Yasuhiro Nonaka

Profile Information

Affiliation: Faculty of Medicine, Kagawa University

Degree: 博士（理学）(北海道大学)

ORCID ID: https://orcid.org/0000-0003-0302-5409
J-GLOBAL ID: 201001087379027390
researchmap Member ID: 6000021921

External link: http://www.kms.ac.jp/~endo/

Research Interests

Research Areas

Research History

Education

Papers

Xenopus Galectin: Molecular Function and Evolution

Takashi Ogawa, Yasuhiro Nonaka, Takanori Nakamura

Trends in Glycoscience and Glycotechnology, 35(207) E68-E72, Sep, 2023 Peer-reviewedInvited
Crystal structure and conformational stability of a galectin-1 tandem-repeat mutant with a short linker

Yasuhiro Nonaka, Takashi Ogawa, Hiroki Shoji, Nozomu Nishi, Shigehiro Kamitori, Takanori Nakamura

Glycobiology, 32(3) 251-259, Oct 27, 2021 Peer-reviewedLead author
Modulation of the carbohydrate-binding specificity of two Xenopus proto-type galectins by site-directed mutagenesis

Yasuhiro Nonaka, Takashi Ogawa, Hiroki Shoji, Nozomu Nishi, Shigehiro Kamitori, Takanori Nakamura

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1869(10) 140684-140684, Oct, 2021 Peer-reviewedLead author
Structures of human galectin-10/monosaccharide complexes demonstrate potential of monosaccharides as effectors in forming Charcot-Leyden crystals.

Aiko Itoh, Yasuhiro Nonaka, Shin-Ichi Nakakita, Hiromi Yoshida, Nozomu Nishi, Takanori Nakamura, Shigehiro Kamitori

Biochemical and biophysical research communications, 525(1) 87-93, Feb 17, 2020 Peer-reviewed
Galectin-9 induces atypical ubiquitination leading to cell death in PC-3 prostate cancer cells

Aiko Itoh, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Nozomu Nishi

Glycobiology, 29(1) 22-35, Nov, 2018 Peer-reviewed
Small leucine-rich repeat proteoglycans associated with mature insoluble elastin serve as binding sites for galectins

Aiko Itoh, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Nozomu Nishi

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 81(11) 2098-2104, 2017 Peer-reviewed
Cooperative Interactions of Oligosaccharide and Peptide Moieties of a Glycopeptide Derived from IgE with Galectin-9

Shin-ichi Nakakita, Aiko Itoh, Yukari Nakakita, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Nozomu Nishi

JOURNAL OF BIOLOGICAL CHEMISTRY, 291(2) 968-979, Jan, 2016 Peer-reviewed
Crystal structure of a Xenopus laevis skin proto-type galectin, close to but distinct from galectin-1

Yasuhiro Nonaka, Takashi Ogawa, Hiromi Yoshida, Hiroki Shoji, Nozomu Nishi, Shigehiro Kamitori, Takanori Nakamura

GLYCOBIOLOGY, 25(7) 792-803, Jul, 2015 Peer-reviewedLead author
Direct cytocidal effect of galectin-9 localized on collagen matrices on human immune cell lines

Youko Fukata, Aiko Itoh, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Osamu Matsushita, Nozomu Nishi

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS, 1840(6) 1892-1901, Jun, 2014 Peer-reviewed
Optimization of the inter-domain structure of galectin-9 for recombinant production

Aiko Itoh, Yoko Fukata, Hiroshi Miyanaka, Yasuhiro Nonaka, Takashi Ogawa, Takanori Nakamura, Nozomu Nishi

GLYCOBIOLOGY, 23(8) 920-925, Aug, 2013 Peer-reviewed
Self-association of the galectin-9 C-terminal domain via the opposite surface of the sugar-binding site

Yasuhiro Nonaka, Takashi Ogawa, Souichi Oomizu, Shin-ichi Nakakita, Nozomu Nishi, Shigehiro Kamitori, Mitsuomi Hirashima, Takanori Nakamura

The Journal of Biochemistry, 153(5) 463-471, May, 2013 Peer-reviewedLead author
STPR, a 23-Amino Acid Tandem Repeat Domain, Found in the Human Function-Unknown Protein ZNF821

