KUROKAWA, Junko

J-GLOBAL         Last updated: Sep 27, 2018 at 18:16
 
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Name
KUROKAWA, Junko
E-mail
junkokurou-shizuoka-ken.ac.jp
URL
http://w3pharm.u-shizuoka-ken.ac.jp/rinsho/
Affiliation
University of Shizuoka
Section
School of Pharmaceutical Sciences
Job title
Professor
Degree
PhD(University of Tokyo)
Research funding number
40396982
ORCID ID
0000-0002-9098-0908

Research Areas

 
 

Academic & Professional Experience

 
Nov 2016
 - 
Today
Professor, School of Pharmaceutical Sciences, University of Shizuoka
 
Jul 2006
 - 
Oct 2016
Associate Professor, Medical Research Institute, Tokyo Medical and Dental University
 
Sep 2004
 - 
Jun 2006
Assistant Professor, Medical Research Institute, Tokyo Medical and Dental University
 
Jul 2003
 - 
Aug 2004
Postdoctoral fellow, JSPS
 
Jul 2003
 - 
Aug 2004
Associate Research Scientist, P&S, Columbia University
 

Education

 
1995
 - 
1998
PhD, Pharmaceutical Sciences, University of Tokyo, Graduate School
 
1993
 - 
1995
MS, Pharmaceutical Sciences, University of Tokyo, Graduate School
 
1989
 - 
1993
Pharmaceutical Sciences, University of Tokyo
 

Published Papers

 
Okada JI, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T
British journal of pharmacology   175(17) 3435-3452   Sep 2018   [Refereed]
Miyamoto K, Akiyama M, Tamura F, Isomi M, Yamakawa H, Sadahiro T, Muraoka N, Kojima H, Haginiwa S, Kurotsu S, Tani H, Wang L, Qian L, Inoue M, Ide Y, Kurokawa J, Yamamoto T, Seki T, Aeba R, Yamagishi H, Fukuda K, Ieda M
Cell stem cell      Dec 2017   [Refereed]
Pei Chi Yang, Laura L. Perissinotti, Fernando López-Redondo, Yibo Wang, Kevin R. DeMarco, Mao Tsuen Jeng, Igor Vorobyov, Robert D. Harvey, Junko Kurokawa, Junko Kurokawa, Sergei Y. Noskov, Colleen E. Clancy
Journal of Physiology   595 4695-4723   Jul 2017   [Refereed]
© 2017 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society Key points: This study represents a first step toward predicting mechanisms of sex-based arrhythmias that may lead to importa...
Min Li, Yasunari Kanda, Takashi Ashihara, Tetsuo Sasano, Yuji Nakai, Masami Kodama, Erina Hayashi, Yuko Sekino, Yuko Sekino, Tetsushi Furukawa, Junko Kurokawa, Junko Kurokawa
Journal of Pharmacological Sciences   134 75-85   Jun 2017   [Refereed]
© 2017 The Authors Human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes hold great potentials to predict pro-arrhythmic risks in preclinical cardiac safety screening, although the hiPSC cardiomyocytes exhibit rather immature function...
Kodama M, Kurokawa J
Annals of translational medicine   5(4) 88   Feb 2017   [Refereed]
Shugo Tohyama, Shugo Tohyama, Jun Fujita, Chihana Fujita, Miho Yamaguchi, Sayaka Kanaami, Rei Ohno, Kazuho Sakamoto, Kazuho Sakamoto, Masami Kodama, Junko Kurokawa, Hideaki Kanazawa, Tomohisa Seki, Yoshikazu Kishino, Marina Okada, Kazuaki Nakajima, Sho Tanosaki, Shota Someya, Akinori Hirano, Shinji Kawaguchi, Eiji Kobayashi, Keiichi Fukuda
Stem Cell Reports      Jan 2017   [Refereed]
© 2017 The Author(s). Cardiac regenerative therapies utilizing human induced pluripotent stem cells (hiPSCs) are hampered by ineffective large-scale culture. hiPSCs were cultured in multilayer culture plates (CPs) with active gas ventilation (AGV)...
