Mihoko Ui

Profile Information

Affiliation: Assistant Professor, Graduate School of Medicine, Tohoku University

Degree: Ph.D(Mar, 2009, The University of Tokyo)

J-GLOBAL ID: 201001081043882669
researchmap Member ID: 6000022558

Papers

Amphiphilic structured PEG derivatives suppressing protein thermal aggregation at extremely low molecular ratio

Adam Wawro, Takahiro Muraoka, Wijak Yospanya, Mayu Kawame, Yudai Nakagawa, Mihoko Ui, Pawel Antonik, Peter Crowley, Kouhei Tsumoto, Kazushi Kinbara

Feb 9, 2023
Protein encapsulation in the hollow space of hemocyanin crystals containing a covalently conjugated ligand.

Tsubasa Hashimoto, Yuxin Ye, Mihoko Ui, Tomohisa Ogawa, Takashi Matsui, Yoshikazu Tanaka

Biochemical and biophysical research communications, 514(1) 31-36, Jun 18, 2019
Development of an Engineered Photoactive Yellow Protein as a Cross-_Linking Junction for Construction of Photoresponsive Protein-_Polymer Conjugates

Ui, Mihoko, Miyauchi, Yusuke, Inoue, Masataka, Murakami, Makoto, Araki, Yasuyuki, Wada, Takehiko, Kinbara, Kazushi

ChemPhotoChem, 3(6) 356-360, Jun, 2019 Peer-reviewed
Protein stabilization by an amphiphilic short monodisperse oligo(ethylene glycol)

Nabanita Sadhukhan, Takahiro Muraoka, Mihoko Ui, Satoru Nagatoishi, Kouhei Tsumoto, Kazushi Kinbara

CHEMICAL COMMUNICATIONS, 51(40) 8457-8460, 2015 Peer-reviewed
Thermal-aggregation suppression of proteins by a structured PEG analogue: Importance of denaturation temperature for effective aggregation suppression

Takahiro Muraoka, Nabanita Sadhukhan, Mihoko Ui, Shunichi Kawasaki, Enrikko Flazemi, Kota Adachi, Kazushi Kinbara

BIOCHEMICAL ENGINEERING JOURNAL, 86 41-48, May, 2014 Peer-reviewed
Grafting synthetic transmembrane units to the engineered low-toxicity alpha-hemolysin to restore its hemolytic activity

Mihoko Ui, Kousuke Harima, Toshiaki Takei, Kouhei Tsumoto, Kazuhito V. Tabata, Hiroyuki Noji, Sumire Endo, Kimio Akiyama, Takahiro Muraoka, Kazushi Kinbara

MOLECULAR BIOSYSTEMS, 10(12) 3199-3206, 2014 Peer-reviewed
Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin.

Kyohei Yumura, Mihoko Ui, Hirofumi Doi, Takao Hamakubo, Tatsuhiko Kodama, Kouhei Tsumoto, Akira Sugiyama

Protein science : a publication of the Protein Society, 22(2) 213-21, Feb, 2013 Peer-reviewed
A Structured Monodisperse PEG for the Effective Suppression of Protein Aggregation

Takahiro Muraoka, Kota Adachi, Mihoko Ui, Shunichi Kawasaki, Nabanita Sadhukhan, Haruki Obara, Hidehito Tochio, Masahiro Shirakawa, Kazushi Kinbara

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52(9) 2430-2434, 2013 Peer-reviewed
Application of photoactive yellow protein as a photoresponsive module for controlling hemolytic activity of staphylococcal alpha-hemolysin

Mihoko Ui, Yoshikazu Tanaka, Yasuyuki Araki, Takehiko Wada, Toshiaki Takei, Kouhei Tsumoto, Sumire Endo, Kazushi Kinbara

CHEMICAL COMMUNICATIONS, 48(39) 4737-4739, 2012 Peer-reviewed
Amplification of Light-induced Molecular-Shape Change by Supramolecular Machines

