Ishitani Tohru

J-GLOBAL         Last updated: Nov 11, 2019 at 15:23
 
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Name
Ishitani Tohru
E-mail
ishitanibiken.osaka-u.ac.jp
URL
http://www.biken.osaka-u.ac.jp/en/laboratories/detail/52
Affiliation
Osaka University
Section
RIMD (Biken)
Job title
Professor

Research Areas

 
 

Academic & Professional Experience

 
Nov 2006
 - 
Mar 2011
Kyushu University Medical Institute of Bioregulation
 

Published Papers

 
Yuki Akieda, Shohei Ogamino, Hironobu Furuie, Shizuka Ishitani, Ryutaro Akiyoshi, Jumpei Nogami, Takamasa Masuda, Nobuyuki Shimizu, Yasuyuki Ohkawa & Tohru Ishitani
10 4710   Oct 2019   [Refereed]
Ueda Y, Shimizu Y, Shimizu N, Ishitani T, Ohshima T.
J.Comp. Neurol.   526(15) 2360-2372   Oct 2018   [Refereed]
Watanave M, Hoshino C, Konno A, Fukuzaki Y, Matsuzaki Y, Ishitani T, Hirai H.
Neurobiol Dis.   121 263-273   Oct 2018   [Refereed]
Kulkeaw K, Inoue T, Ishitani T, Nakanishi Y, Zon LI, Sugiyama D
Br J Haematol.   180(3) 420-431   2018   [Refereed]
Akieda Y, Ogamino S, Furuie H, Ishitani S, Akiyoshi R, Nogami JP, Masuda T, Shimizu N, Ohkawa Y, Ishitani T
bioRxiv   423814   Aug 2018
Leong KH, Mahdzir MA, Din MF, Awang K, Tanaka Y, Kulkeaw K, Ishitani T, Sugiyama D.
Phytomedicine   15(26) 11-21   2017   [Refereed]
Wip1 directly dephosphorylates NLK and increases Wnt activity during germ cell development.
Cho SJ, Cha BS, Kwon OS, Lim J, Shin DM, Han DW, Ishitani T, Jho EH, Fornace AJ, Cha HJ.
Biochim. Biophys. Acta   161(1) 1013-1022   2017   [Refereed]
Hippo signaling interactions with Wnt/β-catenin and Notch signaling repress liver tumorigenesis.
Kim W, Khan SK, Gvozdenovic-Jeremic J, Kim Y, Dahlman J, Kim H, Park O, Ishitani T, Jho EH, Gao B, Yang Y.
127(1) 137-152   2016   [Refereed]
Okuno T, Ishitani T, Yokomizo T
PloS one   10(3) e0117888   2015   [Refereed]
In vivo RNAi screen identifies NLK as a negative regulator of mesenchymal activity in glioblastoma.
Sa JK, Yoon Y, Kim M, Kim Y, Cho HJ, Lee JK, Kim GS, Han S, Kim WJ, Shin YJ, Joo KM, Paddison PJ, Ishitani T, Lee J, Nam DH.
Oncotarget   6(24) 20145-59   2015   [Refereed]
Shimizu N, Ishitani S, Sato A, Shibuya H, Ishitani T
Cell reports   8(5) 1391-1404   Sep 2014   [Refereed]
Saita S, Shirane M, Ishitani T, Shimizu N, Nakayama KI
The Journal of biological chemistry   289(37) 25639-25654   Sep 2014   [Refereed]
Delgado ER, Yang J, So J, Leimgruber S, Kahn M, Ishitani T, Shin D, Mustata Wilson G, Monga SP
The American journal of pathology   184(7) 2111-2122   Jul 2014   [Refereed]
Wada H, Ghysen A, Asakawa K, Abe G, Ishitani T, Kawakami K
Current biology : CB   23(16) 1559-1565   Aug 2013   [Refereed]
Ishitani T, Ishitani S
Cellular signalling   25(1) 190-197   Jan 2013   [Refereed]
Shimizu N, Kawakami K, Ishitani T
Developmental biology   370(1) 71-85   Oct 2012   [Refereed]
Kim WT, Kim H, Katanaev VL, Joon Lee S, Ishitani T, Cha B, Han JK, Jho EH
The EMBO journal   31 3384-3397   Aug 2012   [Refereed]
Ishitani T
Cell cycle (Georgetown, Tex.)   11 1743-1745   May 2012   [Refereed]
Ota S, Ishitani S, Shimizu N, Matsumoto K, Itoh M, Ishitani T
The EMBO journal   31 1904-1915   Apr 2012   [Refereed]