Shinichiro Okata, Shinichiro Okata, Shinsuke Yuasa, Tomoyuki Suzuki, Tomoyuki Suzuki, Shogo Ito, Naomasa Makita, Tetsu Yoshida, Min Li, Junko Kurokawa, Tomohisa Seki, Toru Egashira, Yoshiyasu Aizawa, Masaki Kodaira, Chikaaki Motoda, Gakuto Yozu, Masaya Shimojima, Nozomi Hayashiji, Hisayuki Hashimoto, Yusuke Kuroda, Yusuke Kuroda, Atsushi Tanaka, Mitsushige Murata, Mitsushige Murata, Takeshi Aiba, Wataru Shimizu, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Tetsushi Furukawa, Keiichi Fukuda
Scientific Reports   6    Sep 2016   [Refereed]
© The Author(s) 2016. SCN5A is abundant in heart and has a major role in I Na. Loss-of-function mutation in SCN5A results in Brugada syndrome (BrS), which causes sudden death in adults. It remains unclear why disease phenotype does not manifest in...
Kanda Y, Ashihara T, Kurokawa J
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   147(6) 334-338   Jun 2016   [Refereed]
Fernando López-Redondo, Junko Kurokawa, Fumimasa Nomura, Tomoyuki Kaneko, Tomoyo Hamada, Tetsushi Furukawa, Kenji Yasuda
Journal of Pharmacological Sciences   131 141-145   Jun 2016   [Refereed]
© 2016 The Authors We investigated electrophysiological properties of human induced-pluripotent-stem-cell-derived and embryonic-stem-cell-derived cardiomyocytes, and analyzed action potential parameters by plotting their frequency distributions. I...
Takahashi K, Sasano T, Sugiyama K, Kurokawa J, Tamura N, Soejima Y, Sawabe M, Isobe M, Furukawa T
Journal of molecular and cellular cardiology   90 38-46   Jan 2016   [Refereed]
Nagamori S, Wiriyasermkul P, Guarch ME, Okuyama H, Nakagomi S, Tadagaki K, Nishinaka Y, Bodoy S, Takafuji K, Okuda S, Kurokawa J, Ohgaki R, Nunes V, Palacín M, Kanai Y
Proceedings of the National Academy of Sciences of the United States of America   113(3) 775-780   Jan 2016   [Refereed]
Koji Sugiyama, Koji Sugiyama, Tetsuo Sasano, Tetsuo Sasano, Tetsuo Sasano, Junko Kurokawa, Kentaro Takahashi, Kentaro Takahashi, Tadashi Okamura, Tadashi Okamura, Norihiro Kato, Mitsuaki Isobe, Tetsushi Furukawa
International Heart Journal   57(3) 341-349   Jan 2016   [Refereed]
© 2016, International Heart Journal Association. All rights reserved. Genome-wide association study has identified that the genetic variations at NOS1AP (neuronal nitric oxide syn-thase-1 adaptor protein) were associated with QT interval and sudde...
Morita Y, Andersen P, Hotta A, Sasagawa N, Kurokawa J, Tsukahara Y, Hayashida N, Koga C, Nishikawa M, Evans SM, Furukawa T, Koshiba-Takeuchi K, Nishinakamura R, Yoshida Y, Kwon C, Takeuchi JK
Journal of Molecular Cellular Cardiology   92 158-162   2016   [Refereed]
Yamakawa H, Muraoka N, Miyamoto K, Sadahiro T, Isomi M, Haginiwa S, Kojima H, Umei T, Akiyama M, Kuishi Y, Kurokawa J, Furukawa T, Fukuda K, Ieda M
Stem cell reports   5(6) 1128-1142   Dec 2015   [Refereed]
Okada J, Yoshinaga T, Kurokawa J, Washio T, Furukawa T, Sawada K, Sugiura S, Hisada T
Science advances   1(4) e1400142   May 2015   [Refereed]
Junko Kurokawa, Tetsuo Sasano, Masami Kodama, Min Li, Yusuke Ebana, Nobuhiro Harada, Shin Ichiro Honda, Haruaki Nakaya, Tetsushi Furukawa
Journal of Toxicological Sciences   40 339-348   Jan 2015   [Refereed]
