論文

査読有り
2017年5月

Comparison of clinicopathological characteristics between T-cell prolymphocytic leukemia and peripheral T-cell lymphoma, not otherwise specified

EUROPEAN JOURNAL OF HAEMATOLOGY
  • Keisuke Kawamoto
  • ,
  • Hiroaki Miyoshi
  • ,
  • Eriko Yanagida
  • ,
  • Noriaki Yoshida
  • ,
  • Junichi Kiyasu
  • ,
  • Yasuji Kozai
  • ,
  • Tatsuma Morikita
  • ,
  • Takeharu Kato
  • ,
  • Hitoshi Suzushima
  • ,
  • Shinobu Tamura
  • ,
  • Tsuyoshi Muta
  • ,
  • Koji Kato
  • ,
  • Tetsuya Eto
  • ,
  • Ritsuko Seki
  • ,
  • Koji Nagafuji
  • ,
  • Hirohito Sone
  • ,
  • Jun Takizawa
  • ,
  • Masao Seto
  • ,
  • Koichi Ohshima

98
5
開始ページ
459
終了ページ
466
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1111/ejh.12856
出版者・発行元
WILEY

ObjectivesT-cell prolymphocytic leukemia (T-PLL) is a very rare, aggressive T-cell neoplasm. Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is also a highly aggressive lymphoma. These two diseases can often be confused with each other; therefore, we aimed to determine the clinical and pathological differences between T-PLL and PTCL-NOS.
MethodsWe analyzed 15 T-PLL and 91 PTCL-NOS patients and also compared clinical features between T-PLL and PTCL-NOS with leukemic presentation. Peripheral blood images and biopsy specimens were analyzed, and treatment responses were determined via imaging modalities. The clinicopathological characteristics were statistically compared.
ResultsT-PLL cells were smaller in size than those of PTCL-NOS with leukemic presentation (P=.0068); moreover, PTCL-NOS cells with leukemic presentation were smaller than those of PTCL-NOS without leukemic presentation (P=.0017). Immunophenotypic patterns in T-PLL and PTCL-NOS were similar. Five-year overall survival rates of T-PLL and all PTCL-NOS patients were 57.5% and 36.8%, respectively. No significant differences were found in clinical manifestations or prognoses; T-PLL and PTCL-NOS with leukemic presentation had essentially equivalent characteristics.
ConclusionT-PLL and PTCL-NOS may share common biological and clinical characteristics in Japanese patients.

Web of Science ® 被引用回数 : 6

リンク情報
DOI
https://doi.org/10.1111/ejh.12856
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/28129454
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000399882100005&DestApp=WOS_CPL

エクスポート
BibTeX RIS