論文

査読有り 最終著者 責任著者 本文へのリンクあり
2015年1月

BILL-Cadherin/Cadherin-17 Contributes to the Survival of Memory B Cells

PLOS ONE
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回数 : 54
  • Shuichi Funakoshi
  • ,
  • Takeyuki Shimizu
  • ,
  • Osamu Numata
  • ,
  • Manabu Ato
  • ,
  • Fritz Melchers
  • ,
  • Kazuo Ohnishi

10
1
開始ページ
e0117566
終了ページ
記述言語
英語
掲載種別
研究論文(学術雑誌)
DOI
10.1371/journal.pone.0117566
出版者・発行元
PUBLIC LIBRARY SCIENCE

Memory B cells (MBCs) and long-lived plasma cells (LLPCs) are responsible for immunological "memory", which can last for many years. The long-term survival niche for LLPCs in the bone marrow is well characterized; however, the corresponding niche for MBCs is unclear. BILL-cadherin/cadherin-17 (CDH17) is the only member of the cadherin superfamily that is expressed on mouse B lymphocytes in a spatiotemporally regulated manner. Here, we show that half of all MBCs regain expression of CDH17 during the later stage of development. The maintenance of high affinity antigen-specific serum antibodies was impaired in CDH17(-/-)mice and the number of antigen-specific MBCs was reduced as compared to wildtype mice (WT). Also, specific responses to secondary antigens were ablated in CDH17(-/-)mice, whereas primary antibody responses were the same as those in WT mice. Cell cycle analysis revealed a decline in the proliferation of CDH17-MBCs as compared to CDH17(+) MBCs. In addition, we identified a subpopulation of splenic stromal cells, MAdCAM-1(+) blood endothelial cells (BEC), which was CDH17(+). Taken together, these results suggest that CDH17 plays a role in the long-term survival of MBCs, presumably via an "MBC niche" comprising, at least in part, BEC in the spleen.

リンク情報
DOI
https://doi.org/10.1371/journal.pone.0117566
PubMed
https://www.ncbi.nlm.nih.gov/pubmed/25612318
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000348562900036&DestApp=WOS_CPL
ID情報
  • DOI : 10.1371/journal.pone.0117566
  • ISSN : 1932-6203
  • PubMed ID : 25612318
  • Web of Science ID : WOS:000348562900036

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