OCHIAI KAZUHIKO

J-GLOBAL         Last updated: Sep 13, 2019 at 16:44
 
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Name
OCHIAI KAZUHIKO
Affiliation
Nippon Veterinary and Life Science University
Section
Faculty of Veterinary Science School of Veterinary Nursing and Technology
Job title
Associate Professor

Published Papers

 
Michishita M, Saito N, Nozawa S, Furumoto R, Nakagawa T, Sato T, Ochiai K, Azakami D, Katayama K, Nakahira R, Tazaki H, Machida Y, Ishiwata T
The Journal of veterinary medical science      Jul 2019   [Refereed]
Kawata R, Ii T, Hori T, Machida Y, Ochiai K, Azakami D, Ishiwata T, Michishita M
The Journal of veterinary medical science   81(2) 186-189   Feb 2019   [Refereed]
Azakami D, Saito A, Ochiai K, Ishiwata T, Takahashi K, Kaji N, Kaji D, Kaji N, Michishita M
Journal of comparative pathology   166 5-8   Jan 2019   [Refereed]
Yoshimura H, Otsuka A, Michishita M, Yamamoto M, Ashizawa M, Zushi M, Moriya M, Azakami D, Ochiai K, Matsuda Y, Ishiwata T, Kamiya S, Takahashi K
Veterinary pathology   300985818823772   Jan 2019   [Refereed]
Ochiai K, Azakami D, Morimatsu M, Hirama H, Kawakami S, Nakagawa T, Michishita M, Egusa AS, Sasaki T, Watanabe M, Omi T
Oncology reports   40(1) 488-494   May 2018   [Refereed]
Kawakami S, Ochiai K, Azakami D, Kato Y, Michishita M, Morimatsu M, Ishiguro-Oonuma T, Onozawa E, Watanabe M, Omi T
Veterinary research communications   42(1) 49-56   Dec 2017   [Refereed]
Ochiai K, Oda H, Shono S, Kato Y, Sugihara S, Nakazawa S, Azakami D, Michishita M, Onozawa E, Bonkobara M, Sako T, Shun-Ai L, Ueki H, Watanabe M, Omi T
Veterinary and comparative oncology   15(4) 1181-1186   Dec 2017   [Refereed]
Kawakami S, Ochiai K, Kato Y, Michishita M, Hirama H, Obara R, Azakami D, Watanabe M, Omi T
The Journal of veterinary medical science   80(1) 85-91   Nov 2017   [Refereed]
Xu J, Sadahira T, Kinoshita R, Li SA, Huang P, Wada K, Araki M, Ochiai K, Noguchi H, Sakaguchi M, Nasu Y, Watanabe M
Oncology letters   14(5) 5638-5642   Nov 2017   [Refereed]
Horikawa Y, Watanabe M, Sadahira T, Ariyoshi Y, Kobayashi Y, Araki M, Wada K, Ochiai K, Li SA, Nasu Y
Oncology letters   14(3) 3223-3228   Sep 2017   [Refereed]
Ishimori M, Michishita M, Yoshimura H, Azakami D, Ochiai K, Ishiwata T, Takahashi K.
Journal of Veterinary Medical Science   79(9) 1503-1506   Sep 2017   [Refereed]
Hayama SI, Tsuchiya M, Ochiai K, Nakiri S, Nakanishi S, Ishii N, Kato T, Tanaka A, Konno F, Kawamoto Y, Omi T
Scientific reports   7(1) 3528   Jun 2017   [Refereed]
Sakaguchi M, Sadahira T, Ueki H, Kinoshita R, Murata H, Yamamoto KI, Futami J, Nasu Y, Ochiai K, Kumon H, Huh NH, Watanabe M
Oncology reports   38(2) 1108-1114   Jun 2017   [Refereed]
Kato Y, Ochiai K, Kawakami S, Nakao N, Azakami D, Bonkobara M, Michishita M, Morimatsu M, Watanabe M, Omi T
BMC veterinary research   13(1) 170   Jun 2017   [Refereed]
Kishimoto TE, Yashima S, Nakahira R, Onozawa E, Azakami D, Ujike M, Ochiai K, Ishiwata T, Takahashi K, Michishita M
The Journal of veterinary medical science   79(7) 1155-1162   May 2017   [Refereed]
Michishita M, Takagi M, Kishimoto TE, Nakahira R, Nogami T, Yoshimura H, Hatakeyama H, Azakami D, Ochiai K, Takahashi K
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc   29(3) 325-330   May 2017   [Refereed]
Mori A, Watanabe M, Sadahira T, Kobayashi Y, Ariyoshi Y, Ueki H, Wada K, Ochiai K, Li SA, Nasu Y
Acta medica Okayama   71(2) 135-142   Apr 2017   [Refereed]
Nakahira R, Michishita M, Kato M, Okuno Y, Hatakeyama H, Yoshimura H, Azakami D, Ochiai K, Bonkobara M, Takahashi K
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc   29(1) 105-108   Jan 2017   [Refereed]
Kobayashi M, Saito A, Tanaka Y, Michishita M, Kobayashi M, Irimajiri M, Kaneda T, Ochiai K, Bonkobara M, Takahashi K, Hori T, Kawakami E
The Journal of veterinary medical science   79(4) 719-725   Feb 2017   [Refereed]
Omi T, Nakazawa S, Udagawa C, Tada N, Ochiai K, Chong YH, Kato Y, Mitsui H, Gin A, Oda H, Azakami D, Tamura K, Sako T, Inagaki T, Sakamoto A, Tsutsui T, Bonkobara M, Tsuchida S, Ikemoto S
