Miyoko Kubo

Profile Information

Affiliation: Graduate School of Medicine , Dentistry and Pharmaceutical Sciences, Okayama University

Degree: Ph.D.(Shinshu University)

J-GLOBAL ID: 201001096938014635
researchmap Member ID: 6000021166

Research Interests

Research Areas

Life sciences / Dermatology /

Research History

Apr, 2023 - Present

客員研究員, 分子医化学分野, 岡山大学大学院医歯薬学総合研究科
Apr, 2012 - Mar, 2023

Graduate School of Medicine , Dentistry and Pharmaceutical Sciences, Okayama University
Apr, 2002 - Mar, 2012

Kawasaki Medical School
Jul, 1998 - Mar, 2002

Kawasaki Medical School
Dec, 1994 - May, 1998

ニューヨーク州立大学医学部皮膚科 visiting scientist
Feb, 1990 - Aug, 1994

Shinshu University Hospital, Clinical Division of Dermatology, Shinshu University
Apr, 1989 - Jan, 1990

諏訪赤十字病院皮膚科医長
Apr, 1988 - Mar, 1989

Shinshu University Hospital, Clinical Division of Dermatology, Shinshu University
Apr, 1986 - Mar, 1988

信州大学医学部第一解剖学助手
Oct, 1983 - Mar, 1986

東北大学医学部附属病院皮膚科医員、助手
Aug, 1983 - Sep, 1983

Medical School, Okayama University
Dec, 1980 - Jun, 1983

リサーチ・フェロー, コロラド大学医学部皮膚科学教室
Jan, 1977 - Oct, 1980

Medical School, Okayama University
Jun, 1974 - Dec, 1976

Kawasaki Medical School
Jun, 1973 - May, 1974

Faculty of Medicine University Hospital, The University of Tokyo
Apr, 1972 - May, 1973

Faculty of Medicine University Hospital, The University of Tokyo
Jun, 1971 - Mar, 1972

中央鉄道病院皮膚科研修医

Education

- 1971

School of Medicine, Shinshu University

Papers

Expression of tumor suppressor REIC/Dkk-3 by a newly improved adenovirus vector with insertion of a hTERT promoter at the 3′-side of the transgene

Endy Widya Putranto, Rie Kinoshita, Masami Watanabe, Takuya Sadahira, Hitoshi Murata, Ken-Ichi Yamamoto, Junichiro Futami, Ken Kataoka, Yusuke Inoue, I. Made Winarsa Ruma …

Oncology Letters, 14(1) 1041-1048, Jul, 2017 Peer-reviewed
Tranilast inhibits the cell growth of normal human keratinocytes in vitro

Miyoko Kubo, Ying Zhao, Takahiko Moriguchi

ARCHIVES OF DERMATOLOGICAL RESEARCH, 304(9) 745-753, Nov, 2012 Peer-reviewed
Attached lysate with Fiblast Spray and benzalkonium chloride were cytotoxic to normal human keratinocytes and fibroblasts cultured on type 1 collagen

Japanese journal of dermatology, 121(8) 1607-1620, 2011 Peer-reviewed
Transduction of beta 3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to gelatin

Miyoko Kubo, Richard A. F. Clark, Anne B. Katz, Lorne B. Taichman, Zaishun Jin, Ying Zhao, Takahiko Moriguchi

ARCHIVES OF DERMATOLOGICAL RESEARCH, 299(1) 13-24, Apr, 2007 Peer-reviewed
肥厚性瘢痕，ケロイドでの血管新生

久保美代子, 森口隆彦

医学のあゆみ, 219(7) 513-516, 2006 Invited
Effects of bFGF on the Cell Growth of Keratinocytes

Kubo Miyoko, Moriguchi Takahiko

Hifu no kagaku, 5(増6) 16-20, 2006 Invited
Gelatin microspheres crosslinked with gamma-ray: Preparation, sorption of proteins, and biodegradability

K Terao, T Karino, N Nagasawa, F Yoshii, M Kubo, T Dobashi

JOURNAL OF APPLIED POLYMER SCIENCE, 91(5) 3083-3087, Mar, 2004 Peer-reviewed
Fibrinogen and fibrin are anti-adhesive for keratinocytes: A mechanism for fibrin eschar slough during wound repair

M Kubo, L Van De Water, LC Plantefaber, MW Mosesson, M Simon, MG Tonnesen, L Taichman, RAF Clark