Yasuhiro Nonaka, Hideki Muto, Tomoyasu Aizawa, Etsuro Okabe, Shohei Myoba, Takuya Yokoyama, Shin Saito, Fumie Tatami, Yasuhiro Kumaki, Masakatsu Kamiya …

BIOCHEMISTRY, 49(38) 8367-8375, Sep, 2010 Peer-reviewedLead author
1P083 STPR, a 23-amino-acid tandem repeat domain, found in the human function-unknown protein ZNF821(Protein:Function,The 48th Annual Meeting of the Biophysical Society of Japan)

OKABE Etsuro, NONAKA Yasuhiro, MUTO Hideki, AIZAWA Tomoyasu, MYOBA Shohei, KAMIYA Masakatsu, KIKUKAWA Takashi, TAKIYA Shigeharu, KINJO Masataka, DEMURA Makoto …

Seibutsu Butsuri, 50(2) S33-S34, 2010
X-ray crystallography and structural stability of digestive lysozyme from cow stomach

Yasuhiro Nonaka, Daisuke Akieda, Tomoyasu Aizawa, Nobuhisa Watanabe, Masakatsu Kamiya, Yasuhiro Kumaki, Mineyuki Mizuguchi, Takashi Kikukawa, Makoto Demura, Keiichi Kawano

FEBS JOURNAL, 276(8) 2192-2200, Apr, 2009 Peer-reviewedLead author
1TP5-09 DNA-binding function of the score and three amino acid peptide repeat domain in a human unknown protein(The 47th Annual Meeting of the Biophysical Society of Japan)

Nonaka Yasuhiro, Myoba Shohei, Okabe Etsuro, Muto Hideki, Kamiya Masakatsu, Kikukawa Takashi, Aizawa Tomoyasu, Kinjo Masataka, Takiya Shigeharu, Demura Makoto …

Seibutsu Butsuri, 49 S38, 2009
Spontaneous asparaginyl deamidation of canine milk lysozyme under mild conditions

Yasuhiro Nonaka, Tomoyasu Aizawa, Daisuke Akieda, Masanori Yasui, Masahiro Watanabe, Nobuhisa Watanabe, Isao Tanaka, Masakatsu Kamiya, Mineyuki Mizuguchi, Makoto Demura …

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 72(1) 313-322, Jul, 2008 Peer-reviewedLead author
1P-099 Pepsin Resistance and Conformational Stability of Mammal Digestive Lysozyme(The 46th Annual Meeting of the Biophysical Society of Japan)

Nonaka Yasuhiro, Akieda Daisuke, Watanabe Nobuhisa, Tanaka Isao, Kamiya Masakatsu, Aizawa Tomoyasu, Demura Makoto, Kawano Keiichi

Seibutsu Butsuri, 48 S36, 2008
2P022 Influence of protein structure on the adsorption of human lysozyme onto hydroxyapatite(29. Protein structure and dynamics (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)

Nodzumi Takuya, Shimamoto Satoshi, Akieda Daisuke, Nonaka Yasuhiro, Aizawa Tomoyasu, Demura Makoto, Kawano Keiichi

Seibutsu Butsuri, 46(2) S301, 2006

Misc.