PloS one   11(10) e0165000   Oct 2016   [Refereed]
Okamura H, Yoshida K, Morimoto H, Teramachi J, Ochiai K, Haneji T, Yamamoto A
Journal of clinical medicine   6(23)    Feb 2017   [Refereed]
Teramachi J, Inagaki Y, Shinohara H, Okamura H, Yang D, Ochiai K, Baba R, Morimoto H, Nagata T, Haneji T
Oral diseases   23 181-188   Oct 2016   [Refereed]
Azakami D, Onozawa E, Miyabe M, Ochiai K, Michishita M, Hirano T, Momota Y, Ishioka K, Sako T
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   78(5) 913-916   Jun 2016   [Refereed]
Ochiai K, Morimatsu M, Kato Y, Ishiguro-Oonuma T, Udagawa C, Rungsuriyawiboon O, Azakami D, Michishita M, Ariyoshi Y, Ueki H, Nasu Y, Kumon H, Watanabe M, Omi T
Oncotarget   7(3) 3283-3296   Jan 2016   [Refereed]
Kato Y, Ochiai K, Michishita M, Azakami D, Nakahira R, Morimatsu M, Ishiguro-Oonuma T, Yoshikawa Y, Kobayashi M, Bonkobara M, Kobayashi M, Takahashi K, Watanabe M, Omi T
Veterinary journal (London, England : 1997)   206(2) 143-148   Nov 2015   [Refereed]
Ishiguro-Oonuma T, Ochiai K, Hashizume K, Iwanaga T, Morimatsu M
The Japanese journal of veterinary research   63(3) 107-114   Aug 2015   [Refereed]
Yoshikawa Y, Morimatsu M, Ochiai K, Ishiguro-Oonuma T, Wada S, Orino K, Watanabe K
BMC veterinary research   11(1) 159   Jul 2015   [Refereed]
Fujio K, Watanabe M, Ueki H, Li SA, Kinoshita R, Ochiai K, Futami J, Watanabe T, Nasu Y, Kumon H
Oncology reports   33(4) 1585-1592   Apr 2015   [Refereed]
Ochiai K, Ishiguro-Oonuma T, Yoshikawa Y, Udagawa C, Kato Y, Watanabe M, Bonkobara M, Morimatsu M, Omi T
Biomedical research (Tokyo, Japan)   36(2) 155-158   2015   [Refereed]
Ishiguro-Oonuma T, Ochiai K, Hashizume K, Morimatsu M
Biomedical research (Tokyo, Japan)   36(2) 103-107   2015   [Refereed]
Udagawa C, Tada N, Asano J, Ishioka K, Ochiai K, Bonkobara M, Tsuchida S, Omi T
BMC research notes   7(1) 904   Dec 2014   [Refereed]
Tanaka T, Kasai H, Yamashita A, Okuyama-Dobashi K, Yasumoto J, Maekawa S, Enomoto N, Okamoto T, Matsuura Y, Morimatsu M, Manabe N, Ochiai K, Yamashita K, Moriishi K
Journal of virology   88(22) 13352-13366   Nov 2014   [Refereed]
Ochiai K, Hayama S, Nakiri S, Nakanishi S, Ishii N, Uno T, Kato T, Konno F, Kawamoto Y, Tsuchida S, Omi T
Scientific reports   4 5793   Jul 2014   [Refereed]
Watanabe M, Sakaguchi M, Kinoshita R, Kaku H, Ariyoshi Y, Ueki H, Tanimoto R, Ebara S, Ochiai K, Futami J, Li SA, Huang P, Nasu Y, Huh NH, Kumon H
Oncology reports   31(3) 1089-1095   Mar 2014   [Refereed]
Horiuchi N, Aihara N, Mizutani H, Kousaka S, Nagafuchi T, Ochiai M, Ochiai K, Kobayashi Y, Furuoka H, Asai T, Oishi K
The Journal of veterinary medical science / the Japanese Society of Veterinary Science   76(2) 243-248   Mar 2014   [Refereed]
Ishikawa M, Yoshida K, Okamura H, Ochiai K, Takamura H, Fujiwara N, Ozaki K
Biochimica et biophysica acta   1832(12) 2035-2043   Dec 2013   [Refereed]
Ochiai K, Watanabe M, Azakami D, Michishita M, Yoshikawa Y, Udagawa C, Metheenukul P, Chahomchuen T, Aoki H, Kumon H, Morimatsu M, Omi T
Veterinary journal (London, England : 1997)   197(3) 769-775   Sep 2013   [Refereed]
Hayama S, Nakiri S, Nakanishi S, Ishii N, Uno T, Kato T, Konno F, Kawamoto Y, Tsuchida S, Ochiai K, Omi T
PloS one   8(7) e68530   2013   [Refereed]
Yoshida K, Okamura H, Ochiai K, Hoshino Y, Haneji T, Yoshioka M, Hinode D, Yoshida H
Molecular and cellular endocrinology   361(1-2) 99-105   Sep 2012   [Refereed]
Ueki H, Watanabe M, Kaku H, Huang P, Li SA, Ochiai K, Hirata T, Noguchi H, Yamada H, Takei K, Nasu Y, Kashiwakura Y, Kumon H
International journal of oncology   41(1) 135-140   Jul 2012   [Refereed]
Yoshikawa Y, Morimatsu M, Ochiai K, Okuda K, Taoda T, Chikazawa S, Shimamura A, Omi T, Bonkobara M, Orino K, Watanabe K
BMC research notes   5 173   Apr 2012   [Refereed]
Kawauchi K, Watanabe M, Kaku H, Huang P, Sasaki K, Sakaguchi M, Ochiai K, Huh NH, Nasu Y, Kumon H
Acta medica Okayama   66(1) 7-16   Feb 2012   [Refereed]
Yoshikawa Y, Ochiai K, Morimatsu M, Suzuki Y, Wada S, Taoda T, Iwai S, Chikazawa S, Orino K, Watanabe K
