論文

査読有り
2012年8月

Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
  • Katherine J. D. A. Excoffon
  • ,
  • Abimbola O. Kolawole
  • ,
  • Nobuyoshi Kusama
  • ,
  • Nicholas D. Gansemer
  • ,
  • Priyanka Sharma
  • ,
  • Alesia M. Hruska-Hageman
  • ,
  • Elena Petroff
  • ,
  • Christopher J. Benson

425
1
開始ページ
13
終了ページ
18
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1016/j.bbrc.2012.07.033
出版者・発行元
ACADEMIC PRESS INC ELSEVIER SCIENCE

We have previously shown that the Coxsackievirus and adenovirus receptor (CAR) can interact with postsynaptic density 95 (PSD-95) and localize PSD-95 to cell-cell junctions. We have also shown that activity of the acid sensing ion channel (ASIC3), a H+-gated cation channel that plays a role in mechanosensation and pain signaling, is negatively modulated by PSD-95 through a PDZ-based interaction. We asked whether CAR and ASIC3 simultaneously interact with PSD-95, and if so, whether co-expression of these proteins alters their cellular distribution and localization. Results indicate that CAR and ASIC3 co-immunoprecipitate only when co-expressed with PSD-95. CAR also brings both PSD-95 and ASIC3 to the junctions of heterologous cells. Moreover, CAR rescues PSD-95-mediated inhibition of ASIC3 currents. These data suggest that, in addition to activity as a viral receptor and adhesion molecule, CAR can play a role in trafficking proteins, including ion channels, in a PDZ-based scaffolding complex. (C) 2012 Elsevier Inc. All rights reserved.

Web of Science ® 被引用回数 : 5

リンク情報
DOI
https://doi.org/10.1016/j.bbrc.2012.07.033
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/22809504
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000308269500003&DestApp=WOS_CPL

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