2009年8月
Synthesis of a Core Carbon Framework of Cyanosporasides A and B
JOURNAL OF ORGANIC CHEMISTRY
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- 巻
- 74
- 号
- 15
- 開始ページ
- 5590
- 終了ページ
- 5594
- 記述言語
- 英語
- 掲載種別
- DOI
- 10.1021/jo901141t
- 出版者・発行元
- AMER CHEMICAL SOC
Treatment of 3-(2-ethynylphenyl)prop-2-ynyl benzenesulfinate with 2.5-mol % of [RhCl(CO)(2)](2) at 40 degrees C under an atmosphere of CO effected the successive 2,3-sigmatropic rearrangement and carbonylative [2 + 2 + 1] ring-closing reaction to afford the 8-(phenylsulfonyl)-1H-cyclopent[a]-inden-2-one in a high yield. Chemical modification of the ring-closed product via lipase-mediated optical resolution produced tile optically active 3-acetoxy-3a-cyclohexyloxy-3,3a-dihydrocyclopent[a]indene skeleton, the core carbon framework of cyanosporasides A and B.
- リンク情報
- ID情報
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- DOI : 10.1021/jo901141t
- ISSN : 0022-3263
- PubMed ID : 19558182
- Web of Science ID : WOS:000268480300063