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 117(6) 1369-1381, Dec, 2001 Peer-reviewed
インテグリンと再上皮化

久保美代子

医学のあゆみ, 195(2) 146-147, 2000 Peer-reviewed
きれいな傷あと形成のための創傷治癒の促進機序

久保美代子, 森口隆彦

形成外科, 42(増刊号) S5-S13, 1999 Invited
IMMUNOELECTRON MICROSCOPIC LOCALIZATION OF FIBRONECTIN IN CULTURED HUMAN KERATINOCYTES

M KUBO, S OHNO, M KATO, M ISEMURA, H TAGAMI, T SAIDA

ARCHIVES OF DERMATOLOGICAL RESEARCH, 286(8) 448-454, Oct, 1994 Peer-reviewed
EFFECTS OF EXTRACELLULAR MATRICES ON HUMAN KERATINOCYTE ADHESION AND GROWTH AND ON ITS SECRETION AND DEPOSITION OF FIBRONECTIN IN CULTURE

M KUBO, M KAN, M ISEMURA, YAMANE, I, H TAGAMI

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 88(5) 594-601, May, 1987 Peer-reviewed
フィブロネクチン

久保美代子

皮膚科の臨床, 28(10) 1169-1178, 1986 Peer-reviewed
ULTRAVIOLET-LIGHT INDUCES BINDING OF ANTIBODIES TO SELECTED NUCLEAR ANTIGENS ON CULTURED HUMAN KERATINOCYTES

WP LEFEBER, DA NORRIS, RYAN, SR, JC HUFF, LA LEE, M KUBO, ST BOYCE, BL KOTZIN, WL WESTON

JOURNAL OF CLINICAL INVESTIGATION, 74(4) 1545-1551, 1984 Peer-reviewed
THE ROLE OF RNP, SM, AND SS-A/RO-SPECIFIC ANTISERA FROM PATIENTS WITH LUPUS-ERYTHEMATOSUS IN INDUCING ANTIBODY-DEPENDENT CELLULAR CYTO-TOXICITY (ADCC) OF TARGETS COATED WITH NONHISTONE NUCLEAR ANTIGENS

DA NORRIS, RYAN, SR, KA FRITZ, M KUBO, EM TAN, JS DENG, WL WESTON

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 31(3) 311-320, 1984 Peer-reviewed
HUMAN KERATINOCYTES SYNTHESIZE, SECRETE, AND DEPOSIT FIBRONECTIN IN THE PERICELLULAR MATRIX

M KUBO, DA NORRIS, SE HOWELL, RYAN, SR, RAF CLARK

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 82(6) 580-586, 1984 Peer-reviewed
The morphology and time course of immune complexes injected into the skin of rabbits.

Hiroaki Ueki, Miyoko Kubo, Masako Nakane, Tadahiro Aoshima, Toshiki Masuda

J Dermatol, 6(3) 173-178, 1979 Peer-reviewed
Trans-epidermal elimination of immune deposits in the skin. An immunohistochemical study of immune deposits using horseradish peroxidase as antigen.

Hiroaki Ueki, Miyoko Kubo, Toshiki Masuda, Nozomi Nohara

J Dermatol, 3(5) 209,-213, 1976 Peer-reviewed
Immune deposits in the skin of reversed passive Arthus reaction. The effects of the administration of the corticosteroid.

Miyoko Kubo, Hiroaki Ueki, Nozomi Nohara

J Dermatol, 3(6) 323-329, 1976 Peer-reviewed
良性Ｍタンパク血症を伴ったgeneralized discoid lupus erythematosusおよびその免疫学的考察

植木宏明, 久保美代子, 三好薫, 月野木清徳, 土屋敏子, 野原望

内科, 36(4) 671-679, 1975 Peer-reviewed

Misc.

