黒川 洵子


黒川 洵子

J-GLOBALへ         更新日: 18/09/27 18:16
 
アバター
研究者氏名
黒川 洵子
 
クロカワ ジュンコ
eメール
junkokurou-shizuoka-ken.ac.jp
URL
http://w3pharm.u-shizuoka-ken.ac.jp/rinsho/
所属
静岡県立大学
部署
薬学部
職名
教授
学位
薬学博士(東京大学)
科研費研究者番号
40396982
ORCID ID
0000-0002-9098-0908

研究分野

 
 

経歴

 
2016年11月
 - 
現在
静岡県立大学 薬学部 教授
 
2006年7月
 - 
2016年10月
東京医科歯科大学 難治疾患研究所 准教授
 
2004年9月
 - 
2006年6月
東京医科歯科大学 難治疾患研究所 助手
 
2003年7月
 - 
2004年8月
日本学術振興会 海外特別研究員
 
2003年7月
 - 
2004年8月
コロンビア大学 医学部 リサーチアソシエート
 

学歴

 
1995年4月
 - 
1998年3月
東京大学 薬学系研究科 生命薬学専攻
 
1995年
 - 
1998年
University of Tokyo, Graduate School Pharmaceutical Sciences PhD
 
1993年4月
 - 
1995年3月
東京大学 薬学系研究科 
 
1993年
 - 
1995年
University of Tokyo, Graduate School Pharmaceutical Sciences MS
 
1989年4月
 - 
1993年3月
東京大学 薬学部 
 

委員歴

 
2017年10月
 - 
現在
日本学術会議  連携会員
 

受賞

 
 