PloS one   7(10) e45833   2012   [Refereed]
Ochiai K, Yoshikawa Y, Oonuma T, Tomioka Y, Hashizume K, Morimatsu M
Veterinary journal (London, England : 1997)   190(2) 293-295   Nov 2011   [Refereed]
Watanabe M, Ueki H, Ochiai K, Huang P, Kobayashi Y, Nasu Y, Sasaki K, Kaku H, Kashiwakura Y, Kumon H
Oncology reports   26(4) 769-775   Oct 2011   [Refereed]
Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H
Biochemical and biophysical research communications   412(2) 391-395   Aug 2011   [Refereed]
Ochiai K, Yoshikawa Y, Yoshimatsu K, Oonuma T, Tomioka Y, Takeda E, Arikawa J, Mominoki K, Omi T, Hashizume K, Morimatsu M
FEBS letters   585(12) 1771-1777   Jun 2011   [Refereed]
Jie Chen, Masami Watanabe, Peng Huang, Masakiyo Sakaguchi, Kazuhiko Ochiai, Yasutomo Nasu, Mamoru Ouchida, Nam Ho Huh, Kenji Shimizu, Yuji Kashiwakura, Haruki Kaku, Haruki Kaku, Hiromi Kumon, Hiromi Kumon
International Journal of Molecular Medicine   24(6) 789-794   Nov 2009
The reduced expression in immortalized cells (REIC)/Dickkopf (Dkk)-3, a member of the Dkk gene family, is a tumor suppressor in a broad range of cancers. REIC/Dkk-3 transfected stable clones of mouse prostate cancer RM9 cells (RM9-REIC) and the em...
Masakiyo Sakaguchi, Ken Kataoka, Fernando Abarzua, Fernando Abarzua, Ryuta Tanimoto, Ryuta Tanimoto, Masami Watanabe, Hitoshi Murata, Swe Swe Than, Kaoru Kurose, Yuji Kashiwakura, Kazuhiko Ochiai, Yasutomo Nasu, Hiromi Kumon, Nam Ho Huh
Journal of Biological Chemistry   284(21) 14236-14244   May 2009
We previously showed that the tumor suppressor gene REIC/Dkk-3, when overexpressed by an adenovirus (Ad-REIC), exhibited a dramatic therapeutic effect on human cancers through a mechanism triggered by endoplasmic reticulum stress. Adenovirus vecto...
Masami Watanabe, Masami Watanabe, Yuji Kashiwakura, Peng Huang, Kazuhiko Ochiai, Junichiro Futami, Shun Ai Li, Munenori Takaoka, Yasutomo Nasu, Masakiyo Sakaguchi, Nam Ho Huh, Hiromi Kumon, Hiromi Kumon
International Journal of Oncology   34(3) 657-663   Apr 2009
The REIC/Dkk-3 gene has been reported to be a tumor suppressor and the expression is significantly down-regulated in a broad range of cancer cell types. The protein is secretory, but the physiological function remains unclear. This study demonstra...
Fernando Abarzua, Yuji Kashiwakura, Munenori Takaoka, Masami Watanabe, Masami Watanabe, Kazuhiko Ochiai, Masakiyo Sakaguchi, Takao Iwawaki, Ryuta Tanimoto, Yasutomo Nasu, Yasutomo Nasu, Nam ho Huh, Hiromi Kumon, Hiromi Kumon
Biochemical and Biophysical Research Communications   375(4) 614-618   Oct 2008
Overexpression of REIC/Dkk-3 (a tumor suppressor gene) induces cancer cell apoptosis through endoplasmic reticulum (ER) stress. Therefore, the identification of the portion of REIC/Dkk-3 that causes ER stress may be essential for the development o...
Yuji Kashiwakura, Yuji Kashiwakura, Kazuhiko Ochiai, Masami Watanabe, Masami Watanabe, Fernando Abarzua, Masakiyo Sakaguchi, Munenori Takaoka, Ryuta Tanimoto, Yasutomo Nasu, Yasutomo Nasu, Nam Ho Huh, Hiromi Kumon, Hiromi Kumon
Cancer Research   ;68(20) 8333-8341   Oct 2008
REIC/Dickkopf-3 (Dkk-3), a tumor suppressor gene, has been investigated in gene therapy studies. Our previous study suggested that REIC/Dkk-3-induced apoptosis mainly resulted from phosphorylation of c-Jun-NH2 kinase (JNK) in prostate cancer cells...
Yoshikawa Y, Morimatsu M, Ochiai K, Nagano M, Tomioka Y, Sasaki N, Hashizume K, Iwanaga T
American journal of veterinary research   69(10) 1323-1328   Oct 2008   [Refereed]
K. Kawasaki, M. Watanabe, M. Watanabe, M. Sakaguchi, Y. Ogasawara, K. Ochiai, Y. Nasu, H. Doihara, H. Doihara, Y. Kashiwakura, N. H. Huh, H. Kumon, H. Kumon, H. Date
Cancer Gene Therapy   16(1) 65-72   2008
The overexpression of reduced expression in immortalized cells (REIC)/Dickkopf-3 (Dkk-3), a tumor suppressor gene, induced apoptosis in human prostatic and testicular cancer cells. The aim of this study is to examine the potential of REIC/Dkk-3 as...