[Protein kinase NLK, that fine-tunes the activity of multiple intracellular signaling pathways].
Ishitani T
Seikagaku. The Journal of Japanese Biochemical Society   84 39-42   Jan 2012   [Refereed]
Hozumi S, Hirabayashi R, Yoshizawa A, Ogata M, Ishitani T, Tsutsumi M, Kuroiwa A, Itoh M, Kikuchi Y
PloS one   7 e33675   2012   [Refereed]
Yoshizawa A, Nakahara Y, Izawa T, Ishitani T, Tsutsumi M, Kuroiwa A, Itoh M, Kikuchi Y
Genes to cells : devoted to molecular & cellular mechanisms   16 1097-1109   Nov 2011   [Refereed]
Kulkeaw K, Ishitani T, Kanemaru T, Ivanovski O, Nakagawa M, Mizuochi C, Horio Y, Sugiyama D
Genes to cells : devoted to molecular & cellular mechanisms   16 358-367   Apr 2011   [Refereed]
Ishitani S, Inaba K, Matsumoto K, Ishitani T
Molecular biology of the cell   22 266-277   Jan 2011   [Refereed]
Yamamoto M, Morita R, Mizoguchi T, Matsuo H, Isoda M, Ishitani T, Chitnis AB, Matsumoto K, Crump JG, Hozumi K, Yonemura S, Kawakami K, Itoh M
Development (Cambridge, England)   137 2527-2537   Aug 2010   [Refereed]
Sugiyama K, Nishide K, Matsuo H, Okigawa S, Okano M, Ishitani T, Matsumoto K, Itoh M
Biochemical and biophysical research communications   398 118-124   Jul 2010   [Refereed]
Kulkeaw K, Ishitani T, Kanemaru T, Fucharoen S, Sugiyama D
Biochemical and biophysical research communications   394 859-864   Apr 2010   [Refereed]
Tsukada Y, Ishitani T, Nakayama KI
Genes & development   24 432-437   Mar 2010   [Refereed]
Ishitani T, Hirao T, Suzuki M, Isoda M, Ishitani S, Harigaya K, Kitagawa M, Matsumoto K, Itoh M
Nature cell biology   12 278-285   Mar 2010   [Refereed]
Ohnishi E, Goto T, Sato A, Kim MS, Iemura S, Ishitani T, Natsume T, Ohnishi J, Shibuya H
Molecular and cellular biology   30 675-683   Feb 2010   [Refereed]
Ishitani T, Ishitani S, Matsumoto K, Itoh M
Journal of neurochemistry   111 1104-1118   Dec 2009   [Refereed]
Lee W, Swarup S, Chen J, Ishitani T, Verheyen EM
Development (Cambridge, England)   136 241-251   Jan 2009   [Refereed]
Ishitani T, Matsumoto K, Chitnis AB, Itoh M
Nature cell biology   7 1106-1112   Nov 2005   [Refereed]
Kojima H, Sasaki T, Ishitani T, Iemura S, Zhao H, Kaneko S, Kunimoto H, Natsume T, Matsumoto K, Nakajima K
Proceedings of the National Academy of Sciences of the United States of America   102 4524-4529   Mar 2005   [Refereed]
Kanei-Ishii C, Ninomiya-Tsuji J, Tanikawa J, Nomura T, Ishitani T, Kishida S, Kokura K, Kurahashi T, Ichikawa-Iwata E, Kim Y, Matsumoto K, Ishii S
Genes & development   18 816-829   Apr 2004   [Refereed]
Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K
The EMBO journal   22 6277-6288   Dec 2003   [Refereed]
Ishitani T, Ninomiya-Tsuji J, Matsumoto K
Molecular and cellular biology   23 1379-1389   Feb 2003   [Refereed]
Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K
Molecular and cellular biology   23 131-139   Jan 2003   [Refereed]
Meneghini MD, Ishitani T, Carter JC, Hisamoto N, Ninomiya-Tsuji J, Thorpe CJ, Hamill DR, Matsumoto K, *Bowerman B
Nature   399 793-797   1999   [Refereed]
Ishitani T, Ninomiya-Tsuji J, Nagai S, Nishita M, Meneghini M, Barker N, Waterman M, Bowerman B, Clevers H, Shibuya H, *Matsumoto K
Nature   399 798-802   1999   [Refereed]