日本薬学会学術奨励賞
 
 
文部科学大臣若手科学者表彰
 
 
American Heart Assication Melvin Marcus Award Finalist
 

論文

 
Okada JI, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T
British journal of pharmacology   175(17) 3435-3452   2018年9月   [査読有り]
Miyamoto K, Akiyama M, Tamura F, Isomi M, Yamakawa H, Sadahiro T, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tani H, Wang L, Qian L, Inoue M, Ide Y, Kurokawa J, Yamamoto T, Seki T, Aeba R, Yamagishi H, Fukuda K, Ieda M
Cell stem cell      2017年12月   [査読有り]
Pei Chi Yang, Laura L. Perissinotti, Fernando López-Redondo, Yibo Wang, Kevin R. DeMarco, Mao Tsuen Jeng, Igor Vorobyov, Robert D. Harvey, Junko Kurokawa, Junko Kurokawa, Sergei Y. Noskov, Colleen E. Clancy
Journal of Physiology   595 4695-4723   2017年7月   [査読有り]
© 2017 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society Key points: This study represents a first step toward predicting mechanisms of sex-based arrhythmias that may lead to importa...
Min Li, Yasunari Kanda, Takashi Ashihara, Tetsuo Sasano, Yuji Nakai, Masami Kodama, Erina Hayashi, Yuko Sekino, Yuko Sekino, Tetsushi Furukawa, Junko Kurokawa, Junko Kurokawa
Journal of Pharmacological Sciences   134 75-85   2017年6月   [査読有り]
© 2017 The Authors Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature function...
Kodama M, Kurokawa J
Annals of translational medicine   5(4) 88   2017年2月   [査読有り]
Shugo Tohyama, Shugo Tohyama, Jun Fujita, Chihana Fujita, Miho Yamaguchi, Sayaka Kanaami, Rei Ohno, Kazuho Sakamoto, Kazuho Sakamoto, Masami Kodama, Junko Kurokawa, Hideaki Kanazawa, Tomohisa Seki, Yoshikazu Kishino, Marina Okada, Kazuaki Nakajima, Sho Tanosaki, Shota Someya, Akinori Hirano, Shinji Kawaguchi, Eiji Kobayashi, Keiichi Fukuda
Stem Cell Reports      2017年1月   [査読有り]
© 2017 The Author(s). Cardiac regenerative therapies utilizing human induced pluripotent stem cells (hiPSCs) are hampered by ineffective large-scale culture. hiPSCs were cultured in multilayer culture plates (CPs) with active gas ventilation (AGV)...
Shinichiro Okata, Shinichiro Okata, Shinsuke Yuasa, Tomoyuki Suzuki, Tomoyuki Suzuki, Shogo Ito, Naomasa Makita, Tetsu Yoshida, Min Li, Junko Kurokawa, Tomohisa Seki, Toru Egashira, Yoshiyasu Aizawa, Masaki Kodaira, Chikaaki Motoda, Gakuto Yozu, Masaya Shimojima, Nozomi Hayashiji, Hisayuki Hashimoto, Yusuke Kuroda, Yusuke Kuroda, Atsushi Tanaka, Mitsushige Murata, Mitsushige Murata, Takeshi Aiba, Wataru Shimizu, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Tetsushi Furukawa, Keiichi Fukuda
Scientific Reports   6    2016年9月   [査読有り]
© The Author(s) 2016. SCN5A is abundant in heart and has a major role in I Na. Loss-of-function mutation in SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains unclear why disease phenotype does not manifest in...
Kanda Y, Ashihara T, Kurokawa J
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   147(6) 334-338   2016年6月   [査読有り]
Fernando López-Redondo, Junko Kurokawa, Fumimasa Nomura, Tomoyuki Kaneko, Tomoyo Hamada, Tetsushi Furukawa, Kenji Yasuda
Journal of Pharmacological Sciences   131 141-145   2016年6月   [査読有り]
© 2016 The Authors We investigated electrophysiological properties of human induced-pluripotent-stem-cell-derived and embryonic-stem-cell-derived cardiomyocytes, and analyzed action potential parameters by plotting their frequency distributions. I...
Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T
Journal of molecular and cellular cardiology   90 38-46   2016年1月   [査読有り]
Nagamori S, Wiriyasermkul P, Guarch ME, Okuyama H, Nakagomi S, Tadagaki K, Nishinaka Y, Bodoy S, Takafuji K, Okuda S, Kurokawa J, Ohgaki R, Nunes V, Palacín M, Kanai Y
Proceedings of the National Academy of Sciences of the United States of America   113(3) 775-780   2016年1月   [査読有り]
Koji Sugiyama, Koji Sugiyama, Tetsuo Sasano, Tetsuo Sasano, Tetsuo Sasano, Junko Kurokawa, Kentaro Takahashi, Kentaro Takahashi, Tadashi Okamura, Tadashi Okamura, Norihiro Kato, Mitsuaki Isobe, Tetsushi Furukawa
International Heart Journal   57(3) 341-349   2016年1月   [査読有り]
© 2016, International Heart Journal Association. All rights reserved. Genome-wide association study has identified that the genetic variations at NOS1AP (neuronal nitric oxide syn-thase-1 adaptor protein) were associated with QT interval and sudde...
Sall1 transiently marks undifferentiated heart precursors and regulates their fate.
Morita Y, Andersen P, Hotta A, Sasagawa N, Kurokawa J, Tsukahara Y, Hayashida N, Koga C, Nishikawa M, Evans SM, Furukawa T, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK
