MISC

2008年1月

Cannabidiol potentiates pharmacological effects of Delta(9)-tetrahydrocannabinol via CB1 receptor-dependent mechanism

BRAIN RESEARCH
  • Kazuhide Hayakawa
  • Kenichi Mishima
  • Mai Hazekawa
  • Kazunori Sano
  • Keiichi Irie
  • Kensuke Orito
  • Takashi Egawa
  • Yoshihisa Kitamura
  • Naoki Uchida
  • Ryoji Nishimura
  • Nobuaki Egashira
  • Katsunori Iwasaki
  • Michihiro Fujiwara
  • 全て表示

1188
開始ページ
157
終了ページ
164
記述言語
英語
掲載種別
DOI
10.1016/j.brainres.2007.09.090
出版者・発行元
ELSEVIER SCIENCE BV

Cannabidiol, a non-psycho active component of cannabis, has been reported to have interactions with Delta(9)-tetrahydrocannabinol (Delta(9)-THC). However, such interactions have not sufficiently been clear and may have important implications for understanding the pharmacological effects of marijuana. in the present study, we investigated whether cannabidiol modulates the pharmacological effects of Delta(9)-THC on locomotor activity, catalepsy-like immobilisation, rectal temperature and spatial memory in the eight-arm radial maze task in mice. in addition, we measured expression level of cannabinoid CB1 receptor at striatum, cortex, hippocampus and hypothalamus. Delta(9)-THC (1, 3, 6 and 10 mg/kg) induced hypoactivity, catalepsy-like immobilisation and hypothermia in a dose-dependent manner. In addition, Delta(9)-THC (1, 3 and 6 mg/kg) dose-dependently impaired spatial memory in eight-arm radial maze. On the other hand, cannabidiol (1, 3, 10, 25 and 50 mg/kg) did not affect locomotor activity, catalepsy-like immobilisation, rectal temperature and spatial memory on its own. However, higher dose of cannabidiol (10 or 50 mg/kg) exacerbated pharmacological effects of lower dose of Delta(9)-THC, such as hypoactivity, hypothermia and impairment of spatial memory. Moreover, cannabidiol (50 mg/kg) with Delta(9)-THC (1 mg/kg) enhanced the expression level of CB1 receptor expression in hippocampus and hypothalamus. Cannabidiol potentiated pharmacological effects of Delta(9)-THC via CB1 receptor-dependent mechanism. These findings may contribute in setting the basis for interaction of cannabinoids and to find a cannabinoid mechanism in central nervous system. (c) 2007 Elsevier B.V. All rights reserved.

リンク情報
DOI
https://doi.org/10.1016/j.brainres.2007.09.090
Web of Science
https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=JSTA_CEL&SrcApp=J_Gate_JST&DestLinkType=FullRecord&KeyUT=WOS:000252940700018&DestApp=WOS_CPL
ID情報
  • DOI : 10.1016/j.brainres.2007.09.090
  • ISSN : 0006-8993
  • eISSN : 1872-6240
  • Web of Science ID : WOS:000252940700018

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