Misc

 
Kim, Wantae; Khan, Sanjoy Kumar; Gvozdenovic-Jeremic, Jelena; Kim, Youngeun; Dahlman, Jason; Kim, Hanjun; Park, Ogyi; Ishitani, Tohru; Jho, Eek-Hoon; Gao, Bin; Yang, Yingzi
JOURNAL OF CLINICAL INVESTIGATION   127(1) 137-152   2017
Wada, Hironori; Ghysen, Alain; Asakawa, Kazuhide; Abe, Gembu; Ishitani, Tohru; Kawakami, Koichi
CURRENT BIOLOGY   23(16) 1559-1565   2013
Delgado, Evan R.; Yang, Jing; So, Juhoon; Leimgruber, Stephanie; Kahn, Michael; Ishitani, Tohru; Shin, Donghun; Wilson, Gabriela Mustata; Monga, Satdarshan P.
AMERICAN JOURNAL OF PATHOLOGY   184(7) 2111-2122   2014
Sa, Jason K.; Yoon, Yeup; Kim, Misuk; Kim, Yeonghwan; Cho, Hee Jin; Lee, Jin-Ku; Kim, Gi-Soo; Han, Suji; Kim, Woon Jin; Shin, Yong Jae; Joo, Kyeung Min; Paddison, Patrick J.; Ishitani, Tohru; Lee, Jeongwu; Nam, Do-Hyun
ONCOTARGET   6(24) 20145-20159   2015
Leong, Kok Hoong; Mahdzir, Mohamad Azrul; Din, Mohd Fadzli Md; Awang, Khalijah; Tanaka, Yuka; Kulkeaw, Kasem; Ishitani, Tohru; Sugiyama, Daisuke
PHYTOMEDICINE   26 11-21.   2017

Books etc

 
Cell Signaling: principles and mechanisms (Garland Sciences)
2016   
Nemo-like kinase, a multifaceted cell signaling regulator.
Cell Signal   2013   
Context-dependent dual and opposite roles of nemo-like kinase in the Wnt/β-catenin signaling.
Cell Cycle   2012   
Encyclopedia of Signaling Molecules, 2nd Edition
Springer社   2017   
Protein modifications in pathogenic dysregulation of signaling
Springer社   2015   

Conference Activities & Talks

 
Cell competition supports robustness of embryonic patterning: a new system correcting distortion of the Wnt/β-catenin signaling activity gradient
Japanese Society of Developmental Biologists 50th   2017   
The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning
Cell competition in Develeopment and Cancer   2018   
The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning.
International Symposium of Cell Competition   2017   
The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning.
Gordon Research Conference Wnt signaling   2017   
The noise-cancelling system supporting precise Wnt/β-catenin signaling-mediated vertebrate tissue patterning.
Conbio2017   2017   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(挑戦的萌芽研究)
Project Year: 2011 - 2012    Investigator(s): Tohru ISHITANI
During axis-formation in vertebrate tissues, cells sense the concentration of Wnt ligands and convert its information into the digital information that directs the regulation of selective gene expression. In this study, we investigated this Wnt si...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(A))
Project Year: 2010 - 2012    Investigator(s): Tohru ISHITANI
NLK is an evolutionarily conserved protein kinase, which fine-tunes the activity strength of various signal transduction systems. In this study, we discovered that NLK strengthen Wnt signaling activity by phosphorylating a transcription factor Lef...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(A))
Project Year: 2007 - 2009    Investigator(s): Tohru ISHITANI
Nemo-like kinase is a conserved protein kinase. In this study, we found that NLK promotes neurogenesis via phosphorylating Notch1 and that NLK contribute to neurite outgrowth via phosphorylating paxillin and MAP1B downstream of NGF signaling.