Journal of Molecular Cellular Cardiology   92 158-162   2016年   [査読有り]
Yamakawa H, Muraoka N, Miyamoto K, Sadahiro T, Isomi M, Haginiwa S, Kojima H, Umei T, Akiyama M, Kuishi Y, Kurokawa J, Furukawa T, Fukuda K, Ieda M
Stem cell reports   5(6) 1128-1142   2015年12月   [査読有り]
Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T
Science advances   1(4) e1400142   2015年5月   [査読有り]
Junko Kurokawa, Tetsuo Sasano, Masami Kodama, Min Li, Yusuke Ebana, Nobuhiro Harada, Shin Ichiro Honda, Haruaki Nakaya, Tetsushi Furukawa
Journal of Toxicological Sciences   40 339-348   2015年1月   [査読有り]
© 2015, Japanese Society of Toxicology. All rights reserved. Our in vitro characterization showed that physiological concentrations of estrogen partially suppressed the IKr channel current in guinea pig ventricular myocytes and the human ether-a-g...
Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H
PloS one   10(9) e0138193   2015年   [査読有り]
Mahoko Asayama, Mahoko Asayama, Junko Kurokawa, Kiyoshi Shirakawa, Hisashi Okuyama, Toshiki Kagawa, Jun Ichi Okada, Seiryo Sugiura, Toshiaki Hisada, Tetsushi Furukawa
Journal of Pharmacological Sciences   121 1-8   2013年2月   [査読有り]
In short QT syndrome, inherited gain-of-function mutations in the human ether a-go-go-related gene (hERG) K + channel have been associated with development of fatal arrhythmias. This implies that drugs that activate hERG as a side effect may like...
Hayakawa Tomohiro, Kunihiro Takeshi, Ando Tomoko, Uno Hatsume, Kobayashi Seiji, Matsui Eriko, Yada Hiroaki, Kanda Yasunari, Kurokawa Junko, Furukawa Tetsushi
Journal of Pharmacological and Toxicological Methods   68(1) E24   2013年   [査読有り]
Toru Egashira, Shinsuke Yuasa, Shinsuke Yuasa, Tomoyuki Suzuki, Tomoyuki Suzuki, Yoshiyasu Aizawa, Hiroyuki Yamakawa, Tomohiro Matsuhashi, Yohei Ohno, Shugo Tohyama, Shinichiro Okata, Tomohisa Seki, Yusuke Kuroda, Yusuke Kuroda, Kojiro Yae, Hisayuki Hashimoto, Tomofumi Tanaka, Tomofumi Tanaka, Fumiyuki Hattori, Fumiyuki Hattori, Toshiaki Sato, Shunichiro Miyoshi, Seiji Takatsuki, Mitsushige Murata, Mitsushige Murata, Junko Kurokawa, Tetsushi Furukawa, Naomasa Makita, Takeshi Aiba, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Itsuo Kodama, Satoshi Ogawa, Keiichi Fukuda
Cardiovascular Research   95 419-429   2012年9月   [査読有り]
Aims Long QT syndrome (LQTS) is an inheritable and life-threatening disease; however, it is often difficult to determine disease characteristics in sporadic cases with novel mutations, and more precise analysis is necessary for the successful deve...
Hiroki Sugiyama, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Morita, Satoshi Akagi, Yoshinori Tani, Yusuke Katayama, Nobuhiro Nishii, Toru Miyoshi, Toru Miyoshi, Satoshi Nagase, Kunihisa Kohno, Kengo Fukushima Kusano, Tohru Ohe, Junko Kurokawa, Tetsushi Furukawa, Hiroshi Ito
PLoS ONE   6    2011年5月   [査読有り]
Background: It is estimated that approximately half of the deaths in patients with HF are sudden and that the most likely causes of sudden death are lethal ventricular tachyarrhythmias such as ventricular tachycardia (VT) or fibrillation (VF). How...
Kenji Yamashiro, Kenji Yamashiro, Kenji Yamashiro, Tetsuo Sasano, Katsuyoshi Tojo, Iyuki Namekata, Junko Kurokawa, Naoki Sawada, Naoki Sawada, Takayoshi Suganami, Yasutomi Kamei, Hikaru Tanaka, Naoko Tajima, Kazunori Utsunomiya, Yoshihiro Ogawa, Yoshihiro Ogawa, Tetsushi Furukawa
Biochemical and Biophysical Research Communications   398 284-289   2010年7月   [査読有り]
There is considerable evidence indicating that intracellular Ca 2+ participates as a second messenger in TLR4-dependent signaling. However, how intracellular free Ca 2+ concentrations ([Ca 2+ ] i ) is increased in response to LPS and how they af...
Pei Chi Yang, Junko Kurokawa, Tetsushi Furukawa, Colleen E. Clancy
PLoS Computational Biology   6    2010年1月   [査読有り]
Acute effects of sex steroid hormones likely contribute to the observation that post-pubescent males have shorter QT intervals than females. However, the specific role for hormones in modulating cardiac electrophysiological parameters and arrhythm...
Asami Kaihara, Akihiko Sunami, Junko Kurokawa, Tetsushi Furukawa
Journal of the American Chemical Society   131 4188-4189   2009年4月   [査読有り]
We have developed a genetically encoded bioluminescent indicator for the Na + channel, in which Na + -sensitive Gaussia luciferase is fused with the voltage-gated Na + channel. This indicator is capable of detecting Na + flow through the pores ...