β3インテグリン遺伝子導入ヒト表皮角化細胞を用いた難治性潰瘍に対する新規再生医療の開発

久保美代子, 山本健一, 木下理恵, 米澤朋子, 大橋俊孝, 阪口政清

日本結合組織学会学術大会プログラム・抄録集, 55回 134-134, Jun, 2023
Beta3インテグリン・サブユニットcDNA導入ケラチノサイトを用いた培養表皮の開発―生着率向上に向けて―

久保美代子, 森口隆彦, 前原奈都美, 片岡健, 許南浩, 稲川喜一

再生医療, 10 254, Feb 1, 2011
FIBRONECTIN DISTRIBUTION WITH PRESSURE ULCERS SIGNIFICANTLY DECREASED IN THE PAPILLARY DERMIS UNDER THE MIGRATING EPIDERMIS COMPARED WITH THOSE OF BURNS

Miyoko Kubo, Takahiko Moriguchi, Natsumi Maehara, Kiichi Inagawa

WOUND REPAIR AND REGENERATION, 18(6) A86-A86, Nov, 2010
Transduction of beta 3 integrin subunit cDNA confers on human keratinocytes the ability to adhere to gelatin

Miyoko Kubo, Richard A. F. Clark, Anne B. Katz, Lorne B. Taichman, Zaishun Jin, Ying Zhao, Takahiko Moriguchi

ARCHIVES OF DERMATOLOGICAL RESEARCH, 299(1) 13-24, Apr, 2007
Tranilast inhibits the cell growth of normal human keratinocytes in vitro

Miyoko Kubo, Ying Zhao, Takahiko Moriguchi

WOUND REPAIR AND REGENERATION, 15(2) A21-A21, Mar, 2007
Decrease in alpha 5 beta 1 expression in the migrating epidermis and fibronectin distribution under the migrating epidermis are mechanisms of delayed re-epithelialization with pressure ulcers

Miyoko Kubo, Yi-Xuan Liu, Ying Zhao, Takahiko Moriguchi

WOUND REPAIR AND REGENERATION, 15(2) A30-A30, Mar, 2007
Gelatin microspheres crosslinked with gamma-ray: Preparation, sorption of proteins, and biodegradability

K Terao, T Karino, N Nagasawa, F Yoshii, M Kubo, T Dobashi

JOURNAL OF APPLIED POLYMER SCIENCE, 91(5) 3083-3087, Mar, 2004
Keratinocytes do not adhere to fibrinogen or fibrin.

M Kubo, M Simon, RAF Clark

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 106(4) 142-142, Apr, 1996
CYTOSKELETONS, EXTRACELLULAR MATRICES AND EXTRACELLULAR-MATRIX RECEPTORS ARE ALTERED IN CUTANEOUS SQUAMOUS-CELL CARCINOMA

M KUBO, T SAIDA

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 104(4) 642-642, Apr, 1995
EXTRACELLULAR MATRICES AFFECT THE SECRETION AND DEPOSITION OF FIBRONECTIN BY HUMAN KERATINOCYTES AND THEIR GROWTH IN CULTURE

M KUBO, M KAN, M ISEMURA, YAMANE, I, H TAGAMI

CLINICAL RESEARCH, 33(2) A658-A658, 1985
EXTRACELLULAR MATRICES AFFECT THE SECRETION AND DEPOSITION OF FIBRONECTIN BY HUMAN KERATINOCYTES AND THEIR GROWTH IN CULTURE

M KUBO, M KAN, M ISEMURA, YAMANE, I, H TAGAMI

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 84(4) 351-351, 1985
NONSTRATIFYING CULTURED HUMAN KERATINOCYTES SYNTHESIZE BOTH LAMININ AND FIBRONECTIN BUT ONLY DEPOSIT FIBRONECTIN IN THE PERICELLULAR MATRIX

RAF CLARK, SE HOWELL, M KUBO, DA NORRIS

FEDERATION PROCEEDINGS, 43(4) 993-993, 1984
PRODUCTION OF FIBRONECTIN BY HUMAN KERATINOCYTE CULTURES

M KUBO, DA NORRIS, RYAN, SR, P NAKANE, RAF CLARK

CLINICAL RESEARCH, 31(2) A580-A580, 1983
INDUCTION OF NUCLEAR ANTIGEN EXPRESSION IN HUMAN KERATINOCYTES BY ULTRAVIOLET-LIGHT (UVL)

WP LEFEBER, DA NORRIS, JC HUFF, M KUBO, RYAN, SR, WL WESTON

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 80(4) 328-328, 1983
INDUCTION OF NUCLEAR ANTIGEN EXPRESSION IN HUMAN KERATINOCYTES BY ULTRAVIOLET-LIGHT (UVL)