© 2015, Japanese Society of Toxicology. All rights reserved. Our in vitro characterization showed that physiological concentrations of estrogen partially suppressed the IKr channel current in guinea pig ventricular myocytes and the human ether-a-g...
Saito Y, Nakamura K, Yoshida M, Sugiyama H, Ohe T, Kurokawa J, Furukawa T, Takano M, Nagase S, Morita H, Kusano KF, Ito H
PloS one   10(9) e0138193   2015   [Refereed]
Mahoko Asayama, Mahoko Asayama, Junko Kurokawa, Kiyoshi Shirakawa, Hisashi Okuyama, Toshiki Kagawa, Jun Ichi Okada, Seiryo Sugiura, Toshiaki Hisada, Tetsushi Furukawa
Journal of Pharmacological Sciences   121 1-8   Feb 2013   [Refereed]
In short QT syndrome, inherited gain-of-function mutations in the human ether a-go-go-related gene (hERG) K + channel have been associated with development of fatal arrhythmias. This implies that drugs that activate hERG as a side effect may like...
Hayakawa Tomohiro, Kunihiro Takeshi, Ando Tomoko, Uno Hatsume, Kobayashi Seiji, Matsui Eriko, Yada Hiroaki, Kanda Yasunari, Kurokawa Junko, Furukawa Tetsushi
Journal of Pharmacological and Toxicological Methods   68(1) E24   2013   [Refereed]
Toru Egashira, Shinsuke Yuasa, Shinsuke Yuasa, Tomoyuki Suzuki, Tomoyuki Suzuki, Yoshiyasu Aizawa, Hiroyuki Yamakawa, Tomohiro Matsuhashi, Yohei Ohno, Shugo Tohyama, Shinichiro Okata, Tomohisa Seki, Yusuke Kuroda, Yusuke Kuroda, Kojiro Yae, Hisayuki Hashimoto, Tomofumi Tanaka, Tomofumi Tanaka, Fumiyuki Hattori, Fumiyuki Hattori, Toshiaki Sato, Shunichiro Miyoshi, Seiji Takatsuki, Mitsushige Murata, Mitsushige Murata, Junko Kurokawa, Tetsushi Furukawa, Naomasa Makita, Takeshi Aiba, Wataru Shimizu, Minoru Horie, Kaichiro Kamiya, Itsuo Kodama, Satoshi Ogawa, Keiichi Fukuda
Cardiovascular Research   95 419-429   Sep 2012   [Refereed]
Aims Long QT syndrome (LQTS) is an inheritable and life-threatening disease; however, it is often difficult to determine disease characteristics in sporadic cases with novel mutations, and more precise analysis is necessary for the successful deve...
Hiroki Sugiyama, Kazufumi Nakamura, Hiroshi Morita, Hiroshi Morita, Satoshi Akagi, Yoshinori Tani, Yusuke Katayama, Nobuhiro Nishii, Toru Miyoshi, Toru Miyoshi, Satoshi Nagase, Kunihisa Kohno, Kengo Fukushima Kusano, Tohru Ohe, Junko Kurokawa, Tetsushi Furukawa, Hiroshi Ito
PLoS ONE   6    May 2011   [Refereed]
Background: It is estimated that approximately half of the deaths in patients with HF are sudden and that the most likely causes of sudden death are lethal ventricular tachyarrhythmias such as ventricular tachycardia (VT) or fibrillation (VF). How...
Kenji Yamashiro, Kenji Yamashiro, Kenji Yamashiro, Tetsuo Sasano, Katsuyoshi Tojo, Iyuki Namekata, Junko Kurokawa, Naoki Sawada, Naoki Sawada, Takayoshi Suganami, Yasutomi Kamei, Hikaru Tanaka, Naoko Tajima, Kazunori Utsunomiya, Yoshihiro Ogawa, Yoshihiro Ogawa, Tetsushi Furukawa
Biochemical and Biophysical Research Communications   398 284-289   Jul 2010   [Refereed]
There is considerable evidence indicating that intracellular Ca 2+ participates as a second messenger in TLR4-dependent signaling. However, how intracellular free Ca 2+ concentrations ([Ca 2+ ] i ) is increased in response to LPS and how they af...
Pei Chi Yang, Junko Kurokawa, Tetsushi Furukawa, Colleen E. Clancy
PLoS Computational Biology   6    Jan 2010   [Refereed]