Ken Asada, Junko Kurokawa, Tetsushi Furukawa
Journal of Biological Chemistry   284 6014-6020   2009年2月   [査読有り]
Nitric oxide (NO) is a gaseous signal mediator showing numerous important biological effects. NO has been shown in many instances to exhibit its action via the protein S-nitrosylation mechanism, in which binding of NO to Cys residues regulate prot...
Shoko Kakusaka, Shoko Kakusaka, Mahoko Asayama, Mahoko Asayama, Asami Kaihara, Tetsuo Sasano, Takeshi Suzuki, Junko Kurokawa, Tetsushi Furukawa
Journal of Pharmacological Sciences   109 152-156   2009年1月   [査読有り]
We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K + currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogen...
Junko Kurokawa, Junko Kurokawa, Junko Kurokawa, John R. Bankston, Asami Kaihara, Lei Chen, Tetsushi Furukawa, Robert S. Kass
Channels   3 16-24   2009年1月   [査読有り]
Co-assembly of KCNQ1 with different accessory, or beta, subunits that are members of the KCNE family results in potassium (K + ) channels that conduct functionally distinct currents. The alpha subunit KCNQ1 conducts a slowly activated delayed rect...
Junko Kurokawa, Masaji Tamagawa, Nobuhiro Harada, Shin Ichiro Honda, Chang Xi Bai, Haruaki Nakaya, Tetsushi Furukawa
Journal of Physiology   586 2961-2973   2008年6月   [査読有り]
Female gender is a risk factor for drug-induced arrhythmias associated with QT prolongation, which results mostly from blockade of the human ether-a-go-go-related gene (hERG) channel. Some clinical evidence suggests that oestrogen is a determinant...
Hiroaki Nakamura, Hiroaki Nakamura, Junko Kurokawa, Chang Xi Bai, Ken Asada, Jun Xu, Ronit V. Oren, Zheng I. Zhu, Colleen E. Clancy, Mitsuaki Isobe, Tetsushi Furukawa, Tetsushi Furukawa
Circulation   116 2913-2922   2007年12月   [査読有り]
BACKGROUND - Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence sugg...
Yoshinori Tani, Yoshinori Tani, Daiji Miura, Junko Kurokawa, Kazufumi Nakamura, Mamoru Ouchida, Kenji Shimizu, Tohru Ohe, Tetsushi Furukawa
Journal of Molecular and Cellular Cardiology   43 187-196   2007年8月   [査読有り]
Andersen-Tawil syndrome (ATS) is a multisystem inherited disease exhibiting periodic paralysis, cardiac arrhythmias, and dysmorphic features. In this study, we characterized the KCNJ2 channels with an ATS mutation (T75M) which is associated with c...
Hiroshi Asaoka, Hiroshi Asaoka, Junko Kurokawa, Tetsushi Furukawa, Kentaro Shimokado, Kentaro Shimokado
Journal of Medical and Dental Sciences   54 97-102   2007年3月   [査読有り]
Transient alkalization caused by activation of the BK Ca channels has been reported to be essential for the activation of proteolytic enzymes and bacterial killing in the leukocytic phagosomes. We investigated the effects of high glucose concentr...
Tetsushi Furukawa, Tetsushi Furukawa, Chang Xi Bai, Asami Kaihara, Eri Ozaki, Takashi Kawano, Yutaka Nakaya, Muhammad Awais, Moritoshi Sato, Yoshio Umezawa, Junko Kurokawa
Molecular Pharmacology   70 1916-1924   2006年11月   [査読有り]
Ginseng root is one of the most popular herbs throughout the world and is believed to be a panacea and to promote longevity. It has been used as a medicine to protect against cardiac ischemia, a major cause of death in the West. We have previously...
Lei Chen, Junko Kurokawa, Robert S. Kass, Robert S. Kass
Journal of Biological Chemistry   280 31347-31352   2005年9月   [査読有り]
Regulation of the heart by the sympathetic nervous system, fundamental to the physiological response to stress and exercise, requires coordinated phosphorylation of multiple downstream molecular targets, including the I Ks (slowly activating pot...
Chang Xi Bai, Junko Kurokawa, Masaji Tamagawa, Haruaki Nakaya, Tetsushi Furukawa, Tetsushi Furukawa
Circulation   112 1701-1710   2005年9月   [査読有り]
Background - Women have longer QT c intervals than men and are at greater risk for arrhythmias associated with long QT c intervals, such as drug-induced torsade de pointes. Recent clinical and experimental data suggest an important role of testo...
Liat Shushi, Batsheva Kerem, Maya Goldmit, Asher Peretz, Bernard Attali, Aron Medina, Jeffrey A. Towbin, Junko Kurokawa, Robert S. Kass, Jesaia Benhorin, Jesaia Benhorin
Annals of Noninvasive Electrocardiology   10 334-341   2005年7月   [査読有り]
Objectives: T o describe the clinical, genetic, and electrophysiologic characteristics of a new PAS-domain HERG mutation (M124R) that has been identified in a single large Jewish family with Long QT syndrome (LQTS). Background: Many previously rep...