Structure of human galectin-1 tandem-repeat mutant with lactose

Y. Nonaka, S. Kamitori, T. Nakamura

Mar 17, 2021 Lead author
ガレクチンの立体構造と糖鎖結合能の相関性についての解析

野中康宏, 小川崇, 東海林博樹, 吉田裕美, 西望, 神鳥成弘, 中村隆範

日本生化学会大会(Web), 91st, 2018
ガレクチン-1の糖鎖特異性および多量体構造とアポトーシス誘導活性の相関について

野中康宏, 小川崇, 吉田裕美, 東海林博樹, 西望, 神鳥成弘, 中村隆範

日本生化学会大会(Web), 90th, 2017
ヒトガレクチン-1とツメガエルガレクチン-Vaの糖鎖選択性を決める構造的要因について

野中康宏, 小川崇, 吉田裕美, 東海林博樹, 西望, 神鳥成弘, 中村隆範

日本蛋白質科学会年会プログラム・要旨集, 16th, 2016
ヒトガレクチン-1とツメガエルガレクチン-Vaの比較による,ガレクチンの構造と機能についての解析

野中康宏, 小川崇, 吉田裕美, 東海林博樹, 西望, 神鳥成弘, 中村隆範

日本生化学会大会(Web), 89th, 2016
X-ray crystal structure of Xenopus laevis galectin-Ib

Y. Nonaka, H. Yoshida, S. Kamitori, T. Nakamura

Apr 8, 2015
X-ray crystal structure of Xenopus laevis galectin-Va

Y. Nonaka, H. Yoshida, S. Kamitori, T. Nakamura

Apr 8, 2015
ツメガエル皮膚ガレクチンの構造・機能解析とgalectin-1との比較

野中康宏, 小川崇, 吉田裕美, 東海林博樹, 西望, 神鳥成弘, 中村隆範

日本蛋白質科学会年会プログラム・要旨集, 15th, 2015
ツメガエル皮膚ガレクチンの立体構造とアロステリックな挙動についての解析

野中康宏, 小川崇, 吉田裕美, 東海林博樹, 西望, 神鳥成弘, 中村隆範

日本生化学会大会(Web), 88th, 2015
アフリカツメガエルの皮膚および遍在型ガレクチンの立体構造解析

野中康宏, 吉田裕美, 小川崇, 東海林博樹, 西望, 神鳥成弘, 中村隆範

日本蛋白質科学会年会プログラム・要旨集, 14th, 2014
アフリカツメガエル皮膚由来ガレクチンの立体構造と機能の解析

野中康宏, 吉田裕美, 小川崇, 東海林博樹, 西望, 神鳥成弘, 中村隆範

日本生化学会大会(Web), 87th, 2014
Crystallographic Structure And Structural Stability Of Vertebrate Digestive Lysozyme

Yasuhiro Nonaka, Daisuke Akieda, Nobuhisa Watanabe, Masakatsu Kamiya, Tomoyasu Aizawa, Makoto Demura, Keiichi Kawano

Biophysical Journal, 96(3) 67a-68a, Feb, 2009
X-ray Crystal Structure of Bovine Stomach Lysozyme

D. Akieda, Y. Nonaka, N. Watanabe, I. Tanaka, M. Kamiya, T. Aizawa, K. Nitta, M. Demura, K. Kawano

May 27, 2008
Crystal Structure of Canine Milk Lysozyme Stabilized against Non-enzymatic Deamidation

Y. Nonaka, D. Akieda, N. Watanabe, I. Tanaka, M. Kamiya, T. Aizawa, K. Nitta, M. Demura, K. Kawano

Nov 27, 2007
2P068 Construction of mutant canine milk lysozyme stabilized against degradation for physical analysis(Proteins-stability, folding, and other physicochemical properties,Oral Presentations)

Nonaka Yasuhiro, Akieda Daisuke, Kamiya Masakatsu, Aizawa Tomoyasu, Demura Makoto, Kawano Keiichi

Biophysics, 47(1) S130, Nov 20, 2007
1P056 Overexpression and structure of canine milk lysozyme mutant in Pichia pastoris

Akieda D, Yasui M, Nonaka Y, Shimamoto S, Nodumi T, Aizawa T, Demura M, Nitta K, Kawano K

Biophysics, 45(1) S45, Oct 19, 2005
1P084 Structure formation and non-enzymatic deamidation of asparagine residus in canine milk lysozyme

Nonaka Y, Akieda D, Aizawa T, Demura M, Nitta K, Kawano K

Biophysics, 45(1) S52, Oct 19, 2005
1P001 Construction of an expression system of canine milk lysozyme in the metylotrophic yeast Pichia pastoris

Akieda D, Aizawa T, Yasui M, Nonaka Y, Watanabe M, Yamamoto H, Demura M, Kawano K, Nitta K

Biophysics, 44(1) S30, Nov 10, 2004
3P060 Contribution of the Folding Intermediates to Amyloid Fibrillation Investigated Using the Canine Milk Lysozyme Variant

Nonaka Y, Watanabe M, Aizawa T, Mizuguchi M, Demura M, Nitta K

Biophysics, 44(1) S204, Nov 10, 2004

Presentations

ウェルシュ菌線毛の宿主細胞接着部CppB-CppA共有結合複合体のクライオ電顕とX線結晶解析による立体構造解析の試み

野中康宏, 玉井栄治, 関谷洋志, 中村隆範, 神鳥成弘

第96回日本生化学会大会, Oct 31, 2023, 日本生化学会
ウェルシュ菌線毛のシャフト部タンパク質CppAと宿主接着部タンパク質CppBの連結部位を含む立体構造の解析