Acute effects of sex steroid hormones likely contribute to the observation that post-pubescent males have shorter QT intervals than females. However, the specific role for hormones in modulating cardiac electrophysiological parameters and arrhythm...
Asami Kaihara, Akihiko Sunami, Junko Kurokawa, Tetsushi Furukawa
Journal of the American Chemical Society   131 4188-4189   Apr 2009   [Refereed]
We have developed a genetically encoded bioluminescent indicator for the Na + channel, in which Na + -sensitive Gaussia luciferase is fused with the voltage-gated Na + channel. This indicator is capable of detecting Na + flow through the pores ...
Ken Asada, Junko Kurokawa, Tetsushi Furukawa
Journal of Biological Chemistry   284 6014-6020   Feb 2009   [Refereed]
Nitric oxide (NO) is a gaseous signal mediator showing numerous important biological effects. NO has been shown in many instances to exhibit its action via the protein S-nitrosylation mechanism, in which binding of NO to Cys residues regulate prot...
Shoko Kakusaka, Shoko Kakusaka, Mahoko Asayama, Mahoko Asayama, Asami Kaihara, Tetsuo Sasano, Takeshi Suzuki, Junko Kurokawa, Tetsushi Furukawa
Journal of Pharmacological Sciences   109 152-156   Jan 2009   [Refereed]
We recently reported that physiological concentrations of 17β-estradiol partially down-regulate cardiac rapidly-activating delayed rectifier K + currents (hERG currents) independently of estrogen-receptor signaling. To determine if other estrogen...
Junko Kurokawa, Junko Kurokawa, Junko Kurokawa, John R. Bankston, Asami Kaihara, Lei Chen, Tetsushi Furukawa, Robert S. Kass
Channels   3 16-24   Jan 2009   [Refereed]
Co-assembly of KCNQ1 with different accessory, or beta, subunits that are members of the KCNE family results in potassium (K + ) channels that conduct functionally distinct currents. The alpha subunit KCNQ1 conducts a slowly activated delayed rect...
Junko Kurokawa, Masaji Tamagawa, Nobuhiro Harada, Shin Ichiro Honda, Chang Xi Bai, Haruaki Nakaya, Tetsushi Furukawa
Journal of Physiology   586 2961-2973   Jun 2008   [Refereed]
Female gender is a risk factor for drug-induced arrhythmias associated with QT prolongation, which results mostly from blockade of the human ether-a-go-go-related gene (hERG) channel. Some clinical evidence suggests that oestrogen is a determinant...
Hiroaki Nakamura, Hiroaki Nakamura, Junko Kurokawa, Chang Xi Bai, Ken Asada, Jun Xu, Ronit V. Oren, Zheng I. Zhu, Colleen E. Clancy, Mitsuaki Isobe, Tetsushi Furukawa, Tetsushi Furukawa
Circulation   116 2913-2922   Dec 2007   [Refereed]
BACKGROUND - Female sex is an independent risk factor for torsade de pointes in long-QT syndrome. In women, QT interval and torsade de pointes risk fluctuate dynamically during the menstrual cycle and pregnancy. Accumulating clinical evidence sugg...
Yoshinori Tani, Yoshinori Tani, Daiji Miura, Junko Kurokawa, Kazufumi Nakamura, Mamoru Ouchida, Kenji Shimizu, Tohru Ohe, Tetsushi Furukawa
Journal of Molecular and Cellular Cardiology   43 187-196   Aug 2007   [Refereed]
Andersen-Tawil syndrome (ATS) is a multisystem inherited disease exhibiting periodic paralysis, cardiac arrhythmias, and dysmorphic features. In this study, we characterized the KCNJ2 channels with an ATS mutation (T75M) which is associated with c...
Hiroshi Asaoka, Hiroshi Asaoka, Junko Kurokawa, Tetsushi Furukawa, Kentaro Shimokado, Kentaro Shimokado