Chang Xi Bai, Iyuki Namekata, Junko Kurokawa, Hikaru Tanaka, Koki Shigenobu, Tetsushi Furukawa, Tetsushi Furukawa
Circulation Research   96 64-72   2005年1月   [査読有り]
Sarcolemmal Ca 2+ entry is a vital step for contraction of cardiomyocytes, but Ca 2+ overload is harmful and may trigger arrhythmias and/or apoptosis. To maintain the amount of Ca 2+ entry within an appropriate range, cardiomyocytes have feedba...
Junko Kurokawa, Howard K. Motoike, Jenny Rao, Robert S. Kass
Proceedings of the National Academy of Sciences of the United States of America   101 16374-16378   2004年11月
A-kinase anchoring proteins (AKAPs) are thought to be passive members of protein complexes that coordinate the association of cAMP-dependent protein kinase A (PKA) with cellular substrates to facilitate targeted PKA protein phosphorylation. I KS ,...
Keith W. Dilly, Junko Kurokawa, Cecile Terrenoire, Steven Reiken, W. J. Lederer, Andrew R. Marks, Robert S. Kass, Robert S. Kass
Journal of Biological Chemistry   279 40778-40787   2004年9月   [査読有り]
The cardiac slow delayed rectifier potassium channel (I Ks ), comprised of a (KCNQ1) and β (KCNE1) subunits, is regulated by sympathetic nervous stimulation, with activation of β-adrenergic receptors PKA phosphorylating I Ks channels. We examined...
M. Tateyama, J. Kurokawa, C. Terrenoire, I. Rivolta, Robert S. Kass
Circulation   107 3216-3222   2003年7月   [査読有り]
Background - Mutations in SCN5A, the gene coding for the human cardiac Na + channel α-subunit, are associated with variant 3 of the long-QT syndrome (LQT-3). Several LQT-3 mutations promote a mode of Na + channel gating in which a fraction of ch...
Junko Kurokawa, Lei Chen, Robert S. Kass
Proceedings of the National Academy of Sciences of the United States of America   100 2122-2127   2003年2月   [査読有り]
β-Adrenergic receptor stimulation increases heart rate and shortens ventricular action-potential duration, the latter effect due in part to a cAMP-dependent increase in the slow outward potassium current (I Ks ). Mutations in either KCNQ1 or KCNE1...
Christine Chiello Tracy, Candido Cabo, James Coromilas, Junko Kurokawa, Robert S. Kass, Robert S. Kass, Andrew L. Wit, Andrew L. Wit
American Journal of Physiology - Heart and Circulatory Physiology   284    2003年1月   [査読有り]
We expressed human delayed rectifier K + cardiac current (I Ks ) channels in the murine heart, which lacks native I Ks , to determine their electrophysiological role. Mice expressing human I Ks channels were anesthetized, and an electrocardiogra...
Steven O. Marx, Junko Kurokawa, Steven Reiken, Howard Motoike, Jeanine D'Armiento, Andrew R. Marks, Robert S. Kass
Science   295 496-499   2002年1月
Sympathetic nervous system (SNS) regulation of cardiac action potential duration (APD) is mediated by β adrenergic receptor (βAR) activation, which increases the slow outward potassium ion current (I KS ). Mutations in two human I KS channel subu...
J. Kurokawa, H. K. Motoike, R. S. Kass, R. S. Kass
Journal of General Physiology   117 43-52   2001年1月   [査読有り]
I Ks , a slowly activating delayed rectifier K + current through channels formed by the assembly of two subunits KCNQ1 (KvLQT1) and KCNE1 (minK), contributes to the control of the cardiac action potential duration. Coassembly of the two subunits ...
Junko Kurokawa, Satomi Adachi-Akahane, Taku Nagao
European Journal of Pharmacology   325 229-236   1997年5月   [査読有り]
The effects of a 1,5-benzothiazepine derivative, (+)-cis-3-(acetyloxy)-5-[2-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino] ethyl] -2,3- dihydro-2-(4-methyoxyphenyl)-1,5-benzothiazepine-4(5H)-one (DTZ323), on membrane currents were investigated in gu...
Junko Kurokawa, Satomi Adachi-Akahane, Taku Nagao
Molecular Pharmacology   51 262-268   1997年2月   [査読有り]
To determine whether 1,5-benzothiazepine Ca 2+ channel blocker approaches its binding domain within the cardiac L-type Ca 2+ channel from inside or outside of the membrane, we tested the effects of a novel potent 1,5-benzothiazepine derivative (...
Shoichi Kanda, Junko Kurokawa, Satomi Adachi-Akahane, Taku Nagao
European Journal of Pharmacology   319 101-107   1997年1月   [査読有り]
To examine whether the modulation of the 1,4-dihydropyridine-binding by diltiazem derivatives, which has been shown in cardiac and skeletal muscle membranes, takes place in intact cardiac myocytes, effects of diltiazem derivatives on the specific ...