野中康宏, 玉井栄治, 関谷洋志, 中村隆範, 神鳥成弘

第76回日本細菌学会中国・四国支部総会, Oct 28, 2023, 日本細菌学会中国・四国支部
I型インターフェロン産生に関わる転写因子Spi-BのEtsドメイン-DNA複合体構造解析

野中康宏, 中村隆範, 星野克明, 神鳥成弘

第23回日本蛋白質科学会年会, Jul 7, 2023, 日本蛋白質科学会
Conformational stabilities of galectin-1 dimer and tandem-repeat mutant

Yasuhiro Nonaka, Takashi Ogawa, Hiroki Shoji, Nozomu Nishi, Shigehiro Kamitori, Takanori Nakamura

Nov 9, 2022
Structural and biochemical characterizations of Ovis aries and Capra hircus galectin-15

Nonaka, Yasuhiro, Nakakita, Shin-ichi, Nakamura, Takanori, Kamitori, Shigehiro

The 94th annual meeting of the Japanese Biochemical Society, Nov 3, 2021
Structural and Functional Analysis of Galectin-1 Tandem-Repeat Mutant

Sep, 2020
Comparison of Galectin-1 Wild Type Dimer and Artificially Connected Tandem-Repeat Mutant

Yasuhiro Nonaka, Takashi Ogawa, Hiroki Shoji, Nozomu Nishi, Shigehiro Kamitori, Takanori Nakamura

Jul, 2020
X-ray structures of galectin-10 complexes with monosaccharides

Yasuhiro Nonaka, Aiko Itoh, Hiromi Yoshida, Shin-Ichi Nakakita, Takanori Nakamura, Nozomu Nishi, Shigehiro Kamitori

The 92st Annual Meeting of the Japanese Biochemical Society, Sep, 2019
Analysis of galectin-1 dimer formation through intermolecular beta-sheets

NONAKA Yasuhiro

Joint Annual Meeting of 71st JSCB & 19th PSSJ, Jun, 2019
Correlation of tertiary structure and glycan specificity of galectins

NONAKA Yasuhiro

The 91st Annual Meeting of the Japanese Biochemical Society, Sep, 2018
Analysis of galectin-1 dimerization by calorimetry and spectroscopy

NONAKA Yasuhiro

The 18th Annual Meeting of the Protein Science Society of Japan, Jun, 2018
Correlation between carbohydrate-binding specificity/oligomeric structure and pro-apoptotic activity of galectin-1

Consortium of Biological Sciences 2017, Dec, 2017
ヒトガレクチン-1とツメガエルガレクチン-Vaの糖鎖選択性を決める構造的要因について

第16回日本蛋白質科学会年会, 2016
ヒトガレクチン-1とツメガエルガレクチン-Vaの比較による、ガレクチンの構造と機能についての解析

第89回日本生化学会大会, 2016
Structural factors controlling the glycan selectivities of human galectin-1 and Xenopus galectin-Va

第16回日本蛋白質科学会年会, 2016
Analyses of structures and functions of galectins by comparing human galectin-1 and Xenopus galectin-Va

第89回日本生化学会大会, 2016
ツメガエル皮膚ガレクチンの構造・機能解析とgalectin-1との比較

第15回日本蛋白質科学会年会, 2015
ツメガエル由来の二種のプロト型ガレクチンついてのX線結晶構造解析

第１４回四国免疫フォーラム, 2015
ツメガエル消化管およびヒト大腸がん細胞におけるガレクチン-4の発現及び機能解析

第38回日本分子生物学会年会、第88回日本生化学会大会合同大会, 2015
ツメガエル皮膚ガレクチンの立体構造とアロステリックな挙動についての解析

第38回日本分子生物学会年会、第88回日本生化学会大会（合同大会）, 2015

Teaching Experience

Professional Memberships

Research Projects

Small leucine-rich repeat proteoglycans associated with mature insoluble elastin serve as binding sites for galectins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2015 - Mar, 2018

Nishi Nozomu, NONAKA Yasuhiro
ガレクチン-糖鎖相互作用についての構造生物学的解析

2010
Structural analysis of Galectin-carbohydrate interaction

2010

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