2014年
Sustained efficacy of apomorphine in Japanese patients with advanced Parkinson's disease
Parkinsonism and Related Disorders
- 巻
- 20
- 号
- 8
- 開始ページ
- 819
- 終了ページ
- 823
- 記述言語
- 英語
- 掲載種別
- 研究論文(学術雑誌)
- DOI
- 10.1016/j.parkreldis.2014.04.008
- 出版者・発行元
- Elsevier Ltd
Background: This report presents data from one of the first trials of apomorphine rescue treatment for advanced Parkinson's disease (PD) conducted in Japan. This 3 month trial aimed to evaluate the sustainability of efficacy of intermittent apomorphine rescue treatment. Methods: A phase III, double-blind, placebo-controlled trial was conducted in PD patients (n=31) with motor fluctuations in spite of individually titrated treatment with levodopa and other anti PD. Intermittent treatment was titrated to the maintenance dose with a subsequent unblind 12-week outpatient phase. At the week-12 visit, response to apomorphine or placebo was assessed as primary efficacy endpoint using the Unified Parkinson's Disease Rating Scale (UPDRS) part III (Motor Examination) under double-blind crossover conditions. Results: In the crossover phase (n=28), least squares mean changes in the UPDRS part III score from pre-dose were-24.5 points with apomorphine and-2.3 points with placebo, showing that apomorphine, compared with placebo, provided a significantly greater improvement in the UPDRS part III score change (difference between treatments: -22.1 [95% confidence interval, -27.8, -16.4]
P<
0.001). The most frequently reported adverse events during the study were increased eosinophil count (8 patients), nausea (7), somnolence (6), dyskinesia (5), yawning (5), and decreased blood pressure (3). Conclusions: Our results indicate that a 3-month use of intermittent apomorphine is an effective rescue therapy for "off" episodes in advanced PD patients. © 2014 Elsevier Ltd.
P<
0.001). The most frequently reported adverse events during the study were increased eosinophil count (8 patients), nausea (7), somnolence (6), dyskinesia (5), yawning (5), and decreased blood pressure (3). Conclusions: Our results indicate that a 3-month use of intermittent apomorphine is an effective rescue therapy for "off" episodes in advanced PD patients. © 2014 Elsevier Ltd.
- リンク情報
- ID情報
-
- DOI : 10.1016/j.parkreldis.2014.04.008
- ISSN : 1873-5126
- ISSN : 1353-8020
- PubMed ID : 24792991
- SCOPUS ID : 84905241799