WP LEFEBER, DA NORRIS, JC HUFF, M KUBO, RYAN, SR, WL WESTON

CLINICAL RESEARCH, 31(2) A581-A581, 1983
INDUCTION OF NUCLEAR ANTIGEN EXPRESSION IN HUMAN KERATINOCYTES BY ULTRAVIOLET-LIGHT (UVL)

WP LEFEBER, DA NORRIS, JC HUFF, M KUBO, RYAN, SR, WL WESTON

CLINICAL RESEARCH, 31(1) A148-A148, 1983
PRODUCTION OF FIBRONECTIN BY HUMAN KERATINOCYTE CULTURES

M KUBO, DA NORRIS, RYAN, SR, T HARTMAN, RAF CLARK

CLINICAL RESEARCH, 31(1) A148-A148, 1983
PRODUCTION OF FIBRONECTIN BY HUMAN KERATINOCYTE CULTURES

M KUBO, DA NORRIS, RYAN, SR, P NAKANE, RAF CLARK

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 80(4) 304-304, 1983
DENSITY GRADIENT ENRICHMENT OF EPIDERMAL LANGERHANS CELLS AND SUBSEQUENT RECEPTOR FUNCTION

M KUBO, RAF CLARK, DA NORRIS

CLINICAL RESEARCH, 30(1) A157-A157, 1982
COMPARISON OF FIBRONECTIN RECEPTORS ON GUINEA-PIG MONOCYTES, MACROPHAGES AND LANGERHANS CELLS

M KUBO, RAF CLARK, DA NORRIS

CLINICAL RESEARCH, 30(2) A592-A592, 1982

Books and Other Publications

現代発生生物学シリーズ2 器官形成発生生物学から臓器工学まで〈器官形成研究会編）

伊勢村護, 久保美代子 (Role: Joint author, 第4章基底膜 pp48-56)

〈器官形成研究会編）培風館東京, 1988
慢性創傷の創傷治癒「形成外科ADVANCEシリーズI-3 創傷の治療最近の進歩」

久保美代子, 森口隆彦

克誠堂出版

Presentations

Beta3インテグリンcDNA導入ヒトケラチノサイトは正常ヒトケラチノサイトに比べてフィブリンゲル上で細胞増殖が増加する

久保美代子, 阪口政清

第89回組織培養学会, May 25, 2016
The development of improved cultured epithelium using β3 cDNA-transduced keratinocytes to increase its take-rate.

Miyoko Kubo, Takahiko Moriguchi, Natsumi Maehara, Ken Kataoka, Nam-ho HU, KiichiInagawa

17th International Society for Cellular Therapy Annual Meeting, May 17, 2011
Beta3インテグリン・サブユニットcDNA導入ケラチノサイトを用いた培養表皮の開発―生着率向上に向けて―

久保美代子, 森口隆彦, 前原奈都美, 片岡健, 許南浩, 稲川喜一

第10回日本再生医療学会総会, Mar 1, 2011
Fibronectin distribution with pressure ulcers significantly decreased in the papillary dermis under the migrating epidermis compared with those of burns.

Miyoko Kubo, Takahiko Moriguchi, Natsumi Maehara, Kiichi Inagawa

20th European Tissue Repair Society Congress, Sep 15, 2010
bFGFのケラチノサイト、線維芽細胞への細胞増殖促進効果とフィブラストⓇスプレー添付溶解液の細胞毒性

久保美代子, 森口隆彦, 稲川喜一

第2回日本創傷外科学会, Jul 30, 2010
bFGFはⅠ型コラーゲン上で培養した正常ヒトケラチノサイト、正常ヒト線維芽細胞の細胞増殖を濃度依存性に促進する―フィブラストスプレー添付溶解液の細胞毒性による影響―

久保美代子, 森口隆彦

第59回日本形成外科学会中国∙四国支部学術集会, Feb 21, 2010
褥瘡では熱傷に比べて真皮内の種々の部位でフィブロネクチン分布が減少する

久保美代子, 森口隆彦

第１回日本創傷外科学会, Jan 16, 2009
ヒトケラチノサイト、線維芽細胞のin vitroでの細胞増殖に対するbFGF の効果―フィブラストスプレーとbFGF原末との比較―

久保美代子, 森口隆彦

第６回bFGF創傷治癒研究会, Oct 24, 2008
Decrease in a5b1 expression in the migrating epidermis and fibronectin distribution under the migrating epidermis are mechanisms of delayed re-epithelialization with pressure ulcers.