Mihoko Ui, Yoshikazu Tanaka, Kazushi Kinbara

JOURNAL OF PHOTOPOLYMER SCIENCE AND TECHNOLOGY, 25(5) 655-658, 2012
Structural and energetic hot-spots for the interaction between a ladder-like polycyclic ether and the anti-ciguatoxin antibody 10C9Fab

Mihoko Ui, Yoshikazu Tanaka, Takeshi Tsumuraya, Ikuo Fujii, Masayuki Inoue, Masahiro Hirama, Kouhei Tsumoto

MOLECULAR BIOSYSTEMS, 7(3) 793-798, 2011 Peer-reviewed
An approach to rational ligand-design based on a thermodynamic analysis

Mihoko Ui, Kouhei Tsumoto

Recent Patents on Biotechnology, 4(3) 183-188, 2010 Peer-reviewed
How protein recognizes ladder-like polycyclic ethers - Interactions between ciguatoxin (CTX3C) fragments and its specific antibody 10C9

Mihoko Ui, Yoshikazu Tanaka, Takeshi Tsumuraya, Ikuo Fujii, Masayuki Inoue, Masahiro Hirama, Kouhei Tsumoto

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(28) 19440-19447, Jul, 2008 Peer-reviewed
Critical contribution of aromatic rings to specific recognition of polyether rings - The case of ciguatoxin CTX3C-ABC and its specific antibody 1C49

Kouhei Tsumoto, Akiko Yokota, Yoshikazu Tanaka, Mihoko Ui, Takeshi Tsumuraya, Ikuo Fujii, Izumi Kumagai, Yoko Nagumo, Hiroki Oguri, Masayuki Inoue …

JOURNAL OF BIOLOGICAL CHEMISTRY, 283(18) 12259-12266, May, 2008 Peer-reviewed
1P-057 Molecular recognition mechanism of an anti-ciguatoxin antibody : mutational study and small-molecule binding screen(The 46th Annual Meeting of the Biophysical Society of Japan)

Ui Mihoko, Tanaka Yoshikazu, Tsumuraya Takeshi, Fujii Ikuo, Inoue Masayuki, Hirama Masahiro, Tsumoto Kouhei

Seibutsu Butsuri, 48 S29-S30, 2008
Pyrene-appended alpha-cyclodextrin as a fluorescent pH probe responding to a wide range

Suzuki, I, M Ui, A Yamauchi

ANALYTICAL SCIENCES, 22(5) 655-657, May, 2006 Peer-reviewed
Supramolecular probe for bicarbonate exhibiting anomalous pyrene fluorescence in aqueous media.

Iwao Suzuki, Mihoko Ui, Akiyo Yamauchi

Journal of the American Chemical Society, 127 4498-4499, 2006 Peer-reviewed

Misc.

光機能性材料開発に向けた光応答蛋白質‐親水性高分子複合体の構築

宇井美穂子, 宮内佑輔, 村上慎, 荒木保幸, 和田健彦, 金原数

日本化学会春季年会講演予稿集(CD-ROM), 97th ROMBUNNO.2PB‐156, Mar 3, 2017
Construction of photoresponsive protein‐polymer conjugates based on a junctional photoractive yellow protein