Misc

 
黒川 洵子, 三枝 香都貴, 山崎 泰広
Labio 21 = ラビオ   (68) 14-17   2017年4月
黒川 洵子
ファルマシア   53(8) 796-800   2017年
本稿では、性差医学の観点から男女の違いに応じた薬物療法に関わるトピックを概説する。細胞レベルでも性差があることも分かってきたので、その病態生理学的役割の解明へ向けた取り組みも紹介する。
Junko Kurokawa, Masami Kodama, Colleen E. Clancy, Tetsushi Furukawa
Pharmacology and Therapeutics   168 23-28   2016年12月   [査読有り][依頼有り]
© 2016 Elsevier Inc. Female sex is an independent risk factor for development of torsade de pointes (TdP) arrhythmias not only in congenital long QT syndromes but also in acquired long QT syndromes. Clinical and experimental evidences suggest that...
Yasunari Kanda, Yasunari Kanda, Daiju Yamazaki, Daiju Yamazaki, Junko Kurokawa, Junko Kurokawa, Takashi Inutsuka, Takashi Inutsuka, Yuko Sekino, Yuko Sekino
Journal of Pharmacological and Toxicological Methods   81 196-200   2016年9月   [査読有り][依頼有り]
© 2016 The Authors Human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) provide a novel assay system to assess cardiac safety in drug development to overcome a problem of species difference in non-clinical testing during drug deve...
Furukawa T, Kurokawa J, Bai CX
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   147(3) 152-156   2016年3月   [査読有り]