Miyoko Kubo, Takahiko Moriguchi

The Wound Healing Society 17th Annual Meeting & Exhibition (SAWC & WHS 2007)., Jun 4, 2008
Basic fibroblast growth factor increases cell growth of normal human keratinocytes and fibroblasts in extracellular matrix- and dose-dependent manners.

The Third World Union of Wound Healing Societies’ Meeting, 2008
Tranilast inhibits the cell growth of normal human keratinocytes in vitro.

The Wound Healing Society 17th Annual Meeting & Exhibition (SAWC & WHS 2007)., 2007
Decrease in a5b1 expression in the migrating epidermis and fibronectin distribution under the migrating epidermis are mechanisms of delayed re-epithelialization with pressure ulcers.

The Wound Healing Society 17th Annual Meeting & Exhibition (SAWC & WHS 2007)., 2007
トラニラストは培養正常ヒトケラチノサイトの細胞増殖を抑制する

久保美代子, 森口隆彦

第15回日本形成外科学会基礎学術集会, 2006
慢性創傷における再上皮化遅延の機序解明—創傷治癒理論に基づいた治療法の確立を目指してー

久保美代子, 森口隆彦

第14回日本形成外科学会基礎学術集会, 2005
難治性皮膚潰瘍の病態解析ー褥瘡での再上皮化遅延の病態ー

久保美代子, 森口隆彦

第47回日本形成外科学会総会学術大会, 2004
種々の細胞外基質上でのヒトケラチノサイト、線維芽細胞の細胞増殖に対するbFGFの効果について

久保美代子, 森口隆彦

第13回日本形成外科学会基礎学術集会, 2004
DECRESE OF A5B1 EXPRESSION IS CORRELATED WITH INHIBITION OF THE EPIDERMAL CELL MIGRATION DURING THE REEPITHELIALIZATION PROCESS OF PRESSURE ULCERS.

The 2nd World Union of Wound Healing Society Meeting., 2004
Transduction of beta3 integrin subunit cDNA confers on human keratinocytes to migrate to fibrinogen, vitronectin and gelatin.

The 2nd World Union of Wound Healing Society Meeting., 2004
b3インテグリン・サブユニットcDNA導入ヒトケラチノサイトのビトロネクチンに対する細胞移動能の獲得について

久保美代子, 森口隆彦

第12回日本形成外科学会基礎学術集会, Oct 9, 2003
Suprabasal expression of a5b1 is an indicator of epidermal cell migration during the re-epithelialization process of acute wounds.

The Wound Healing Society 13th Annual Educational Symposium & Exhibition,, May 4, 2003

Professional Memberships

Works

beta3インテグリン組み換え型培養表皮の開発

Apr, 2000 - Mar, 2001

Research Projects

難治性潰瘍での変性コラーゲンの局在証明、再上皮化遅延の病態解明とその治療法開発

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2023 - Mar, 2026

久保美代子
β3インテグリン遺伝子導入ヒト表皮角化細胞を用いた難治性潰瘍に対する新規再生医療

科学研究費助成事業基盤研究(C), 基盤研究(C), 日本学術振興会, Apr, 2020 - Mar, 2023

久保美代子, 牧野英一, 山本健一, 木下理恵
慢性創傷での再上皮化促進のための再生医療の確立―再上皮化機序に基づいて―

日本学術振興会, Apr, 2011 - Mar, 2013

久保美代子
動物実験によるbeta3インテグリン組み換え型培養表皮の有効性の検証

日本学術振興会, Apr, 2008 - Mar, 2011

久保美代子
慢性創傷における再上皮化遅延の機序解明ー創傷治癒理論に基づいた治療法の確立を目指してー

日本学術振興会, Apr, 2005 - Mar, 2007

久保美代子
beta3インテグリン組み換え型培養表皮の開発ー生着率向上に向けて

日本学術振興会, Apr, 2003 - Mar, 2005

久保美代子
慢性潰瘍部での遊走表皮細胞インテグリン発現の変化、真皮細胞外基質蛋白の解析

日本学術振興会, Apr, 2001 - Mar, 2003

久保美代子

Industrial Property Rights

RECONBINANT KERATINOCYTES

Profile Information

Research Interests

Research Areas

Research History

Education

Papers

Misc.

Books and Other Publications

Presentations

Professional Memberships

Works

Research Projects

Industrial Property Rights

Menu

Coauthors