Journal of Medical and Dental Sciences   54 97-102   Mar 2007   [Refereed]
Transient alkalization caused by activation of the BK Ca channels has been reported to be essential for the activation of proteolytic enzymes and bacterial killing in the leukocytic phagosomes. We investigated the effects of high glucose concentr...
Tetsushi Furukawa, Tetsushi Furukawa, Chang Xi Bai, Asami Kaihara, Eri Ozaki, Takashi Kawano, Yutaka Nakaya, Muhammad Awais, Moritoshi Sato, Yoshio Umezawa, Junko Kurokawa
Molecular Pharmacology   70 1916-1924   Nov 2006   [Refereed]
Ginseng root is one of the most popular herbs throughout the world and is believed to be a panacea and to promote longevity. It has been used as a medicine to protect against cardiac ischemia, a major cause of death in the West. We have previously...
Lei Chen, Junko Kurokawa, Robert S. Kass, Robert S. Kass
Journal of Biological Chemistry   280 31347-31352   Sep 2005   [Refereed]
Regulation of the heart by the sympathetic nervous system, fundamental to the physiological response to stress and exercise, requires coordinated phosphorylation of multiple downstream molecular targets, including the I Ks (slowly activating pot...
Chang Xi Bai, Junko Kurokawa, Masaji Tamagawa, Haruaki Nakaya, Tetsushi Furukawa, Tetsushi Furukawa
Circulation   112 1701-1710   Sep 2005   [Refereed]
Background - Women have longer QT c intervals than men and are at greater risk for arrhythmias associated with long QT c intervals, such as drug-induced torsade de pointes. Recent clinical and experimental data suggest an important role of testo...
Liat Shushi, Batsheva Kerem, Maya Goldmit, Asher Peretz, Bernard Attali, Aron Medina, Jeffrey A. Towbin, Junko Kurokawa, Robert S. Kass, Jesaia Benhorin, Jesaia Benhorin
Annals of Noninvasive Electrocardiology   10 334-341   Jul 2005   [Refereed]
Objectives: T o describe the clinical, genetic, and electrophysiologic characteristics of a new PAS-domain HERG mutation (M124R) that has been identified in a single large Jewish family with Long QT syndrome (LQTS). Background: Many previously rep...
Chang Xi Bai, Iyuki Namekata, Junko Kurokawa, Hikaru Tanaka, Koki Shigenobu, Tetsushi Furukawa, Tetsushi Furukawa
Circulation Research   96 64-72   Jan 2005   [Refereed]
Sarcolemmal Ca 2+ entry is a vital step for contraction of cardiomyocytes, but Ca 2+ overload is harmful and may trigger arrhythmias and/or apoptosis. To maintain the amount of Ca 2+ entry within an appropriate range, cardiomyocytes have feedba...
Junko Kurokawa, Howard K. Motoike, Jenny Rao, Robert S. Kass
Proceedings of the National Academy of Sciences of the United States of America   101 16374-16378   Nov 2004
A-kinase anchoring proteins (AKAPs) are thought to be passive members of protein complexes that coordinate the association of cAMP-dependent protein kinase A (PKA) with cellular substrates to facilitate targeted PKA protein phosphorylation. I KS ,...
Keith W. Dilly, Junko Kurokawa, Cecile Terrenoire, Steven Reiken, W. J. Lederer, Andrew R. Marks, Robert S. Kass, Robert S. Kass
Journal of Biological Chemistry   279 40778-40787   Sep 2004   [Refereed]
