose control might reduce inflammation after cardiac surgery, it remains unclear whether inflammation can be controlled by maintaining glucose levels within 110-180 mg/dL. We hypothesized that a glucose target range of 110-180 mg/dL decreases inflammation after cardiovascular surgery. This retrospective study included 72 cardiovascular surgery patients divided into two groups according to the glucose control approach. Patients allocated to the closed-loop group received closed-loop glucose control (target glucose levels at 110-180 mg/dL) from admission to the intensive care unit until 9 a.m. on postoperative day (POD) 1. Patients allocated to the conventional group received conventional glucose control using a sliding scale method to maintain blood glucose levels < 200 mg/dL. Primary outcomes were C-reactive protein (CRP) levels on PODs 1, 2, and 7. Data were reported as mean ± standard deviation. Comparisons were performed using the chi-squared test and unpaired t test, with p < 0.05 indicating statistical significance. The closed-loop group had significantly lower average glucose levels (169 ± 24 vs. 201 ± 36 mg/dL, p < 0.001) and standard deviation of glucose levels (22 ± 13 vs. 44 ± 20 mg/dL; p < 0.001). The CRP levels on PODs 2 and 7 were significantly lower in the closed-loop group than in the conventional group (10.8 ± 5.6 vs. 14.1 ± 5.7 mg/dL, p = 0.02; 4.6 ± 2.5 vs. 7.3 ± 4.0 mg/dL, p < 0.001; respectively). Our findings suggest that glucose control using a closed-loop device might decrease inflammation after cardiovascular surgery without increasing hypoglycemia risk.

リンク情報
DOI
https://doi.org/10.1007/s10047-018-1082-x
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/30456660
ID情報
  • DOI : 10.1007/s10047-018-1082-x
  • PubMed ID : 30456660

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