宇井美穂子, 宮内佑輔, 村上慎, 荒木保幸, 和田健彦, 金原数

化学系学協会東北大会プログラムおよび講演予稿集, 2016 117, Sep 10, 2016
改変型光受容蛋白質PYPの機能性材料への展開

宇井美穂子, 宮内佑輔, 村上慎, 荒木保幸, 和田健彦, 金原数

東北大学多元物質科学研究所研究発表会講演予稿集, 16th 54, 2016
光応答性タンパク質の特性を利用した機能性材料の創製

前島辰哉, 宇井美穂子, 荒木保幸, 和田健彦, 金原数

日本化学会講演予稿集, 95th(3) 951, Mar 11, 2015
改変型光応答性タンパク質モジュールを利用したソフトマテリアルの創製

宮内佑輔, 宇井美穂子, 村上慎, 荒木保幸, 和田健彦, 金原数

日本化学会講演予稿集, 94th(3) 973, Mar 12, 2014
光応答性phosphodiesteraseの構築と生体機能光制御への応用

宇井美穂子, 新井康広, 村上慎, 荒木保幸, 和田健彦, 高橋泰人, 金原数

日本化学会講演予稿集, 94th(3) 921, Mar 12, 2014
cAMPの可逆制御を目指した光応答性PDEの創製

新井康広, 宇井美穂子, 村上慎, 荒木保幸, 和田健彦, 高橋泰人, 金原数

日本化学会講演予稿集, 93rd(3) 1002, Mar 8, 2013
光応答性分子を用いた孔形成毒素alpha‐hemolysinの光制御系の構築

宇井美穂子, 播磨耕祐, 田中良和, 荒木保幸, 和田健彦, 武井俊朗, 津本浩平, 金原数

バイオ・高分子シンポジウム講演要旨集, 22nd 11-12, Jun 15, 2012
光受容蛋白質Phtoactive Yellow proteinを用いたStaphylococcal alpha‐Hemolysinの溶血活性制御

宇井美穂子, 田中良和, 荒木保幸, 和田健彦, 武井俊朗, 津本浩平, 金原数

高分子学会予稿集(CD-ROM), 61(1) ROMBUNNO.1H31, May 15, 2012
人工分子を用いたStaphylococcus aureus α‐hemolysinの溶血活性の制御

播磨耕祐, 宇井美穂子, 田中良和, 石井則行, 金原数

日本化学会講演予稿集, 92nd(3) 776, Mar 9, 2012
光応答性蛋白質Phtoactive Yellow protein融合Staphylococcal alpha‐Hemolysinの機能制御

宇井美穂子, 田中良和, 荒木保幸, 和田健彦, 武井俊朗, 津本浩平, 金原数

日本化学会講演予稿集, 92nd(3) 816, Mar 9, 2012
光応答性タンパク質PYP融合によるStaphylococcal α‐Hemolysinの光制御

宇井美穂子, 田中良和, 荒木保幸, 和田健彦, 武井俊朗, 津本浩平, 金原数

東北大学多元物質科学研究所研究発表会講演予稿集, 11th 23, 2011
Rational Fragment-design Method Based on a Thermodynamic Analysis

Kouhei Tsumoto, Mihoko Ui

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 129(11) 1311-1317, Nov, 2009
[Recognition mechanism for poly-cyclic ether toxin by anti-ciguatoxin antibody].

Ui M, Tsumoto K

Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme, 54(9) 1182-1189, Jul, 2009 Peer-reviewed
抗体による環状ポリエーテル系毒素シガトキシンの認識と識別

宇井美穂子, 津本浩平

蛋白質核酸酵素, 54 1182-1189, 2009
抗原抗体相互作用の熱力学的解析：特異性と親和性

津本浩平, 宇井美穂子

熱測定, 36 205-215, 2009
相互作用の熱力学情報に基づく低分子リガンド設計

津本浩平, 宇井美穂子

薬学雑誌, 2009
2P047 The structural and thermodynamic analysis of the interaction between ciguatoxin and its Antibody 10C9 Fab(Proteins-structure and structure-function relationship,Poster Presentations)

Ui Mihoko, Tanaka Yoshikazu, Tsumuraya Takeshi, Fujii Ikuo, Inoue Masayuki, Hirama Masahiro, Tsumoto Kouhei

Seibutsu Butsuri, 47 S124, 2007

Research Projects

Development of a photoresponsive module for protein photoregulation

Grants-in-Aid for Scientific Research, Grant-in-Aid for Scientific Research (C), Japan Society for the Promotion of Science, Apr, 2013 - Mar, 2016

Ui Mihoko
Construction of a photoregulating system for self-assembly proteins

Grants-in-Aid for Scientific Research, Grant-in-Aid for Young Scientists (B), Japan Society for the Promotion of Science, 2011 - 2012

UI Mihoko

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