The cardiac slow delayed rectifier potassium channel (I Ks ), comprised of a (KCNQ1) and β (KCNE1) subunits, is regulated by sympathetic nervous stimulation, with activation of β-adrenergic receptors PKA phosphorylating I Ks channels. We examined...
M. Tateyama, J. Kurokawa, C. Terrenoire, I. Rivolta, Robert S. Kass
Circulation   107 3216-3222   Jul 2003   [Refereed]
Background - Mutations in SCN5A, the gene coding for the human cardiac Na + channel α-subunit, are associated with variant 3 of the long-QT syndrome (LQT-3). Several LQT-3 mutations promote a mode of Na + channel gating in which a fraction of ch...
Junko Kurokawa, Lei Chen, Robert S. Kass
Proceedings of the National Academy of Sciences of the United States of America   100 2122-2127   Feb 2003   [Refereed]
β-Adrenergic receptor stimulation increases heart rate and shortens ventricular action-potential duration, the latter effect due in part to a cAMP-dependent increase in the slow outward potassium current (I Ks ). Mutations in either KCNQ1 or KCNE1...
Christine Chiello Tracy, Candido Cabo, James Coromilas, Junko Kurokawa, Robert S. Kass, Robert S. Kass, Andrew L. Wit, Andrew L. Wit
American Journal of Physiology - Heart and Circulatory Physiology   284    Jan 2003   [Refereed]
We expressed human delayed rectifier K + cardiac current (I Ks ) channels in the murine heart, which lacks native I Ks , to determine their electrophysiological role. Mice expressing human I Ks channels were anesthetized, and an electrocardiogra...
Steven O. Marx, Junko Kurokawa, Steven Reiken, Howard Motoike, Jeanine D'Armiento, Andrew R. Marks, Robert S. Kass
Science   295 496-499   Jan 2002
Sympathetic nervous system (SNS) regulation of cardiac action potential duration (APD) is mediated by β adrenergic receptor (βAR) activation, which increases the slow outward potassium ion current (I KS ). Mutations in two human I KS channel subu...
J. Kurokawa, H. K. Motoike, R. S. Kass, R. S. Kass
Journal of General Physiology   117 43-52   Jan 2001   [Refereed]
I Ks , a slowly activating delayed rectifier K + current through channels formed by the assembly of two subunits KCNQ1 (KvLQT1) and KCNE1 (minK), contributes to the control of the cardiac action potential duration. Coassembly of the two subunits ...
Junko Kurokawa, Satomi Adachi-Akahane, Taku Nagao
European Journal of Pharmacology   325 229-236   May 1997   [Refereed]
The effects of a 1,5-benzothiazepine derivative, (+)-cis-3-(acetyloxy)-5-[2-[[2-(3,4-dimethoxyphenyl)ethyl]-methylamino] ethyl] -2,3- dihydro-2-(4-methyoxyphenyl)-1,5-benzothiazepine-4(5H)-one (DTZ323), on membrane currents were investigated in gu...
Junko Kurokawa, Satomi Adachi-Akahane, Taku Nagao
Molecular Pharmacology   51 262-268   Feb 1997   [Refereed]
To determine whether 1,5-benzothiazepine Ca 2+ channel blocker approaches its binding domain within the cardiac L-type Ca 2+ channel from inside or outside of the membrane, we tested the effects of a novel potent 1,5-benzothiazepine derivative (...
Shoichi Kanda, Junko Kurokawa, Satomi Adachi-Akahane, Taku Nagao
European Journal of Pharmacology   319 101-107   Jan 1997   [Refereed]
To examine whether the modulation of the 1,4-dihydropyridine-binding by diltiazem derivatives, which has been shown in cardiac and skeletal muscle membranes, takes place in intact cardiac myocytes, effects of diltiazem derivatives on the specific ...