書籍等出版物

 
iPS細胞の安全・高品質な作製技術
黒川 洵子 (担当:分担執筆, 範囲:第3章5節 ヒトiPS細胞を用いた医薬品の心毒性評価)
技術情報協会   2016年   
不整脈2015
黒川 洵子 (担当:分担執筆, 範囲:iPS細胞を用いた抗不整脈薬の心毒性評価)
メディカルレビュー社   2015年   
Molecular Mechanisms of Cardiac Remodeling
黒川 洵子 (担当:分担執筆, 範囲:Remodeling of potassium channels in cardiac hypertrophy)
Springer   2013年   
Cardiac Electrophysiology from Cell to Bedside
黒川 洵子 (担当:分担執筆, 範囲:Chapter 18: KCNQ1/KCNE1 macromolecular signaling complex: channel microdomains and human disease.)
Saunders   2009年   
QT間隔の診かた・考えかた
黒川 洵子 (担当:分担執筆, 範囲:5章 性ホルモンとイオン電流)
2007年   

講演・口頭発表等

 
男女別に進める健康長寿づくり~循環器病対策を中心に~
黒川 洵子
平成30年度静岡県立大学公開講座   2018年9月22日   
心毒性の性差
黒川 洵子
日本毒性学会年会   2018年7月20日   
動きベクトル解析によるヒトiPS細胞由来心筋細胞のモーションイメージング
黒川洵子、山口賢彦、坂本多穗
平成30年度生理研研究会「生体界面研究会」   2018年7月13日   
Ion channels in iPS-derived cardiomyocytes. [招待有り]
黒川 洵子
KYOTO Satellite Symposia New Insights into Ion Channel Functions and Pharmacology   2018年7月8日   
Electrophysiological maturation of human iPS-derived cardiomyocyte. [招待有り]
黒川 洵子
国際心血管薬物療法学会   2018年5月26日   

担当経験のある科目

 
 

競争的資金等の研究課題

 
動きベクトル解析によるヒトiPS細胞由来心筋細胞の部位特異的性質の非侵襲的識別
日本学術振興会: 科学研究費補助金、挑戦的研究(萌芽)
研究期間: 2017年4月 - 2020年3月    代表者: 黒川 洵子
薬物誘発性不整脈に関する機能解析および発症予測へ向けた統合的評価法の構築
日本学術振興会: 科学研究費補助金、基盤研究(B)
研究期間: 2015年4月 - 2019年3月    代表者: 黒川 洵子
ヒトiPS分化細胞技術を活用した医薬品の次世代毒性・安全性評価試験系の開発と国際標準化に関する研究
内閣府: AMED委託費(医薬品等規制調和・評価研究事業)
研究期間: 2015年4月 - 2018年3月    代表者: 諫田 泰成
ヒトiPS細胞由来心筋細胞株を成人心筋に橋渡しするためのインシリコツールの開発
厚生労働省、内閣府: 厚生労働科学研究費(AMED)委託費(医薬品等規制調和・評価研究事業)
研究期間: 2014年4月 - 2017年3月    代表者: 黒川 洵子
ヒトiPS分化細胞を利用した医薬品のヒト特異的有害反応評価系の開発・標準化
厚生労働省: 厚生労働科学研究費補助金(医薬品等規制調和・評価研究事業)
研究期間: 2014年4月 - 2015年3月    代表者: 関野 祐子