Conference Activities & Talks

 
gan syoudoubutsu [Invited]
OCHIAI KAZUHIKO
16 Feb 2019   JCVIM
R132 MUTATIONS IN CANINE ISOCITRATE DEHYDROGENASE 1 (IDH1) LEAD TO FUNCTIONAL CHANGES
Kawakami S, Ochiai K, Kato Y, Azakami D, Michishita M, Omi T
XVIIIth ISACP Congress   7 Aug 2018   
ENDOGENOUS LEU332GLN MUTATION IN P53 DISRUPTS THE TETRAMERIZATION ABILITY IN THE CANINE MAMMARY GLAND TUMOR CELL LINE.
Ochiai K, Azakami D, Hirama H, Kawakami S, Uno Y, Omi T
XVIIIth ISACP Congress   7 Aug 2018   

Research Grants & Projects

 
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(C))
Project Year: 2011 - 2013    Investigator(s): Masami MORIMATSU
Mammary tumors are the most common tumor type in both human and canine females. In women, carriers of mutations in BRCA2, a tumor suppressor gene product, have a higher risk of breast cancer. Canine BRCA2 has also been suggested to have a relation...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(若手研究(B))
Project Year: 2010 - 2011    Investigator(s): Kazuhiko OCHIAI
REIC/Dkk-3 acts as a tumor suppressor in multiple cancer cell lines by inducing apoptosis through endoplasmic reticulum(ER) stress signaling. However, the intracellular interaction partners of REIC/Dkk-3 have not been fully elucidated. By employin...
Ministry of Education, Culture, Sports, Science and Technology: Grants-in-Aid for Scientific Research(基盤研究(B))
Project Year: 2008 - 2010    Investigator(s): Kozo MATSUMOTO
We developed a single congenic rat introgressed Nidd4 or Nidd6 locus responsible for the onset of diabetes in obese type 2 diabetes rat, OLETF. We chose F344 rat as the background strain. We found that both single congenic strains showed significa...