Misc

 
Junko Kurokawa, Masami Kodama, Colleen E. Clancy, Tetsushi Furukawa
Pharmacology and Therapeutics   168 23-28   Dec 2016   [Refereed][Invited]
© 2016 Elsevier Inc. Female sex is an independent risk factor for development of torsade de pointes (TdP) arrhythmias not only in congenital long QT syndromes but also in acquired long QT syndromes. Clinical and experimental evidences suggest that...
Yasunari Kanda, Yasunari Kanda, Daiju Yamazaki, Daiju Yamazaki, Junko Kurokawa, Junko Kurokawa, Takashi Inutsuka, Takashi Inutsuka, Yuko Sekino, Yuko Sekino
Journal of Pharmacological and Toxicological Methods   81 196-200   Sep 2016   [Refereed][Invited]
© 2016 The Authors Human induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) provide a novel assay system to assess cardiac safety in drug development to overcome a problem of species difference in non-clinical testing during drug deve...
Furukawa T, Kurokawa J, Bai CX
Nihon yakurigaku zasshi. Folia pharmacologica Japonica   147(3) 152-156   Mar 2016   [Refereed]
Takashi Ashihara, Junko Kurokawa, Yasunari Kanda, Ryo Haraguchi, Shin Inada, Kazuo Nakazawa, Minoru Horie
Transactions of Japanese Society for Medical and Biological Engineering   53 100-105   Jan 2015   [Refereed]
© 2015, Japan Soc. of Med. Electronics and Biol. Engineering. All rights reserved. Background: Recently, myocardial sheets consisting of human induced pluripotent stem cellderived cardiomyocytes (hiPSC-CM) have been used to clarify the mechanisms ...
OKADA Jun-ichi, YOSHINAGA Takashi, KUROKAWA Junko, WASHIO Takumi, FUKASE Hiroyuki, SUGIYAMA Atsushi, FURUKAWA Tetsushi, SAWADA Kohei, SUGIURA Seiryo, HISADA Toshiaki
Annual Meeting of the Japanese Society of Toxicology   42(0) S14-4   2015
創薬の際には,薬剤が心臓に与える副作用を評価する事が不可欠である.特にTorsade de Pointes (TdP)は致死性不整脈発展する可能性のある危険な不整脈であり,薬剤がTdP発生リスクに与える影響を評価する事がICH-S7B, ICH-E14により義務付けられている.TdPは一般にIkr電流の阻害によって心筋細胞に発生するEarly Afterdepolarization (EAD)が原因と考えられており,心電図QT間隔延長を正確に測定するthorough QT試験が薬剤のTdP...

Books etc

 
Molecular Mechanisms of Cardiac Remodeling
KUROKAWA, Junko (Part:Contributor, Remodeling of potassium channels in cardiac hypertrophy)
Springer   2013   
Cardiac Electrophysiology from Cell to Bedside
KUROKAWA, Junko (Part:Contributor, Chapter 18: KCNQ1/KCNE1 macromolecular signaling complex: channel microdomains and human disease.)
Saunders   2009   
Handbook of Experimental Pharmacology
KUROKAWA, Junko (Part:Contributor, AKAPs as Antiarrhythmic Targets?)
Springer-Verlag   2006   

Conference Activities & Talks

 
Ion channels in iPS-derived cardiomyocytes. [Invited]
KUROKAWA, Junko
KYOTO Satellite Symposia New Insights into Ion Channel Functions and Pharmacology   8 Jul 2018   
Electrophysiological maturation of human iPS-derived cardiomyocyte. [Invited]
KUROKAWA, Junko
26 May 2018   
Effects of sex hormones on mitochondrial potassium channels.
Kurokawa J, Sakamoto K
The 8th Congress of the International Society for Gender Medicine   14 Oct 2017   
Local control of sex hormonal signaling regulation in cardiac ion channels. [Invited]
Kurokawa J
Ion Channel Modulation Symposium   21 Jun 2017   
Localized signaling regulation of cardiac ion channels through progesterone receptor. [Invited]
KUROKAWA, Junko
The 69th Korean Physiological Society Annual meeting   

Research Grants & Projects

 
Regulation of cardiac ion channels.